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GPS1 G protein pathway suppressor 1 [ Homo sapiens (human) ]

Gene ID: 2873, updated on 24-Nov-2020

Summary

Official Symbol
GPS1provided by HGNC
Official Full Name
G protein pathway suppressor 1provided by HGNC
Primary source
HGNC:HGNC:4549
See related
Ensembl:ENSG00000169727 MIM:601934
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSN1; SGN1; COPS1
Summary
This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in kidney (RPKM 28.1), testis (RPKM 27.1) and 25 other tissues See more
Orthologs

Genomic context

See GPS1 in Genome Data Viewer
Location:
17q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (82051465..82058064)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80009746..80015346)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene DCXR divergent transcript Neighboring gene dicarbonyl and L-xylulose reductase Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1 like Neighboring gene fatty acid synthase Neighboring gene small nucleolar RNA, C/D box 134 Neighboring gene coiled-coil domain containing 57 Neighboring gene Sharpr-MPRA regulatory region 14342

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with G protein pathway suppressor 1 (GPS1; COPS1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71287

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
JNK cascade TAS
Traceable Author Statement
more info
PubMed 
inactivation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair, DNA damage recognition TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein deneddylation IDA
Inferred from Direct Assay
more info
PubMed 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
COP9 signalosome complex subunit 1
Names
JAB1-containing signalosome subunit 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321089.2NP_001308018.1  COP9 signalosome complex subunit 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC135056, AK026610, BP306851
    Conserved Domains (2) summary
    pfam01399
    Location:392496
    PCI; PCI domain
    pfam10602
    Location:195377
    RPN7; 26S proteasome subunit RPN7
  2. NM_001321090.2NP_001308019.1  COP9 signalosome complex subunit 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC135056, AK026610, BP306851
    Conserved Domains (2) summary
    pfam01399
    Location:388492
    PCI; PCI domain
    pfam10602
    Location:191373
    RPN7; 26S proteasome subunit RPN7
  3. NM_001321091.2NP_001308020.1  COP9 signalosome complex subunit 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC135056, AK026610, BP306851
    Conserved Domains (2) summary
    pfam01399
    Location:387491
    PCI; PCI domain
    pfam10602
    Location:191372
    RPN7; 26S proteasome subunit RPN7
  4. NM_001321092.2NP_001308021.1  COP9 signalosome complex subunit 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC135056, AK026610, AK222508, BP306851
    Consensus CDS
    CCDS82226.1
    UniProtKB/Swiss-Prot
    Q13098
    Related
    ENSP00000462265.1, ENST00000578552.5
    Conserved Domains (2) summary
    pfam01399
    Location:320424
    PCI; PCI domain
    pfam10602
    Location:123305
    RPN7; 26S proteasome subunit RPN7
  5. NM_001321093.2NP_001308022.1  COP9 signalosome complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC135056, AK026610, BP306851
    Consensus CDS
    CCDS82228.1
    UniProtKB/TrEMBL
    C9JFE4
    Related
    ENSP00000313569.4, ENST00000320548.8
    Conserved Domains (2) summary
    pfam01399
    Location:304408
    PCI; PCI domain
    pfam10602
    Location:107289
    RPN7; 26S proteasome subunit RPN7
  6. NM_001330539.2NP_001317468.1  COP9 signalosome complex subunit 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC135056, BQ001772
    Consensus CDS
    CCDS82227.1
    UniProtKB/TrEMBL
    A0A096LP07
    Related
    ENSP00000485330.1, ENST00000623691.3
    Conserved Domains (2) summary
    pfam01399
    Location:319423
    PCI; PCI domain
    pfam10602
    Location:123304
    RPN7; 26S proteasome subunit RPN7
  7. NM_001330541.2NP_001317470.1  COP9 signalosome complex subunit 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC135056, BQ001772
    Consensus CDS
    CCDS82225.1
    UniProtKB/TrEMBL
    A0A096LPJ3
    Related
    ENSP00000485641.1, ENST00000624957.3
    Conserved Domains (2) summary
    pfam01399
    Location:323427
    PCI; PCI domain
    pfam10602
    Location:127308
    RPN7; 26S proteasome subunit RPN7
  8. NM_004127.6NP_004118.3  COP9 signalosome complex subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_004118.3

