Inpp5k inositol polyphosphate-5-phosphatase K [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inpp5kprovided by RGD
Official Full Name: inositol polyphosphate-5-phosphatase Kprovided by RGD
Primary source: RGD:1359130
See related: Ensembl:ENSRNOG00000056954 AllianceGenome:RGD:1359130
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Skip
Summary: Predicted to enable phosphatase activity and vasopressin receptor activity. Predicted to be involved in several processes, including negative regulation of metabolic process; negative regulation of signal transduction; and negative regulation of transport. Predicted to act upstream of or within several processes, including negative regulation of peptidyl-serine phosphorylation; phosphatidylinositol dephosphorylation; and response to insulin. Predicted to be located in several cellular components, including perinuclear region of cytoplasm; ruffle membrane; and trans-Golgi network. Predicted to be active in several cellular components, including endoplasmic reticulum; neuron projection; and ruffle. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Testes (RPKM 176.7), Adrenal (RPKM 138.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (60974183..60995047)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (60474262..60495813)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (63775639..63796879)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
Title: Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).

Submit: New GeneRIF Correction

General gene information

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Markers

AI511473 (e-PCR)
- UniSTS:226241

BE119095 (e-PCR)
- UniSTS:249086

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inositol bisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol bisphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol bisphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables inositol trisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol trisphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol trisphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol trisphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol trisphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables vasopressin receptor activity	IEA Inferred from Electronic Annotation more info
enables vasopressin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxygen-containing compound	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in host-mediated suppression of viral transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of D-glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of renal water transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of renal water transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urine volume	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in ruffle assembly	IEA Inferred from Electronic Annotation more info
involved_in ruffle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inositol polyphosphate 5-phosphatase K

Names: C62; putative phosphoinositide 5-phosphatase type II; putative phosphoinositide 5-phosphatase type II; C62; skeletal muscle and kidney enriched inositol phosphatase

NP_001013881.1

EC 3.1.3.36

XP_038941447.1

EC 3.1.3.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013859.1 → NP_001013881.1 inositol polyphosphate 5-phosphatase K

See identical proteins and their annotated locations for NP_001013881.1

Status: PROVISIONAL

Source sequence(s)

BC083572

UniProtKB/TrEMBL

A0A0G2K2Z2, Q5XIU8

Related

ENSRNOP00000072437.3, ENSRNOT00000090481.3

Conserved Domains (1) summary

cl00490
Location:17 → 317

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

60974183..60995047

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085519.2 → XP_038941447.1 inositol polyphosphate 5-phosphatase K isoform X1

UniProtKB/TrEMBL

A0A0G2K5K7

Related

ENSRNOP00000073462.2, ENSRNOT00000084496.3

Conserved Domains (2) summary

pfam17751
Location:271 → 371

SKICH; SKICH domain

cl00490
Location:2 → 260

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily