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ANK2 ankyrin 2 [ Homo sapiens (human) ]

Gene ID: 287, updated on 7-Sep-2023

Summary

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Official Symbol
ANK2provided by HGNC
Official Full Name
ankyrin 2provided by HGNC
Primary source
HGNC:HGNC:493
See related
Ensembl:ENSG00000145362 MIM:106410; AllianceGenome:HGNC:493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LQT4; ANK-2; FAP87; CFAP87; brank-2
Summary
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
Expression
Biased expression in brain (RPKM 29.6), kidney (RPKM 21.6) and 13 other tissues See more
Orthologs
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Genomic context

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See ANK2 in Genome Data Viewer
Location:
4q25-q26
Exon count:
61
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (112705622..113383736)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (116013980..116692458)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113626778..114304892)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113625759-113626458 Neighboring gene Sharpr-MPRA regulatory region 87 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:113632589-113633089 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113639815-113640314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113659291-113660232 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113660233-113661174 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113671787-113672487 Neighboring gene GET1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113678316-113679129 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113679943-113680756 Neighboring gene Sharpr-MPRA regulatory region 864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:113695074-113695600 Neighboring gene ribosomal protein L32 pseudogene 13 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:113738957-113739482 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:113739483-113740006 Neighboring gene TATA-box binding protein associated factor 4b pseudogene Neighboring gene ribosomal protein L7a pseudogene 30 Neighboring gene uncharacterized LOC102723896 Neighboring gene Sharpr-MPRA regulatory region 8329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:113879232-113879899 Neighboring gene uncharacterized LOC124900761 Neighboring gene NANOG hESC enhancer GRCh37_chr4:113945514-113946051 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:113981923-113982493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:113985214-113985864 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:113987456-113987956 Neighboring gene ANK2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:114066308-114066916 Neighboring gene microRNA 1243 Neighboring gene microRNA 8082 Neighboring gene ribosomal protein S26 pseudogene 25 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:114213551-114214070 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:114214071-114214590 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:114274931-114276130 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:114276560-114277759 Neighboring gene NANOG hESC enhancer GRCh37_chr4:114306634-114307363 Neighboring gene uncharacterized LOC105377374 Neighboring gene Sharpr-MPRA regulatory region 2369 Neighboring gene RNA, 7SL, cytoplasmic 184, pseudogene Neighboring gene RNA, U1 small nuclear 138, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks. Teunissen MWA, et al. Hum Mol Genet, 2023 Jul 4. PMID 37195288, Free PMC Article
  2. Established Loss-of-Function Variants in ANK2-Encoded Ankyrin-B Rarely Cause a Concerning Cardiac Phenotype in Humans. Giudicessi JR, et al. Circ Genom Precis Med, 2020 Apr. PMID 32164423
  3. Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function. Sucharski HC, et al. Biomolecules, 2020 Jan 31. PMID 32023981, Free PMC Article
  4. Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome. Swayne LA, et al. Circ Cardiovasc Genet, 2017 Jan. PMID 28196901, Free PMC Article
  5. Rare Variants in ANK2 Associated With Various Inherited Arrhythmia Syndromes. Watanabe H, et al. Circ J, 2016 Nov 25. PMID 27818464

