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Clec16a C-type lectin domain containing 16A [ Rattus norvegicus (Norway rat) ]

Gene ID: 287044, updated on 24-Jul-2025
Official Symbol
Clec16aprovided by RGD
Official Full Name
C-type lectin domain containing 16Aprovided by RGD
Primary source
RGD:1305773
See related
Ensembl:ENSRNOG00000057378 AllianceGenome:RGD:1305773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305773
Summary
Predicted to be involved in several processes, including positive regulation of TORC1 signaling; protein destabilization; and regulation of catabolic process. Predicted to act upstream of or within negative regulation of mitophagy; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of autophagosome maturation. Predicted to be located in cytosol and endolysosome membrane. Predicted to be active in Golgi apparatus. Predicted to colocalize with late endosome. Human ortholog(s) of this gene implicated in Addison's disease; multiple sclerosis; rheumatoid arthritis; and type 1 diabetes mellitus. Orthologous to human CLEC16A (C-type lectin domain containing 16A). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Kidney (RPKM 103.9), Heart (RPKM 93.2) and 9 other tissues See more
Orthologs
human mouse all
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See Clec16a in Genome Data Viewer
Location:
10q11
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (5434725..5631246, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4927799..5123749, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (5002196..5196914, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095020 Neighboring gene uncharacterized LOC134480746 Neighboring gene suppressor of cytokine signaling 1 Neighboring gene transition protein 2 Neighboring gene uncharacterized LOC120095021 Neighboring gene uncharacterized LOC134480747 Neighboring gene Dexi homolog Neighboring gene class II, major histocompatibility complex, transactivator

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia. Zoledziewska M, et al. Genes Immun, 2009 Jan. PMID 18946483
  2. Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex. Zuvich RL, et al. Hum Mol Genet, 2011 Sep 1. PMID 21653641, Free PMC Article
  3. Chromosomal region 16p13: further evidence of increased predisposition to immune diseases. Martínez A, et al. Ann Rheum Dis, 2010 Jan. PMID 19221398
  4. The diabetes susceptibility gene Clec16a regulates mitophagy. Soleimanpour SA, et al. Cell, 2014 Jun 19. PMID 24949970, Free PMC Article
  5. Human CLEC16A regulates autophagy through modulating mTOR activity. Tam RC, et al. Exp Cell Res, 2017 Mar 15. PMID 28223137

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in mitophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagosome maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vacuolar transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endolysosome membrane ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
protein CLEC16A
Names
C-type lectin domain family 16, member A

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398551.1 → NP_001385480.1  protein CLEC16A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZW56
    Related
    ENSRNOP00000083500.2, ENSRNOT00000105739.2
    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; Uncharacterized conserved protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    5434725..5631246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268510.1 → XP_063124580.1  protein CLEC16A isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZW56
    Related
    ENSRNOP00000098659.1, ENSRNOT00000147630.1

  2. XM_063268511.1 → XP_063124581.1  protein CLEC16A isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZW56
    Related
    ENSRNOP00000105131.1, ENSRNOT00000147778.1

  3. XM_008767506.4 → XP_008765728.1  protein CLEC16A isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZW56, A0A8I5ZW58
    Conserved Domains (1) summary
    pfam09758
    Location:51 → 198
    FPL; uncharacterized conserved protein

  4. XM_039087046.2 → XP_038942974.1  protein CLEC16A isoform X13

    UniProtKB/TrEMBL
    A6K4J0

  5. XM_063268512.1 → XP_063124582.1  protein CLEC16A isoform X4

    UniProtKB/TrEMBL
    A0A8I6ASQ2
    Related
    ENSRNOP00000075216.3, ENSRNOT00000083982.3

  6. XM_063268515.1 → XP_063124585.1  protein CLEC16A isoform X6

    UniProtKB/TrEMBL
    A0A8I6ASQ2, A0A8I6AX58
    Related
    ENSRNOP00000093525.1, ENSRNOT00000101220.2

  7. XM_063268514.1 → XP_063124584.1  protein CLEC16A isoform X5

    UniProtKB/TrEMBL
    A0A8I6ASQ2

  8. XM_063268517.1 → XP_063124587.1  protein CLEC16A isoform X8

    UniProtKB/TrEMBL
    A0A8I6ASQ2

  9. XM_063268516.1 → XP_063124586.1  protein CLEC16A isoform X7

    UniProtKB/TrEMBL
    A0A8I6ASQ2
    Related
    ENSRNOP00000097322.1, ENSRNOT00000120301.2

  10. XM_063268518.1 → XP_063124588.1  protein CLEC16A isoform X9

    UniProtKB/TrEMBL
    A0A8I6ASQ2

  11. XM_063268521.1 → XP_063124591.1  protein CLEC16A isoform X12

  12. XM_063268520.1 → XP_063124590.1  protein CLEC16A isoform X11

  13. XM_063268519.1 → XP_063124589.1  protein CLEC16A isoform X10

    UniProtKB/TrEMBL
    A0A8I6ASQ2
Nucleotide Protein Strain
Heading Accession and Version

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