    Status: REVIEWED

    Source sequence(s)
    AC135056, BC000155, BC064503, BP306851
    Consensus CDS
    CCDS32774.1
    UniProtKB/Swiss-Prot
    Q13098
    Related
    ENSP00000302873.6, ENST00000306823.10
    Conserved Domains (2) summary
    pfam01399
    Location:324428
    PCI; PCI domain
    pfam10602
    Location:127309
    RPN7; 26S proteasome subunit RPN7
  9. NM_212492.3NP_997657.1  COP9 signalosome complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_997657.1

    Status: REVIEWED

    Source sequence(s)
    AC135056, BC064503, BP306851
    Consensus CDS
    CCDS11800.1
    UniProtKB/Swiss-Prot
    Q13098
    Related
    ENSP00000376167.2, ENST00000392358.6
    Conserved Domains (2) summary
    pfam01399
    Location:360464
    PCI; PCI domain
    pfam10602
    Location:163345
    RPN7; 26S proteasome subunit RPN7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    82051465..82058064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450726.1XP_024306494.1  COP9 signalosome complex subunit 1 isoform X16

    Conserved Domains (2) summary
    pfam01399
    Location:304434
    PCI; PCI domain
    pfam10602
    Location:107289
    RPN7; 26S proteasome subunit RPN7
  2. XM_024450723.1XP_024306491.1  COP9 signalosome complex subunit 1 isoform X15

    Conserved Domains (2) summary
    pfam01399
    Location:308438
    PCI; PCI domain
    pfam10602
    Location:111293
    RPN7; 26S proteasome subunit RPN7
  3. XM_024450724.1XP_024306492.1  COP9 signalosome complex subunit 1 isoform X2

    Conserved Domains (2) summary
    pfam01399
    Location:307437
    PCI; PCI domain
    pfam10602
    Location:111292
    RPN7; 26S proteasome subunit RPN7
  4. XM_024450728.1XP_024306496.1  COP9 signalosome complex subunit 1 isoform X23

    Conserved Domains (2) summary
    pfam01399
    Location:303407
    PCI; PCI domain
    pfam10602
    Location:107288
    RPN7; 26S proteasome subunit RPN7
  5. XM_024450718.1XP_024306486.1  COP9 signalosome complex subunit 1 isoform X10

    Conserved Domains (2) summary
    pfam01399
    Location:360490
    PCI; PCI domain
    pfam10602
    Location:163345
    RPN7; 26S proteasome subunit RPN7
  6. XM_024450725.1XP_024306493.1  COP9 signalosome complex subunit 1 isoform X16

    Conserved Domains (2) summary
    pfam01399
    Location:304434
    PCI; PCI domain
    pfam10602
    Location:107289
    RPN7; 26S proteasome subunit RPN7
  7. XM_024450715.1XP_024306483.1  COP9 signalosome complex subunit 1 isoform X3

    Conserved Domains (2) summary
    pfam01399
    Location:392522
    PCI; PCI domain
    pfam10602
    Location:195377
    RPN7; 26S proteasome subunit RPN7
  8. XM_005256350.1XP_005256407.1  COP9 signalosome complex subunit 1 isoform X6

    Conserved Domains (2) summary
    pfam01399
    Location:392496
    PCI; PCI domain
    pfam10602
    Location:195377
    RPN7; 26S proteasome subunit RPN7
  9. XM_024450713.1XP_024306481.1  COP9 signalosome complex subunit 1 isoform X1

    Conserved Domains (2) summary
    pfam01399
    Location:450554
    PCI; PCI domain
    pfam10602
    Location:191435
    RPN7; 26S proteasome subunit RPN7
  10. XM_024450716.1XP_024306484.1  COP9 signalosome complex subunit 1 isoform X4

    Conserved Domains (2) summary
    pfam01399
    Location:388518
    PCI; PCI domain
    pfam10602
    Location:191373
    RPN7; 26S proteasome subunit RPN7
  11. XM_024450717.1XP_024306485.1  COP9 signalosome complex subunit 1 isoform X8

