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Ctdnep1 CTD nuclear envelope phosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287447, updated on 5-Jan-2022

Summary

Official Symbol
Ctdnep1provided by RGD
Official Full Name
CTD nuclear envelope phosphatase 1provided by RGD
Primary source
RGD:1310172
See related
Ensembl:ENSRNOG00000017352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dullard
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including positive regulation of triglyceride biosynthetic process; protein dephosphorylation; and protein localization to nucleus. Predicted to act upstream of or within gamete generation; mesoderm development; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Muscle (RPKM 174.6), Spleen (RPKM 98.0) and 9 other tissues See more
Orthologs
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Genomic context

See Ctdnep1 in Genome Data Viewer
Location:
10q24
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54704367..54713781)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56590822..56600235)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene claudin 7 Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene uncharacterized LOC120095128 Neighboring gene GABA type A receptor-associated protein Neighboring gene PHD finger protein 23

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
acts_upstream_of_or_within gamete generation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear envelope organization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of Nem1-Spo7 phosphatase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Nem1-Spo7 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CTD nuclear envelope phosphatase 1
Names
serine/threonine-protein phosphatase dullard
NP_001093964.1
XP_006246705.2
XP_006246706.2
XP_017452582.2
XP_017452583.2
XP_017452584.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100494.1NP_001093964.1  CTD nuclear envelope phosphatase 1

    See identical proteins and their annotated locations for NP_001093964.1

    Status: VALIDATED

    Source sequence(s)
    BC107474, BU671232
    UniProtKB/Swiss-Prot
    Q3B7T6
    Related
    ENSRNOP00000023379.5, ENSRNOT00000023379.5
    Conserved Domains (1) summary
    TIGR02251
    Location:61229
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    54704367..54713781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597093.2XP_017452582.2  CTD nuclear envelope phosphatase 1 isoform X1

    Conserved Domains (1) summary
    TIGR02251
    Location:93263
    HIF-SF_euk; Dullard-like phosphatase domain
  2. XM_006246643.4XP_006246705.2  CTD nuclear envelope phosphatase 1 isoform X3

    Conserved Domains (1) summary
    TIGR02251
    Location:93265
    HIF-SF_euk; Dullard-like phosphatase domain
  3. XM_017597094.2XP_017452583.2  CTD nuclear envelope phosphatase 1 isoform X2

    Conserved Domains (1) summary
    TIGR02251
    Location:93259
    HIF-SF_euk; Dullard-like phosphatase domain
  4. XM_017597095.2XP_017452584.2  CTD nuclear envelope phosphatase 1 isoform X5

    Conserved Domains (1) summary
    TIGR02251
    Location:61231
    HIF-SF_euk; Dullard-like phosphatase domain
  5. XM_006246644.4XP_006246706.2  CTD nuclear envelope phosphatase 1 isoform X4

    Related
    ENSRNOP00000096868.1, ENSRNOT00000114193.1
    Conserved Domains (1) summary
    TIGR02251
    Location:93261
    HIF-SF_euk; Dullard-like phosphatase domain
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