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.
    Title: ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.
  2. Human ankyrins and their contribution to disease biology: An update.
    Title: Human ankyrins and their contribution to disease biology: An update.
  3. lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression.
    Title: lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression.
  4. Established Loss-of-Function Variants in ANK2-Encoded Ankyrin-B Rarely Cause a Concerning Cardiac Phenotype in Humans.
    Title: Established Loss-of-Function Variants in ANK2-Encoded Ankyrin-B Rarely Cause a Concerning Cardiac Phenotype in Humans.
  5. Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function.
    Title: Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function.
  6. Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.
    Title: Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.
  7. ANK2 Hypermethylation in Canine Mammary Tumors and Human Breast Cancer.
    Title: ANK2 Hypermethylation in Canine Mammary Tumors and Human Breast Cancer.
  8. Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study.
    Title: Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study.
  9. These novel findings have important implications for understanding the role of AnkB and Cav2.1 in the regulation of neuronal function in health and disease.
    Title: Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels.
  10. findings introduce what we believe to be a new pathway for Arrhythmogenic cardiomyopathy, a role of ankyrin-B in cardiac structure and signaling, a molecular link between ankyrin-B and beta-catenin, and evidence for targeted activation of the WNT/beta-catenin pathway as a potential treatment for this disease.
    Title: Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cardiac arrhythmia, ankyrin-B-related
MedGen: C1970119 OMIM: 600919 GeneReviews: Long QT Syndrome
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2019-05-22)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2019-05-22)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
EBI GWAS Catalog
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11832, FLJ38277, FLJ46169, DKFZp686P0948, DKFZp686M09125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphorylation-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables spectrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables spectrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in SA node cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in SA node cell to atrial cardiac muscle cell communication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T-tubule organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in atrial cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in atrial cardiac muscle cell to AV node cell communication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in atrial septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in membrane depolarization during SA node cell action potential TAS
Traceable Author Statement
more info
 PubMed 
involved_in paranodal junction assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of potassium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to M-band ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to organelle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of SA node cell action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of atrial cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of calcium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cardiac muscle cell contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cardiac muscle contraction by calcium ion signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of heart rate by cardiac conduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of heart rate by cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein stability IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to methylmercury IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcoplasmic reticulum calcium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in ventricular cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in A band ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in M band ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in costamere ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ankyrin-2
Names
ankyrin 2, neuronal
ankyrin B
ankyrin, brain
ankyrin-2, nonerythrocytic
non-erythroid ankyrin

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009006.2 RefSeqGene

    Range
    5001..570658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_327

mRNA and Protein(s)

  1. NM_001127493.3 → NP_001120965.1  ankyrin-2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS54796.1
    UniProtKB/Swiss-Prot
    Q01484
    Related
    ENSP00000421067.1, ENST00000506722.5
    Conserved Domains (9) summary
    pfam06390
    Location:1629 → 1786
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:957 → 1094
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:508 → 533
    ANK; ankyrin repeats
    COG0666
    Location:285 → 483
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1473 → 1556
    Death_ank2; Death domain of Ankyrin-2
    pfam12796
    Location:216 → 307
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:16 → 63
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]

  2. NM_001148.6 → NP_001139.3  ankyrin-2 isoform 1

    See identical proteins and their annotated locations for NP_001139.3

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS3702.1
    UniProtKB/Swiss-Prot
    Q01484, Q01485, Q08AC7, Q08AC8, Q7Z3L5
    UniProtKB/TrEMBL
    I6L894
    Related
    ENSP00000349588.4, ENST00000357077.9
    Conserved Domains (11) summary
    pfam06390
    Location:3723 → 3880
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    pfam09528
    Location:2071 → 2594
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    smart00218
    Location:966 → 1103
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:529 → 554
    ANK; ankyrin repeats
    COG0666
    Location:306 → 504
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:3567 → 3650
    Death_ank2; Death domain of Ankyrin-2
    pfam12796
    Location:237 → 328
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:37 → 84
    Ank_4; Ankyrin repeats (many copies)
    pfam15718
    Location:1877 → 2169
    DUF4673; Domain of unknown function (DUF4673)
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]

  3. NM_001354225.2 → NP_001341154.1  ankyrin-2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1642 → 1799
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:970 → 1107
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1486 → 1569
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499 → 550
    Ank_4; Ankyrin repeats (many copies)

  4. NM_001354228.2 → NP_001341157.1  ankyrin-2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS93591.1
    UniProtKB/TrEMBL
    A0A5F9ZH70
    Related
    ENSP00000500102.1, ENST00000671727.1
    Conserved Domains (6) summary
    pfam06390
    Location:1605 → 1742
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:966 → 1070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1449 → 1532
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499 → 550
    Ank_4; Ankyrin repeats (many copies)

  5. NM_001354230.2 → NP_001341159.1  ankyrin-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    UniProtKB/TrEMBL
    A0A994J7V8
    Conserved Domains (6) summary
    pfam06390
    Location:1631 → 1788
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:992 → 1096
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242 → 367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1475 → 1558
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445 → 476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514 → 565
    Ank_4; Ankyrin repeats (many copies)