    Conserved Domains (2) summary
    pfam01399
    Location:388518
    PCI; PCI domain
    pfam10602
    Location:191373
    RPN7; 26S proteasome subunit RPN7
  12. XM_005256353.1XP_005256410.1  COP9 signalosome complex subunit 1 isoform X7

    Conserved Domains (2) summary
    pfam01399
    Location:388492
    PCI; PCI domain
    pfam10602
    Location:191373
    RPN7; 26S proteasome subunit RPN7
  13. XM_017024525.1XP_016880014.1  COP9 signalosome complex subunit 1 isoform X9

  14. XM_024450719.1XP_024306487.1  COP9 signalosome complex subunit 1 isoform X12

    Conserved Domains (2) summary
    pfam01399
    Location:324454
    PCI; PCI domain
    pfam10602
    Location:127309
    RPN7; 26S proteasome subunit RPN7
  15. XM_005256359.2XP_005256416.1  COP9 signalosome complex subunit 1 isoform X17

    Conserved Domains (2) summary
    pfam01399
    Location:324428
    PCI; PCI domain
    pfam10602
    Location:127309
    RPN7; 26S proteasome subunit RPN7
  16. XM_024450720.1XP_024306488.1  COP9 signalosome complex subunit 1 isoform X13

    Conserved Domains (2) summary
    pfam01399
    Location:320450
    PCI; PCI domain
    pfam10602
    Location:123305
    RPN7; 26S proteasome subunit RPN7
  17. XM_024450727.1XP_024306495.1  COP9 signalosome complex subunit 1 isoform X19

    Conserved Domains (2) summary
    pfam01399
    Location:320450
    PCI; PCI domain
    pfam10602
    Location:123305
    RPN7; 26S proteasome subunit RPN7
  18. XM_005256360.4XP_005256417.1  COP9 signalosome complex subunit 1 isoform X18

    Conserved Domains (2) summary
    pfam01399
    Location:320424
    PCI; PCI domain
    pfam10602
    Location:123305
    RPN7; 26S proteasome subunit RPN7
  19. XM_024450721.1XP_024306489.1  COP9 signalosome complex subunit 1 isoform X14

    Conserved Domains (2) summary
    pfam01399
    Location:319449
    PCI; PCI domain
    pfam10602
    Location:123304
    RPN7; 26S proteasome subunit RPN7
  20. XM_017024527.2XP_016880016.1  COP9 signalosome complex subunit 1 isoform X20

  21. XM_017024535.2XP_016880024.1  COP9 signalosome complex subunit 1 isoform X23

    Conserved Domains (2) summary
    pfam01399
    Location:303407
    PCI; PCI domain
    pfam10602
    Location:107288
    RPN7; 26S proteasome subunit RPN7
  22. XM_017024531.2XP_016880020.1  COP9 signalosome complex subunit 1 isoform X21

  23. XM_024450722.1XP_024306490.1  COP9 signalosome complex subunit 1 isoform X15

    Conserved Domains (2) summary
    pfam01399
    Location:308438
    PCI; PCI domain
    pfam10602
    Location:111293
    RPN7; 26S proteasome subunit RPN7
  24. XM_017024534.1XP_016880023.1  COP9 signalosome complex subunit 1 isoform X22

    UniProtKB/Swiss-Prot
    Q13098
    Conserved Domains (2) summary
    pfam01399
    Location:308412
    PCI; PCI domain
    pfam10602
    Location:111293
    RPN7; 26S proteasome subunit RPN7
  25. XM_024450714.1XP_024306482.1  COP9 signalosome complex subunit 1 isoform X2

    Conserved Domains (2) summary
    pfam01399
    Location:307437
    PCI; PCI domain
    pfam10602
    Location:111292
    RPN7; 26S proteasome subunit RPN7
  26. XM_017024524.2XP_016880013.1  COP9 signalosome complex subunit 1 isoform X5

  27. XM_017024526.2XP_016880015.1  COP9 signalosome complex subunit 1 isoform X11

    Related
    ENSP00000485035.1, ENST00000623761.3
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