U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F [ Rattus norvegicus (Norway rat) ]

Gene ID: 287931, updated on 10-Jul-2024

Summary

Official Symbol
Ppm1fprovided by RGD
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1Fprovided by RGD
Primary source
RGD:631363
See related
EnsemblRapid:ENSRNOG00000037909 AllianceGenome:RGD:631363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CaMKPase
Summary
Enables protein serine/threonine phosphatase activity. Involved in histone dephosphorylation and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol and perinuclear region of cytoplasm. Orthologous to human PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 318.0), Lung (RPKM 192.2) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ppm1f in Genome Data Viewer
Location:
11q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97568627..97598613, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (84064422..84094410, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88313709..88343726, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene yippee-like 1 Neighboring gene mitogen activated protein kinase 1 Neighboring gene DNA topoisomerase III beta Neighboring gene V-set pre-B cell surrogate light chain 1A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein phosphatase 1F
Names
CaM-kinase phosphatase
ca(2+)/calmodulin-dependent protein kinase phosphatase
calcium/calmodulin-dependent protein kinase phosphatase
partner of PIX 2
protein phosphatase 1F (PP2C domain containing)
NP_786931.1
XP_006248736.1
XP_038943992.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175755.2NP_786931.1  protein phosphatase 1F

    See identical proteins and their annotated locations for NP_786931.1

    Status: PROVISIONAL

    Source sequence(s)
    AB023634
    UniProtKB/Swiss-Prot
    Q9WVR7
    UniProtKB/TrEMBL
    A0A8I6A062, B2RYP5
    Conserved Domains (1) summary
    pfam00481
    Location:151402
    PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    97568627..97598613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088064.2XP_038943992.1  protein phosphatase 1F isoform X1

    UniProtKB/Swiss-Prot
    Q9WVR7
    UniProtKB/TrEMBL
    A0A8I6A062, B2RYP5
    Conserved Domains (1) summary
    pfam00481
    Location:151402
    PP2C; Protein phosphatase 2C
  2. XM_006248674.4XP_006248736.1  protein phosphatase 1F isoform X1

    See identical proteins and their annotated locations for XP_006248736.1

    UniProtKB/Swiss-Prot
    Q9WVR7
    UniProtKB/TrEMBL
    A0A8I6A062, B2RYP5
    Related
    ENSRNOP00000002530.3, ENSRNOT00000002530.7
    Conserved Domains (1) summary
    pfam00481
    Location:151402
    PP2C; Protein phosphatase 2C