  6. NM_001354231.2 → NP_001341160.1  ankyrin-2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    UniProtKB/TrEMBL
    A0A994J7V8
    Conserved Domains (6) summary
    pfam06390
    Location:1652 → 1789
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:980 → 1117
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242 → 367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1496 → 1579
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445 → 476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514 → 565
    Ank_4; Ankyrin repeats (many copies)

  7. NM_001354232.2 → NP_001341161.1  ankyrin-2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS93590.1
    UniProtKB/TrEMBL
    A0A5F9ZI81
    Related
    ENSP00000500954.1, ENST00000671762.1
    Conserved Domains (6) summary
    pfam06390
    Location:1650 → 1787
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:978 → 1115
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1494 → 1577
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499 → 550
    Ank_4; Ankyrin repeats (many copies)

  8. NM_001354235.2 → NP_001341164.1  ankyrin-2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1637 → 1774
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:965 → 1102
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1481 → 1564
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499 → 550
    Ank_4; Ankyrin repeats (many copies)

  9. NM_001354236.2 → NP_001341165.1  ankyrin-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1604 → 1761
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:965 → 1069
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1448 → 1531
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499 → 550
    Ank_4; Ankyrin repeats (many copies)

  10. NM_001354237.2 → NP_001341166.1  ankyrin-2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    UniProtKB/TrEMBL
    A0A994J7V8
    Conserved Domains (6) summary
    pfam06390
    Location:1664 → 1821
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:992 → 1129
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242 → 367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1508 → 1591
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445 → 476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514 → 565
    Ank_4; Ankyrin repeats (many copies)

  11. NM_001354239.2 → NP_001341168.1  ankyrin-2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1628 → 1765
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:956 → 1093
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1472 → 1555
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478 → 529
    Ank_4; Ankyrin repeats (many copies)

  12. NM_001354240.2 → NP_001341169.1  ankyrin-2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS93595.1
    UniProtKB/TrEMBL
    A0A5F9ZH39, A0A994J7V8
    Related
    ENSP00000499996.1, ENST00000673240.1
    Conserved Domains (6) summary
    pfam06390
    Location:1653 → 1810
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:981 → 1118
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242 → 367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1497 → 1580
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445 → 476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514 → 565
    Ank_4; Ankyrin repeats (many copies)

  13. NM_001354241.2 → NP_001341170.1  ankyrin-2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093617, AC093879, AC093900
    Consensus CDS
    CCDS93589.1
    UniProtKB/TrEMBL
    A0A5F9ZGY1
    Related
    ENSP00000499869.1, ENST00000672779.1
    Conserved Domains (6) summary
    pfam06390
    Location:1653 → 1810
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:981 → 1118
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242 → 367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1497 → 1580
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445 → 476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514 → 565
    Ank_4; Ankyrin repeats (many copies)

  14. NM_001354242.2 → NP_001341171.1  ankyrin-2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    UniProtKB/TrEMBL
    A0A994J7V8
    Conserved Domains (6) summary
    pfam06390
    Location:1652 → 1809
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:980 → 1117
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:242 → 367
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1496 → 1579
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445 → 476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:514 → 565
    Ank_4; Ankyrin repeats (many copies)

  15. NM_001354243.2 → NP_001341172.1  ankyrin-2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93573.1
    UniProtKB/TrEMBL
    A0A5F9ZI56
    Related
    ENSP00000500881.1, ENST00000672402.1
    Conserved Domains (6) summary
    pfam06390
    Location:1617 → 1754
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:945 → 1082
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1461 → 1544
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478 → 529
    Ank_4; Ankyrin repeats (many copies)

  16. NM_001354244.2 → NP_001341173.1  ankyrin-2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1616 → 1753
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:944 → 1081
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1460 → 1543
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478 → 529
    Ank_4; Ankyrin repeats (many copies)

  17. NM_001354245.2 → NP_001341174.1  ankyrin-2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS93593.1
    UniProtKB/TrEMBL
    A0A5F9ZH17
    Related
    ENSP00000499959.1, ENST00000672045.1
    Conserved Domains (6) summary
    pfam06390
    Location:1584 → 1741
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:945 → 1049
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1428 → 1511
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:565 → 616
    Ank_4; Ankyrin repeats (many copies)

