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Cdc45 cell division cycle 45 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287961, updated on 5-Sep-2025
Official Symbol
Cdc45provided by RGD
Official Full Name
cell division cycle 45provided by RGD
Primary source
RGD:1590928
See related
Ensembl:ENSRNOG00000070046 AllianceGenome:RGD:1590928
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cdc45l
Summary
Predicted to be involved in several processes, including establishment of blood-retinal barrier; positive regulation of bicellular tight junction assembly; and regulation of gene expression. Predicted to be located in centrosome; ciliary basal body; and nucleoplasm. Predicted to be part of CMG complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Thymus (RPKM 75.7), Spleen (RPKM 37.8) and 8 other tissues See more
Orthologs
human mouse all
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See Cdc45 in Genome Data Viewer
Location:
11q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (95689702..95714980)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82185427..82210630)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86328785..86354099)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 22 open reading frame 39 Neighboring gene ubiquitin recognition factor in ER associated degradation 1 Neighboring gene claudin 5 Neighboring gene protein phosphatase 2 catalytic subunit alpha like 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Interactions of MCP1 with components of the replication machinery in mammalian cells. Bronze-da-Rocha E, et al. Int J Biol Sci, 2011 Feb 17. PMID 21383955, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Preferred Names
cell division control protein 45 homolog
Names
CDC45 cell division cycle 45-like
CDC45-related protein
cell division cycle 45 homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105866.2 → NP_001099336.1  cell division control protein 45 homolog

    See identical proteins and their annotated locations for NP_001099336.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161946
    UniProtKB/TrEMBL
    A0A8I6AEM5, A0A8I6AH40, A6JSE8, B1WBZ4
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 565
    CDC45; CDC45-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    95689702..95714980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270326.1 → XP_063126396.1  cell division control protein 45 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEM5, A0A8I6AH40, A6JSE8, B1WBZ4
    Related
    ENSRNOP00000092824.2, ENSRNOT00000106544.2

RNA

  1. XR_005490996.1 RNA Sequence

  2. XR_005490997.2 RNA Sequence

  3. XR_005490998.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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