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ANK2 ankyrin 2 [ Homo sapiens (human) ]

Gene ID: 287, updated on 11-May-2021

Summary

Official Symbol
ANK2provided by HGNC
Official Full Name
ankyrin 2provided by HGNC
Primary source
HGNC:HGNC:493
See related
Ensembl:ENSG00000145362 MIM:106410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LQT4; ANK-2; FAP87; CFAP87; brank-2
Summary
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
Expression
Biased expression in brain (RPKM 29.6), kidney (RPKM 21.6) and 13 other tissues See more
Orthologs
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Genomic context

See ANK2 in Genome Data Viewer
Location:
4q25-q26
Exon count:
61
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (112705622..113383736)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113626778..114304892)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene oligosaccharyltransferase complex subunit pseudogene 4 Neighboring gene GET1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 864 Neighboring gene ribosomal protein L32 pseudogene 13 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma pseudogene Neighboring gene TATA-box binding protein associated factor 4b pseudogene Neighboring gene ribosomal protein L7a pseudogene 30 Neighboring gene uncharacterized LOC102723896 Neighboring gene ANK2 antisense RNA 1 Neighboring gene microRNA 1243 Neighboring gene microRNA 8082 Neighboring gene ribosomal protein S26 pseudogene 25 Neighboring gene uncharacterized LOC105377374 Neighboring gene Sharpr-MPRA regulatory region 2369 Neighboring gene RNA, 7SL, cytoplasmic 184, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
GeneReviews: Not available
Cardiac arrhythmia, ankyrin B-related
MedGen: C1970119 OMIM: 600919 GeneReviews: Long QT Syndrome
Compare labs
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
GeneReviews: Not available
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2019-05-22)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2019-05-22)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11832, FLJ38277, FLJ46169, DKFZp686P0948, DKFZp686M09125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ion channel binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphorylation-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables spectrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables spectrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in SA node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in SA node cell to atrial cardiac muscle cell communication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-tubule organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in atrial cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial cardiac muscle cell to AV node cell communication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in atrial septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular protein localization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
involved_in membrane depolarization during SA node cell action potential TAS
Traceable Author Statement
more info
PubMed 
involved_in paranodal junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of potassium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to M-band ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to organelle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of SA node cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of atrial cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of calcium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cardiac muscle cell contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle contraction by calcium ion signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate by cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate by cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein stability IC
Inferred by Curator
more info
PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to methylmercury IEA
Inferred from Electronic Annotation
more info
 
involved_in sarcoplasmic reticulum calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in ventricular cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in A band ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in M band ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in costamere ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
 
located_in sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ankyrin-2
Names
ankyrin 2, neuronal
ankyrin B
ankyrin, brain
ankyrin-2, nonerythrocytic
non-erythroid ankyrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009006.2 RefSeqGene

    Range
    5001..570658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_327

mRNA and Protein(s)

  1. NM_001127493.3NP_001120965.1  ankyrin-2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS54796.1
    UniProtKB/Swiss-Prot
    Q01484
    Related
    ENSP00000421067.1, ENST00000506722.5
    Conserved Domains (9) summary
    pfam06390
    Location:16291786
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9571094
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:508533
    ANK; ankyrin repeats
    COG0666
    Location:285483
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14731556
    Death_ank2; Death domain of Ankyrin-2
    pfam12796
    Location:216307
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1663
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
  2. NM_001148.6NP_001139.3  ankyrin-2 isoform 1