  18. NM_001354246.2 → NP_001341175.1  ankyrin-2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1637 → 1794
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:965 → 1102
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1481 → 1564
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499 → 550
    Ank_4; Ankyrin repeats (many copies)

  19. NM_001354249.2 → NP_001341178.1  ankyrin-2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93582.1
    UniProtKB/TrEMBL
    A0A5F9ZGS5
    Related
    ENSP00000499837.1, ENST00000672088.1
    Conserved Domains (6) summary
    pfam06390
    Location:1576 → 1733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198 → 323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1420 → 1503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470 → 521
    Ank_4; Ankyrin repeats (many copies)

  20. NM_001354252.2 → NP_001341181.1  ankyrin-2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1628 → 1785
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:956 → 1093
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1472 → 1555
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478 → 529
    Ank_4; Ankyrin repeats (many copies)

  21. NM_001354253.2 → NP_001341182.1  ankyrin-2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93577.1
    UniProtKB/TrEMBL
    A0A5F9ZHL3
    Related
    ENSP00000500420.1, ENST00000672350.1
    Conserved Domains (6) summary
    pfam06390
    Location:1563 → 1720
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:924 → 1028
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1407 → 1490
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:544 → 595
    Ank_4; Ankyrin repeats (many copies)

  22. NM_001354254.2 → NP_001341183.1  ankyrin-2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1621 → 1778
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:949 → 1086
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1465 → 1548
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478 → 529
    Ank_4; Ankyrin repeats (many copies)

  23. NM_001354255.2 → NP_001341184.1  ankyrin-2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93574.1
    UniProtKB/TrEMBL
    A0A024RDI4, A0A5F9ZHJ6
    Related
    ENSP00000500459.1, ENST00000671825.1
    Conserved Domains (6) summary
    pfam06390
    Location:1617 → 1774
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:945 → 1082
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1461 → 1544
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478 → 529
    Ank_4; Ankyrin repeats (many copies)

  24. NM_001354256.2 → NP_001341185.1  ankyrin-2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (8) summary
    pfam06390
    Location:1616 → 1773
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:944 → 1081
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:383 → 668
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1460 → 1543
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:740 → 792
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1302 → 1431
    UPA_2; UPA domain
    cl39094
    Location:540 → 764
    Ank_2; Ankyrin repeats (3 copies)

  25. NM_001354257.2 → NP_001341186.1  ankyrin-2 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93579.1
    UniProtKB/TrEMBL
    A0A5F9ZI36
    Related
    ENSP00000500833.1, ENST00000671854.1
    Conserved Domains (6) summary
    pfam06390
    Location:1551 → 1708
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:912 → 1016
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1395 → 1478
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:544 → 595
    Ank_4; Ankyrin repeats (many copies)

  26. NM_001354258.2 → NP_001341187.1  ankyrin-2 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS93592.1
    UniProtKB/TrEMBL
    A0A5F9ZI69
    Related
    ENSP00000500937.1, ENST00000672366.1
    Conserved Domains (6) summary
    pfam06390
    Location:1605 → 1762
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:966 → 1070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1449 → 1532
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499 → 550
    Ank_4; Ankyrin repeats (many copies)

  27. NM_001354260.2 → NP_001341189.1  ankyrin-2 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93586.1
    UniProtKB/TrEMBL
    A0A5F9ZHQ3
    Related
    ENSP00000500544.1, ENST00000672356.1
    Conserved Domains (6) summary
    pfam06390
    Location:1543 → 1700
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:904 → 1008
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198 → 323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1387 → 1470
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:536 → 587
    Ank_4; Ankyrin repeats (many copies)

  28. NM_001354261.2 → NP_001341190.1  ankyrin-2 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093617, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1591 → 1748
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:952 → 1056
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:213 → 338
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1435 → 1518
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:416 → 447
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:485 → 536
    Ank_4; Ankyrin repeats (many copies)

