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Cops3 COP9 signalosome subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287367, updated on 12-Jan-2022

Summary

Official Symbol
Cops3provided by RGD
Official Full Name
COP9 signalosome subunit 3provided by RGD
Primary source
RGD:1303002
See related
Ensembl:ENSRNOG00000053943
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein deneddylation and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS3 (COP9 signalosome subunit 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Muscle (RPKM 480.7), Heart (RPKM 340.0) and 9 other tissues See more
Orthologs
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Genomic context

See Cops3 in Genome Data Viewer
Location:
10q22
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (44618115..44652807, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46182680..46206083, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene folliculin Neighboring gene dCTP pyrophosphatase 1-like Neighboring gene U1 spliceosomal RNA Neighboring gene 5',3'-nucleotidase, mitochondrial Neighboring gene mediator complex subunit 9

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC94156

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
COP9 signalosome complex subunit 3
Names
COP9 (constitutive photomorphogenic) homolog, subunit 3
SGN3
signalosome subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004200.1NP_001004200.1  COP9 signalosome complex subunit 3

    See identical proteins and their annotated locations for NP_001004200.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079143
    UniProtKB/Swiss-Prot
    Q68FW9
    Related
    ENSRNOP00000069208.1, ENSRNOT00000091471.2
    Conserved Domains (1) summary
    pfam01399
    Location:259362
    PCI; PCI domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    44618115..44652807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085398.1XP_038941326.1  COP9 signalosome complex subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam01399
    Location:253356
    PCI; PCI domain
  2. XM_039085399.1XP_038941327.1  COP9 signalosome complex subunit 3 isoform X2

    Conserved Domains (1) summary
    pfam01399
    Location:239342
    PCI; PCI domain
  3. XM_017597079.2XP_017452568.1  COP9 signalosome complex subunit 3 isoform X3

    Conserved Domains (1) summary
    pfam01399
    Location:129232
    PCI; PCI domain

RNA

  1. XR_005489724.1 RNA Sequence

  2. XR_005489723.1 RNA Sequence

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