    See identical proteins and their annotated locations for NP_001139.3

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS3702.1
    UniProtKB/Swiss-Prot
    Q01484
    Related
    ENSP00000349588.4, ENST00000357077.9
    Conserved Domains (11) summary
    pfam06390
    Location:37233880
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    pfam09528
    Location:20712594
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    smart00218
    Location:9661103
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:529554
    ANK; ankyrin repeats
    COG0666
    Location:306504
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:35673650
    Death_ank2; Death domain of Ankyrin-2
    pfam12796
    Location:237328
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:3784
    Ank_4; Ankyrin repeats (many copies)
    pfam15718
    Location:18772169
    DUF4673; Domain of unknown function (DUF4673)
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
  3. NM_001354225.2NP_001341154.1  ankyrin-2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16421799
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9701107
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14861569
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  4. NM_001354228.2NP_001341157.1  ankyrin-2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Related
    ENSP00000500102.1, ENST00000671727.1
    Conserved Domains (6) summary
    pfam06390
    Location:16051742
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9661070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14491532
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  5. NM_001354230.2NP_001341159.1  ankyrin-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16311788
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9921096
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14751558
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514565
    Ank_4; Ankyrin repeats (many copies)
  6. NM_001354231.2NP_001341160.1  ankyrin-2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16521789
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9801117
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14961579
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514565
    Ank_4; Ankyrin repeats (many copies)
  7. NM_001354232.2NP_001341161.1  ankyrin-2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Related
    ENSP00000500954.1, ENST00000671762.1
    Conserved Domains (6) summary
    pfam06390
    Location:16501787
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9781115
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14941577
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  8. NM_001354235.2NP_001341164.1  ankyrin-2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16371774
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9651102
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14811564
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  9. NM_001354236.2NP_001341165.1  ankyrin-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16041761
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9651069
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14481531
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  10. NM_001354237.2NP_001341166.1  ankyrin-2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16641821
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9921129
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:15081591
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514565
    Ank_4; Ankyrin repeats (many copies)
  11. NM_001354239.2NP_001341168.1  ankyrin-2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16281765
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9561093
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14721555
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478529
    Ank_4; Ankyrin repeats (many copies)
  12. NM_001354240.2NP_001341169.1  ankyrin-2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Related
    ENSP00000499996.1, ENST00000673240.1
    Conserved Domains (6) summary
    pfam06390
    Location:16531810
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9811118
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14971580
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514565
    Ank_4; Ankyrin repeats (many copies)
  13. NM_001354241.2NP_001341170.1  ankyrin-2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093617, AC093879, AC093900
    Related
    ENSP00000499869.1, ENST00000672779.1
    Conserved Domains (6) summary
    pfam06390
    Location:16531810
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9811118
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14971580
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514565
    Ank_4; Ankyrin repeats (many copies)
  14. NM_001354242.2NP_001341171.1  ankyrin-2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16521809
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9801117
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14961579
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514565
    Ank_4; Ankyrin repeats (many copies)
  15. NM_001354243.2NP_001341172.1  ankyrin-2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500881.1, ENST00000672402.1
    Conserved Domains (6) summary
    pfam06390
    Location:16171754
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9451082
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14611544
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478529
    Ank_4; Ankyrin repeats (many copies)
  16. NM_001354244.2NP_001341173.1  ankyrin-2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16161753
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9441081
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14601543
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478529
    Ank_4; Ankyrin repeats (many copies)
  17. NM_001354245.2NP_001341174.1  ankyrin-2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Related
    ENSP00000499959.1, ENST00000672045.1
    Conserved Domains (6) summary
    pfam06390
    Location:15841741
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9451049
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14281511
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:565616
    Ank_4; Ankyrin repeats (many copies)
  18. NM_001354246.2NP_001341175.1  ankyrin-2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16371794
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9651102
