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Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D [ Rattus norvegicus (Norway rat) ]

Gene ID: 287585, updated on 29-Jul-2018

Summary

Official Symbol
Ppm1dprovided by RGD
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1Dprovided by RGD
Primary source
RGD:1305460
See related
Ensembl:ENSRNOG00000003329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wip1
Expression
Biased expression in Testes (RPKM 154.0), Thymus (RPKM 69.2) and 9 other tissues See more
Orthologs

Genomic context

See Ppm1d in Genome Data Viewer
Location:
10q26
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72909550..72945884)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (72813803..72849854)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene similar to Chromodomain-helicase-DNA-binding protein 1 (CHD-1) Neighboring gene amyloid beta precursor protein binding protein 2 Neighboring gene BCAS3, microtubule associated cell migration factor Neighboring gene uncharacterized LOC102554092 Neighboring gene T-box 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from BioSystems

  • p53 pathway, organism-specific biosystem (from WikiPathways)
    p53 pathway, organism-specific biosystemp53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cyc...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA methylation IEA
Inferred from Electronic Annotation
more info
 
DNA methylation ISO
Inferred from Sequence Orthology
more info
 
G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
chromatin silencing IEA
Inferred from Electronic Annotation
more info
 
chromatin silencing ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
response to bacterium ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein phosphatase 1D
Names
p53-induced protein phosphatase 1
protein phosphatase 1D magnesium-dependent, delta isoform
NP_001099295.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105825.2NP_001099295.2  protein phosphatase 1D

    See identical proteins and their annotated locations for NP_001099295.2

    Status: VALIDATED

    Source sequence(s)
    AABR07030169, BC162058, FM140338
    UniProtKB/TrEMBL
    B1WCA0
    Related
    ENSRNOP00000004540.4, ENSRNOT00000004540.6
    Conserved Domains (1) summary
    pfam00481
    Location:84361
    PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    72909550..72945884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    69098036..69134596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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