Format

Send to:

Choose Destination

Ctns cystinosin, lysosomal cystine transporter [ Rattus norvegicus (Norway rat) ]

Gene ID: 287478, updated on 21-Jul-2018

Summary

Official Symbol
Ctnsprovided by RGD
Official Full Name
cystinosin, lysosomal cystine transporterprovided by RGD
Primary source
RGD:1308466
See related
Ensembl:ENSRNOG00000028688
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Kidney (RPKM 60.2), Lung (RPKM 44.8) and 9 other tissues See more
Orthologs

Genomic context

See Ctns in Genome Data Viewer
Location:
10q24
Exon count:
15
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59749250..59772475, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (59488895..59503993, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene Tax1 binding protein 3 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene sedoheptulokinase Neighboring gene transient receptor potential cation channel, subfamily V, member 1 Neighboring gene transient receptor potential cation channel, subfamily V, member 3 Neighboring gene aspartoacylase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
L-cystine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-cystine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
L-cystine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
L-cystine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-cystine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
L-cystine transport ISO
Inferred from Sequence Orthology
more info
 
adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
adult walking behavior ISO
Inferred from Sequence Orthology
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
brain development ISO
Inferred from Sequence Orthology
more info
 
cognition ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
grooming behavior IEA
Inferred from Electronic Annotation
more info
 
grooming behavior ISO
Inferred from Sequence Orthology
more info
 
lens development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
long-term memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual learning IEA
Inferred from Electronic Annotation
more info
 
visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
NOT early endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
late endosome IEA
Inferred from Electronic Annotation
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cystinosin
Names
cystinosis, nephropathic

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191647.1NP_001178576.1  cystinosin precursor

    See identical proteins and their annotated locations for NP_001178576.1

    Status: PROVISIONAL

    Source sequence(s)
    AC126839
    UniProtKB/TrEMBL
    D3ZG79
    Related
    ENSRNOP00000031580.4, ENSRNOT00000030343.7
    Conserved Domains (2) summary
    TIGR00951
    Location:125357
    2A43; Lysosomal Cystine Transporter
    pfam04193
    Location:128185
    PQ-loop; PQ loop repeat

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    59749250..59772475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597111.1XP_017452600.1  cystinosin isoform X1

  2. XM_017597110.1XP_017452599.1  cystinosin isoform X1

  3. XM_017597112.1XP_017452601.1  cystinosin isoform X2

    UniProtKB/TrEMBL
    A0A0G2K358
    Related
    ENSRNOP00000072510.1, ENSRNOT00000083390.1

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    56924889..56939979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center