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14811564
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  19. NM_001354249.2NP_001341178.1  ankyrin-2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000499837.1, ENST00000672088.1
    Conserved Domains (6) summary
    pfam06390
    Location:15761733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9371041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14201503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470521
    Ank_4; Ankyrin repeats (many copies)
  20. NM_001354252.2NP_001341181.1  ankyrin-2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16281785
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9561093
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14721555
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478529
    Ank_4; Ankyrin repeats (many copies)
  21. NM_001354253.2NP_001341182.1  ankyrin-2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500420.1, ENST00000672350.1
    Conserved Domains (6) summary
    pfam06390
    Location:15631720
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9241028
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14071490
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:544595
    Ank_4; Ankyrin repeats (many copies)
  22. NM_001354254.2NP_001341183.1  ankyrin-2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16211778
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9491086
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14651548
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478529
    Ank_4; Ankyrin repeats (many copies)
  23. NM_001354255.2NP_001341184.1  ankyrin-2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500459.1, ENST00000671825.1
    Conserved Domains (6) summary
    pfam06390
    Location:16171774
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9451082
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14611544
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478529
    Ank_4; Ankyrin repeats (many copies)
  24. NM_001354256.2NP_001341185.1  ankyrin-2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (8) summary
    pfam06390
    Location:16161773
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9441081
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:383668
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:14601543
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:740792
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:13021431
    UPA_2; UPA domain
    cl39094
    Location:540764
    Ank_2; Ankyrin repeats (3 copies)
  25. NM_001354257.2NP_001341186.1  ankyrin-2 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500833.1, ENST00000671854.1
    Conserved Domains (6) summary
    pfam06390
    Location:15511708
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9121016
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:13951478
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:544595
    Ank_4; Ankyrin repeats (many copies)
  26. NM_001354258.2NP_001341187.1  ankyrin-2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Related
    ENSP00000500937.1, ENST00000672366.1
    Conserved Domains (6) summary
    pfam06390
    Location:16051762
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9661070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14491532
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  27. NM_001354260.2NP_001341189.1  ankyrin-2 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500544.1, ENST00000672356.1
    Conserved Domains (6) summary
    pfam06390
    Location:15431700
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9041008
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:13871470
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:536587
    Ank_4; Ankyrin repeats (many copies)
  28. NM_001354261.2NP_001341190.1  ankyrin-2 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093617, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:15911748
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9521056
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:213338
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14351518
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:416447
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:485536
    Ank_4; Ankyrin repeats (many copies)
  29. NM_001354262.2NP_001341191.1  ankyrin-2 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500378.1, ENST00000672312.1
    Conserved Domains (6) summary
    pfam06390
    Location:15841741
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9451049
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14281511
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478529
    Ank_4; Ankyrin repeats (many copies)
  30. NM_001354264.2NP_001341193.1  ankyrin-2 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500473.1, ENST00000672221.1
    Conserved Domains (6) summary
    pfam06390
    Location:15831740
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9371041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14271510
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470521
    Ank_4; Ankyrin repeats (many copies)
  31. NM_001354265.2NP_001341194.1  ankyrin-2 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:16371794
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9651102
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14811564
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  32. NM_001354266.2NP_001341195.1  ankyrin-2 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500527.1, ENST00000672955.1
    Conserved Domains (6) summary
    pfam06390
    Location:15761733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9371041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14201503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470521
    Ank_4; Ankyrin repeats (many copies)
  33. NM_001354267.2NP_001341196.1  ankyrin-2 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500926.1, ENST00000671704.1
    Conserved Domains (6) summary
    pfam06390
    Location:15761733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9371041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14201503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470521
    Ank_4; Ankyrin repeats (many copies)
  34. NM_001354268.2NP_001341197.1  ankyrin-2 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Related
    ENSP00000500311.1, ENST00000672854.1
    Conserved Domains (6) summary
