U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slco6c1 solute carrier organic anion transporter family, member 6c1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287006, updated on 3-Jun-2026
Symbol
Slco6c1provided by RGD
Full Name
solute carrier organic anion transporter family, member 6c1provided by RGD
Primary source
RGD:708431
See related
Ensembl:ENSRNOG00000013792 AllianceGenome:RGD:708431
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GST-2
Summary
Enables organic anion transmembrane transporter activity. Involved in organic anion transport. Predicted to be part of CatSper complex. Predicted to be active in basolateral plasma membrane. Orthologous to human SLCO6A1 (solute carrier organic anion transporter family member 6A1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Restricted expression toward (RPKM 122.7) See more
Try the new Gene page
Try the new Transcripts and proteins table
See Slco6c1 in Genome Data Viewer
Location:
9q36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (104947509..105028079, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (97500028..97580776, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (104622119..104700657, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 40 Neighboring gene solute carrier organic anion transporter family member 6c1 like, pseudogene 1 Neighboring gene uncharacterized LOC134480421 Neighboring gene solute carrier organic anion transporter family, member 6d1 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 6

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Interactions of cationic drugs and cardiac glycosides at the hepatic uptake level: studies in the rat in vivo, isolated perfused rat liver, isolated rat hepatocytes and oocytes expressing oatp2. Meijer DK, et al. Arch Pharm Res, 2002 Aug. PMID 12214846
  2. Identification and characterization of novel rat and human gonad-specific organic anion transporters. Suzuki T, et al. Mol Endocrinol, 2003 Jul. PMID 12677006
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a novel organic anion transporter expressed at high levels in the testis
    Title: Identification and characterization of novel rat and human gonad-specific organic anion transporters.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables secondary active transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CatSper complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
solute carrier organic anion transporter family, member 6c1
Names
gonad-specific transporter 2
solute carrier organic anion transporter family member 6A1-like
testis-specific transporter TST-2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173338.1 → NP_775460.1  solute carrier organic anion transporter family, member 6c1

    See identical proteins and their annotated locations for NP_775460.1

    Status: PROVISIONAL

    Source sequence(s)
    AF326113
    UniProtKB/TrEMBL
    A6JR55, G3V7R7, Q8K4K9
    Related
    ENSRNOP00000068805.1, ENSRNOT00000077480.3
    Conserved Domains (3) summary
    cd06174
    Location:90 → 457
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:481 → 534
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:88 → 648
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    104947509..105028079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266805.1 → XP_063122875.1  solute carrier organic anion transporter family, member 6c1 isoform X7

  2. XM_063266804.1 → XP_063122874.1  solute carrier organic anion transporter family, member 6c1 isoform X5

  3. XM_063266808.1 → XP_063122878.1  solute carrier organic anion transporter family, member 6c1 isoform X12

  4. XM_039083104.2 → XP_038939032.1  solute carrier organic anion transporter family, member 6c1 isoform X6

    Conserved Domains (1) summary
    cl28910
    Location:101 → 437
    MFS; Major Facilitator Superfamily

  5. XM_063266802.1 → XP_063122872.1  solute carrier organic anion transporter family, member 6c1 isoform X3

    UniProtKB/TrEMBL
    A6JR55, G3V7R7

  6. XM_063266800.1 → XP_063122870.1  solute carrier organic anion transporter family, member 6c1 isoform X1

    UniProtKB/TrEMBL
    A6JR55, G3V7R7

  7. XM_039083103.2 → XP_038939031.1  solute carrier organic anion transporter family, member 6c1 isoform X2

    UniProtKB/TrEMBL
    A6JR55, G3V7R7
    Conserved Domains (1) summary
    cl28910
    Location:86 → 503
    MFS; Major Facilitator Superfamily

  8. XM_063266806.1 → XP_063122876.1  solute carrier organic anion transporter family, member 6c1 isoform X8

  9. XM_063266803.1 → XP_063122873.1  solute carrier organic anion transporter family, member 6c1 isoform X4

  10. XM_039083106.2 → XP_038939034.1  solute carrier organic anion transporter family, member 6c1 isoform X10

    Conserved Domains (1) summary
    cl28910
    Location:86 → 408
    MFS; Major Facilitator Superfamily

  11. XM_039083105.2 → XP_038939033.2  solute carrier organic anion transporter family, member 6c1 isoform X9

  12. XM_063266807.1 → XP_063122877.1  solute carrier organic anion transporter family, member 6c1 isoform X11

RNA

  1. XR_005488857.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools