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Rhbdl3 rhomboid like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287556, updated on 30-May-2026
Official Symbol
Rhbdl3provided by RGD
Official Full Name
rhomboid like 3provided by RGD
Primary source
RGD:1311901
See related
Ensembl:ENSRNOG00000005515 AllianceGenome:RGD:1311901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rhbdl4
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Orthologous to human RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Adrenal (RPKM 56.4), Thymus (RPKM 47.7) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Rhbdl3 in Genome Data Viewer
Location:
10q26
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65797145..65851949)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65299250..65354099)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67676999..67731670)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480832 Neighboring gene ring finger protein 135 Neighboring gene ras homolog family member T1 Neighboring gene similar to human chromosome 17 open reading frame 75 Neighboring gene microRNA 632 Neighboring gene zinc finger protein 207

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
rhomboid-related protein 3
Names
rhomboid protease 3
rhomboid, veinlet-like 3
rhomboid, veinlet-like 4
NP_001099289.1
XP_006247042.1
XP_006247044.1
XP_017452606.1
XP_038941472.1
XP_038941473.1
XP_063124756.1
XP_063124757.1
XP_063124758.1
XP_063124759.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105819.2 → NP_001099289.1  rhomboid-related protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001099289.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HHB1, D4AAW6
    Related
    ENSRNOP00000007312.5, ENSRNOT00000007312.6
    Conserved Domains (2) summary
    pfam01694
    Location:205 → 359
    Rhomboid; Rhomboid family
    pfam13499
    Location:36 → 100
    EF-hand_7; EF-hand domain pair

  2. NM_001439958.1 → NP_001426887.1  rhomboid-related protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AK12, D4AAW6

  3. NM_001439959.1 → NP_001426888.1  rhomboid-related protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  4. NM_001439960.1 → NP_001426889.1  rhomboid-related protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  5. NM_001439961.1 → NP_001426890.1  rhomboid-related protein 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  6. NM_001439962.1 → NP_001426891.1  rhomboid-related protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    65797145..65851949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246982.5 → XP_006247044.1  rhomboid-related protein 3 isoform X2

    Conserved Domains (3) summary
    pfam01694
    Location:205 → 313
    Rhomboid; Rhomboid family
    pfam13499
    Location:42 → 99
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:40 → 100
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_039085545.2 → XP_038941473.1  rhomboid-related protein 3 isoform X8

    Conserved Domains (2) summary
    pfam13499
    Location:36 → 100
    EF-hand_7; EF-hand domain pair
    cl21536
    Location:205 → 260
    Rhomboid; Rhomboid family

  3. XM_017597117.3 → XP_017452606.1  

  4. XM_063268689.1 → XP_063124759.1  rhomboid-related protein 3 isoform X9

  5. XM_063268686.1 → XP_063124756.1  

  6. XM_039085544.2 → XP_038941472.1  rhomboid-related protein 3 isoform X6

    Conserved Domains (2) summary
    pfam01694
    Location:205 → 294
    Rhomboid; Rhomboid family
    pfam13499
    Location:36 → 100
    EF-hand_7; EF-hand domain pair

  7. XM_063268688.1 → XP_063124758.1  

  8. XM_063268687.1 → XP_063124757.1  rhomboid-related protein 3 isoform X5

  9. XM_006246980.5 → XP_006247042.1  

    Related
    ENSRNOP00000094633.1, ENSRNOT00000111116.2
    Conserved Domains (2) summary
    pfam01694
    Location:197 → 351
    Rhomboid; Rhomboid family
    cl08302
    Location:36 → 92
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein Strain
Heading Accession and Version

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