Pitpnm3 PITPNM family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pitpnm3provided by RGD
Official Full Name: PITPNM family member 3provided by RGD
Primary source: RGD:1308200
See related: Ensembl:ENSRNOG00000008323 AllianceGenome:RGD:1308200
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity; phospholipase activity; and receptor tyrosine kinase binding activity. Located in cell body and cell projection. Human ortholog(s) of this gene implicated in cone-rod dystrophy 5. Orthologous to human PITPNM3 (PITPNM family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 66.5), Lung (RPKM 59.2) and 8 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (57173230..57265186, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (56674697..56766552, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (58618679..58722679, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

Preferred Names: membrane-associated phosphatidylinositol transfer protein 3

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_039087319.2 → XP_038943247.1 membrane-associated phosphatidylinositol transfer protein 3 isoform X1

UniProtKB/TrEMBL

A6HGD7, M0RDK4

Related

ENSRNOP00000067705.3

Conserved Domains (2) summary

smart00775
Location:739 → 869

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:393 → 593

DDHD; DDHD domain
XM_063270035.1 → XP_063126105.1 membrane-associated phosphatidylinositol transfer protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I5ZTJ8
XM_039087320.2 → XP_038943248.1 membrane-associated phosphatidylinositol transfer protein 3 isoform X4

Conserved Domains (2) summary

smart00775
Location:317 → 447

LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins

pfam02862
Location:2 → 171

DDHD; DDHD domain
XM_063270036.1 → XP_063126106.1 membrane-associated phosphatidylinositol transfer protein 3 isoform X3