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Vat1 vesicle amine transport 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287721, updated on 5-Jan-2022

Summary

Official Symbol
Vat1provided by RGD
Official Full Name
vesicle amine transport 1provided by RGD
Primary source
RGD:1308943
See related
Ensembl:ENSRNOG00000020684
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable oxidoreductase activity and zinc ion binding activity. Predicted to be involved in negative regulation of mitochondrial fusion. Located in mitochondrial outer membrane. Orthologous to human VAT1 (vesicle amine transport 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Lung (RPKM 291.6), Adrenal (RPKM 248.1) and 9 other tissues See more
Orthologs
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Genomic context

See Vat1 in Genome Data Viewer
Location:
10q31
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86389549..86397167, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89366898..89374516, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27 Neighboring gene interferon-induced protein 35 Neighboring gene Rho family GTPase 2 Neighboring gene BRCA1, DNA repair associated

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC124668

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
synaptic vesicle membrane protein VAT-1 homolog
Names
mitofusin-binding protein
vesicle amine transport protein 1 homolog (T californica)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033683.2NP_001028855.1  synaptic vesicle membrane protein VAT-1 homolog

    See identical proteins and their annotated locations for NP_001028855.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000220
    UniProtKB/Swiss-Prot
    Q3MIE4
    Related
    ENSRNOP00000028084.5, ENSRNOT00000028084.6
    Conserved Domains (1) summary
    cd08275
    Location:60398
    MDR3; Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    86389549..86397167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085620.1XP_038941548.1  synaptic vesicle membrane protein VAT-1 homolog isoform X1

    Conserved Domains (1) summary
    cd08275
    Location:39295
    MDR3; Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family
  2. XM_039085621.1XP_038941549.1  synaptic vesicle membrane protein VAT-1 homolog isoform X2

    Conserved Domains (1) summary
    cd08275
    Location:9265
    MDR3; Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family
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