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GRK6 G protein-coupled receptor kinase 6 [ Homo sapiens (human) ]

Gene ID: 2870, updated on 7-Dec-2018

Summary

Official Symbol
GRK6provided by HGNC
Official Full Name
G protein-coupled receptor kinase 6provided by HGNC
Primary source
HGNC:HGNC:4545
See related
Ensembl:ENSG00000198055 MIM:600869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPRK6
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 27.2), lymph node (RPKM 19.5) and 23 other tissues See more
Orthologs

Genomic context

See GRK6 in Genome Data Viewer
Location:
5q35.3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (177426496..177442849)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176853687..176869850)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3 Neighboring gene coagulation factor XII Neighboring gene PRR7 antisense RNA 1 Neighboring gene proline rich 7, synaptic Neighboring gene drebrin 1 Neighboring gene PDZ and LIM domain 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog
New loci associated with kidney function and chronic kidney disease.
NHGRI GWA Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
NHGRI GWA Catalog

Pathways from BioSystems

  • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CXCR4-mediated signaling events, organism-specific biosystem
    CXCR4-mediated signaling events
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Corticotropin-releasing hormone signaling pathway, organism-specific biosystem (from WikiPathways)
    Corticotropin-releasing hormone signaling pathway, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Follicle Stimulating Hormone (FSH) signaling pathway, organism-specific biosystem (from WikiPathways)
    Follicle Stimulating Hormone (FSH) signaling pathway, organism-specific biosystemThe Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH)...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
beta-adrenergic receptor kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
beta-adrenergic receptor kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
beta-adrenergic receptor kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G protein-coupled receptor kinase 6
NP_001004105.1
NP_001004106.1
NP_002073.2
XP_006714921.1
XP_006714922.1
XP_011532839.1
XP_011532840.1
XP_024301800.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031981.1 RefSeqGene

    Range
    5001..21164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004105.2NP_001004105.1  G protein-coupled receptor kinase 6 isoform C

    See identical proteins and their annotated locations for NP_001004105.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 2, resulting in a shorter isoform (C) with a distinct C-terminus compared to isoform B.
    Source sequence(s)
    AF040752, BC009277, BI258860
    Consensus CDS
    CCDS43406.1
    UniProtKB/Swiss-Prot
    P43250
    Related
    ENSP00000348230.5, ENST00000355958.9
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_001004106.3NP_001004106.1  G protein-coupled receptor kinase 6 isoform A

    See identical proteins and their annotated locations for NP_001004106.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate acceptor splice site in the last exon, compared to variant 2, resulting in a shorter isoform (A) compared to isoform B.
    Source sequence(s)
    AC145098, BC009277, BI258860
    Consensus CDS
    CCDS34303.1
    UniProtKB/Swiss-Prot
    P43250
    Related
    ENSP00000347655.5, ENST00000355472.9
    Conserved Domains (2) summary
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. NM_001364164.1NP_001351093.1  G protein-coupled receptor kinase 6 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC145098
    Conserved Domains (1) summary
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  4. NM_002082.3NP_002073.2  G protein-coupled receptor kinase 6 isoform B

    See identical proteins and their annotated locations for NP_002073.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (B).
    Source sequence(s)
    AC145098, AF040751, BC009277, BI258860
    UniProtKB/Swiss-Prot
    P43250
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    177426496..177442849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714859.2XP_006714922.1  G protein-coupled receptor kinase 6 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:154416
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:153437
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:3147
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. XM_011534537.2XP_011532839.1  G protein-coupled receptor kinase 6 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:147409
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:146430
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:47140
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. XM_024446032.1XP_024301800.1  G protein-coupled receptor kinase 6 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006714858.3XP_006714921.1  G protein-coupled receptor kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006714921.1

    UniProtKB/TrEMBL
    B3KPS5
    Conserved Domains (3) summary
    smart00220
    Location:156418
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:155439
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:20149
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  5. XM_011534538.1XP_011532840.1  G protein-coupled receptor kinase 6 isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:1183
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1204
    PKc_like; Protein Kinases, catalytic domain
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