    pfam06390
    Location:15721729
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9331037
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14161499
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:565616
    Ank_4; Ankyrin repeats (many copies)
  35. NM_001354269.3NP_001341198.1  ankyrin-2 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900, AC106864
    Conserved Domains (7) summary
    pfam06390
    Location:15671724
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:8951032
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    COG0666
    Location:1092
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:223348
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14111494
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:624655
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:188249
    Ank_4; Ankyrin repeats (many copies)
  36. NM_001354270.2NP_001341199.1  ankyrin-2 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500843.1, ENST00000673546.1
    Conserved Domains (6) summary
    pfam06390
    Location:15631720
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9241028
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14071490
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:544595
    Ank_4; Ankyrin repeats (many copies)
  37. NM_001354271.2NP_001341200.1  ankyrin-2 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500528.1, ENST00000671951.1
    Conserved Domains (6) summary
    pfam06390
    Location:15431700
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9041008
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:13871470
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:536587
    Ank_4; Ankyrin repeats (many copies)
  38. NM_001354272.2NP_001341201.1  ankyrin-2 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:15951752
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9561060
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14391522
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478529
    Ank_4; Ankyrin repeats (many copies)
  39. NM_001354273.2NP_001341202.1  ankyrin-2 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:15381695
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:8991003
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:13821465
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:628659
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:192253
    Ank_4; Ankyrin repeats (many copies)
  40. NM_001354274.2NP_001341203.1  ankyrin-2 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500112.1, ENST00000673453.1
    Conserved Domains (6) summary
    pfam06390
    Location:15601697
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9321036
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14041487
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470521
    Ank_4; Ankyrin repeats (many copies)
  41. NM_001354275.2NP_001341204.1  ankyrin-2 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500712.1, ENST00000671756.1
    Conserved Domains (6) summary
    pfam06390
    Location:15841741
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9451049
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14281511
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478529
    Ank_4; Ankyrin repeats (many copies)
  42. NM_001354276.2NP_001341205.1  ankyrin-2 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500908.1, ENST00000672731.1
    Conserved Domains (9) summary
    pfam06390
    Location:15761733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9371041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:375660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:14201503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732784
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:12621391
    UPA_2; UPA domain
    cl39094
    Location:532756
    Ank_2; Ankyrin repeats (3 copies)
  43. NM_001354277.2NP_001341206.1  ankyrin-2 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000499986.1, ENST00000671893.1
    Conserved Domains (6) summary
    pfam06390
    Location:15101667
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:871975
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:13541437
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:599630
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:666718
    Ank_4; Ankyrin repeats (many copies)
  44. NM_001354278.2NP_001341207.1  ankyrin-2 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Related
    ENSP00000500007.1, ENST00000673353.1
    Conserved Domains (3) summary
    pfam06390
    Location:814971
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:175279
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:658741
    Death_ank2; Death domain of Ankyrin-2
  45. NM_001354279.2NP_001341208.1  ankyrin-2 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Related
    ENSP00000500111.1, ENST00000673231.1
    Conserved Domains (3) summary
    pfam06390
    Location:826983
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:187291
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:670753
    Death_ank2; Death domain of Ankyrin-2
  46. NM_001354280.2NP_001341209.1  ankyrin-2 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Related
    ENSP00000500832.1, ENST00000673048.1
    Conserved Domains (3) summary
    pfam06390
    Location:821978
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:175279
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:665748
    Death_ank2; Death domain of Ankyrin-2
  47. NM_001354281.2NP_001341210.1  ankyrin-2 isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Consensus CDS
    CCDS87250.1
    Related
    ENSP00000426944.1, ENST00000509550.5
    Conserved Domains (3) summary
    pfam06390
    Location:814971
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:175279
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:658741
    Death_ank2; Death domain of Ankyrin-2
  48. NM_001354282.2NP_001341211.1  ankyrin-2 isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Related
    ENSP00000499979.1, ENST00000672411.1
    Conserved Domains (3) summary
    pfam06390
    Location:826983
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:187291
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:670753
    Death_ank2; Death domain of Ankyrin-2
  49. NM_001386142.1NP_001373071.1  ankyrin-2 isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500245.1, ENST00000673298.1
  50. NM_001386143.1NP_001373072.1  ankyrin-2 isoform 51

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000499928.1, ENST00000671793.1
  51. NM_001386144.1NP_001373073.1  ankyrin-2 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
  52. NM_001386146.1NP_001373075.1  ankyrin-2 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
  53. NM_001386147.1NP_001373076.1  ankyrin-2 isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093617, AC093900
  54. NM_001386148.2NP_001373077.1  ankyrin-2 isoform 55

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900, AC106864
  55. NM_001386149.1NP_001373078.1  ankyrin-2 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
  56. NM_001386150.1NP_001373079.1  ankyrin-2 isoform 57

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
  57. NM_001386151.1NP_001373080.1  ankyrin-2 isoform 58

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
  58. NM_001386152.1NP_001373081.1  ankyrin-2 isoform 59

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
  59. NM_001386153.1NP_001373082.1  ankyrin-2 isoform 60

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
  60. NM_001386154.1NP_001373083.1  ankyrin-2 isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
  61. NM_001386156.1NP_001373085.1  ankyrin-2 isoform 62

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000499943.1, ENST00000672684.1
  62. NM_001386157.1NP_001373086.1  ankyrin-2 isoform 63

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000499967.1, ENST00000672986.1
  63. NM_001386158.1NP_001373087.1  ankyrin-2 isoform 64

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
  64. NM_001386160.1NP_001373089.1  ankyrin-2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093617, AC093900
  65. NM_001386161.1NP_001373090.1  ankyrin-2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (8) summary
    pfam06390
    Location:16161773
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9441081
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:383668
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:14601543
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:740792
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:13021431
    UPA_2; UPA domain
    cl39094
    Location:540764
    Ank_2; Ankyrin repeats (3 copies)
  66. NM_001386162.1NP_001373091.1  ankyrin-2 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:15761733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9371041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:375660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:14201503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732784
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:12621391
    UPA_2; UPA domain
    cl39094
    Location:532756
    Ank_2; Ankyrin repeats (3 copies)
  67. NM_001386166.1NP_001373095.1  ankyrin-2 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC093900
    Related
    ENST00000683972.1
  68. NM_001386167.1NP_001373096.1  ankyrin-2 isoform 66

    Status: REVIEWED

    Source sequence(s)
    AC093900
  69. NM_001386174.1NP_001373103.1  ankyrin-2 isoform 67

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093617, AC093900
    Conserved Domains (14) summary
    pfam06390
    Location:37703884
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:10131150
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PTZ00449
    Location:17172161
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03095
    Location:421706
    PHA03095; ankyrin-like protein; Provisional
    PRK14949
    Location:31963442
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd08804
    Location:36143697
    Death_ank2; Death domain of Ankyrin-2
    TIGR00600
    Location:30313565
    rad2; DNA excision repair protein (rad2)
    sd00045
    Location:447478
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:778830
    Ank_4; Ankyrin repeats (many copies)
    pfam15402
    Location:24932634
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam17809
    Location:13711500
    UPA_2; UPA domain
    NF033804
    Location:18432027
    Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
    NF033838
    Location:15491922
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
    cl39094
    Location:578802
    Ank_2; Ankyrin repeats (3 copies)
  70. NM_001386175.1NP_001373104.1  ankyrin-2 isoform 68

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093617, AC093900
    Conserved Domains (15) summary
    pfam06390
    Location:37623876
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:10051142
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PTZ00449
    Location:17092153
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03095
    Location:413698
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:37179
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK14949
    Location:31883434
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd08804
    Location:36063689
    Death_ank2; Death domain of Ankyrin-2
    TIGR00600
    Location:30233557
    rad2; DNA excision repair protein (rad2)
    sd00045
    Location:439470
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:770822
    Ank_4; Ankyrin repeats (many copies)
    pfam15402
    Location:24852626
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam17809
    Location:13631492
    UPA_2; UPA domain
    NF033804
    Location:18352019
    Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
    NF033838
    Location:15411914
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
    cl39094
    Location:570794
    Ank_2; Ankyrin repeats (3 copies)
  71. NM_001386186.2NP_001373115.1  ankyrin-2 isoform 69

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900, AC106864
  72. NM_001386187.2NP_001373116.1  ankyrin-2 isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900, AC106864
  73. NM_020977.5NP_066187.2  ankyrin-2 isoform 2

    See identical proteins and their annotated locations for NP_066187.2

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS43261.1
    UniProtKB/Swiss-Prot
    Q01484
    Related
    ENSP00000378044.3, ENST00000394537.7
    Conserved Domains (8) summary
    pfam06390
    Location:16381795
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9661103
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:529554
    ANK; ankyrin repeats
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14821565
    Death_ank2; Death domain of Ankyrin-2
    pfam12796
    Location:237328
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:3784
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    112705622..113383736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008071.2XP_016863560.1  ankyrin-2 isoform X4

  2. XM_017008074.2XP_016863563.1  ankyrin-2 isoform X7

  3. XM_017008075.2XP_016863564.1  ankyrin-2 isoform X8

  4. XM_017008072.2XP_016863561.1  ankyrin-2 isoform X5

  5. XM_017008080.2XP_016863569.1  ankyrin-2 isoform X18

  6. XM_017008077.2XP_016863566.1  ankyrin-2 isoform X10

    Related
    ENSP00000499982.1, ENST00000672209.1
  7. XM_024454021.1XP_024309789.1  ankyrin-2 isoform X17

    Conserved Domains (6) summary
    pfam06390
    Location:16041761
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9651069
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14481531
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  8. XM_024454016.1XP_024309784.1  ankyrin-2 isoform X3

    Conserved Domains (11) summary
    pfam06390
    Location:37353849
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9781115
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:35793662
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
    pfam15402
    Location:24582599
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    cl26247
    Location:31613407
    DNA_pol3_delta2; DNA polymerase III, delta subunit
    cl26305
    Location:29963530
    XPG_I; XPG I-region
    cl26511
    Location:15452172
    Neuromodulin_N; Gap junction protein N-terminal region
    cl28033
    Location:16901969
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  9. XM_024454017.1XP_024309785.1  ankyrin-2 isoform X12

    Conserved Domains (6) summary
    pfam06390
    Location:16501787
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9781115
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14941577
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  10. XM_017008073.2XP_016863562.1  ankyrin-2 isoform X6

  11. XM_017008076.2XP_016863565.1  ankyrin-2 isoform X9

  12. XM_017008078.2XP_016863567.1  ankyrin-2 isoform X13

  13. XM_005262945.3XP_005263002.1  ankyrin-2 isoform X11

    Related
    ENSP00000499887.1, ENST00000671882.1
    Conserved Domains (12) summary
    pfam06390
    Location:36903847
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    pfam09528
    Location:20382561
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    smart00218
    Location:9661070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:529554
    ANK; ankyrin repeats
    COG0666
    Location:306504
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:35343617
    Death_ank2; Death domain of Ankyrin-2
    pfam06583
    Location:16911962
    Neogenin_C; Neogenin C-terminus
    pfam12796
    Location:237328
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:3784
    Ank_4; Ankyrin repeats (many copies)
    pfam15718
    Location:18442136
    DUF4673; Domain of unknown function (DUF4673)
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
  14. XM_024454018.1XP_024309786.1  ankyrin-2 isoform X14

    Conserved Domains (6) summary
    pfam06390
    Location:16051742
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9661070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14491532
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  15. XM_024454020.1XP_024309788.1  ankyrin-2 isoform X16

    Conserved Domains (6) summary
    pfam06390
    Location:16051762
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9661070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14491532
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499550
    Ank_4; Ankyrin repeats (many copies)
  16. XM_024454022.1XP_024309790.1  ankyrin-2 isoform X19

    Conserved Domains (6) summary
    pfam06390
    Location:15841741
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9451049
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14281511
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:565616
    Ank_4; Ankyrin repeats (many copies)
  17. XM_024454023.1XP_024309791.1  ankyrin-2 isoform X20

    Conserved Domains (6) summary
    pfam06390
    Location:15381695
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:8991003
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:13821465
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:628659
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:192253
    Ank_4; Ankyrin repeats (many copies)
  18. XM_024454019.1XP_024309787.1  ankyrin-2 isoform X15

    Conserved Domains (6) summary
    pfam06390
    Location:16311788
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:9921096
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:14751558
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514565
    Ank_4; Ankyrin repeats (many copies)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001386173.1: Suppressed sequence

    Description
    NM_001386173.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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