  29. NM_001354262.2 → NP_001341191.1  ankyrin-2 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93575.1
    UniProtKB/TrEMBL
    A0A5F9ZHJ4
    Related
    ENSP00000500378.1, ENST00000672312.1
    Conserved Domains (6) summary
    pfam06390
    Location:1584 → 1741
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:945 → 1049
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1428 → 1511
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478 → 529
    Ank_4; Ankyrin repeats (many copies)

  30. NM_001354264.2 → NP_001341193.1  ankyrin-2 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93581.1
    UniProtKB/TrEMBL
    A0A5F9ZHL9
    Related
    ENSP00000500473.1, ENST00000672221.1
    Conserved Domains (6) summary
    pfam06390
    Location:1583 → 1740
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198 → 323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1427 → 1510
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470 → 521
    Ank_4; Ankyrin repeats (many copies)

  31. NM_001354265.2 → NP_001341194.1  ankyrin-2 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    UniProtKB/TrEMBL
    B7Z636
    Conserved Domains (6) summary
    pfam06390
    Location:1637 → 1794
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:965 → 1102
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1481 → 1564
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:499 → 550
    Ank_4; Ankyrin repeats (many copies)

  32. NM_001354266.2 → NP_001341195.1  ankyrin-2 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93583.1
    UniProtKB/TrEMBL
    A0A5F9ZHR2
    Related
    ENSP00000500527.1, ENST00000672955.1
    Conserved Domains (6) summary
    pfam06390
    Location:1576 → 1733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198 → 323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1420 → 1503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470 → 521
    Ank_4; Ankyrin repeats (many copies)

  33. NM_001354267.2 → NP_001341196.1  ankyrin-2 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93583.1
    UniProtKB/TrEMBL
    A0A5F9ZHR2
    Related
    ENSP00000500926.1, ENST00000671704.1
    Conserved Domains (6) summary
    pfam06390
    Location:1576 → 1733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198 → 323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1420 → 1503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470 → 521
    Ank_4; Ankyrin repeats (many copies)

  34. NM_001354268.2 → NP_001341197.1  ankyrin-2 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS93594.1
    UniProtKB/TrEMBL
    A0A5F9ZHE2
    Related
    ENSP00000500311.1, ENST00000672854.1
    Conserved Domains (6) summary
    pfam06390
    Location:1572 → 1729
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:933 → 1037
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1416 → 1499
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:565 → 616
    Ank_4; Ankyrin repeats (many copies)

  35. NM_001354269.3 → NP_001341198.1  ankyrin-2 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900, AC106864
    Conserved Domains (7) summary
    pfam06390
    Location:1567 → 1724
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:895 → 1032
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    COG0666
    Location:10 → 92
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:223 → 348
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1411 → 1494
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:624 → 655
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:188 → 249
    Ank_4; Ankyrin repeats (many copies)

  36. NM_001354270.2 → NP_001341199.1  ankyrin-2 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93578.1
    UniProtKB/TrEMBL
    A0A5F9ZI08
    Related
    ENSP00000500843.1, ENST00000673546.1
    Conserved Domains (6) summary
    pfam06390
    Location:1563 → 1720
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:924 → 1028
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1407 → 1490
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:544 → 595
    Ank_4; Ankyrin repeats (many copies)

  37. NM_001354271.2 → NP_001341200.1  ankyrin-2 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93587.1
    UniProtKB/TrEMBL
    A0A5F9ZHN0
    Related
    ENSP00000500528.1, ENST00000671951.1
    Conserved Domains (6) summary
    pfam06390
    Location:1543 → 1700
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:904 → 1008
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198 → 323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1387 → 1470
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:536 → 587
    Ank_4; Ankyrin repeats (many copies)

  38. NM_001354272.2 → NP_001341201.1  ankyrin-2 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1595 → 1752
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:956 → 1060
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1439 → 1522
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478 → 529
    Ank_4; Ankyrin repeats (many copies)

  39. NM_001354273.2 → NP_001341202.1  ankyrin-2 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Conserved Domains (6) summary
    pfam06390
    Location:1538 → 1695
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:899 → 1003
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1382 → 1465
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:628 → 659
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:192 → 253
    Ank_4; Ankyrin repeats (many copies)

  40. NM_001354274.2 → NP_001341203.1  ankyrin-2 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93585.1
    UniProtKB/TrEMBL
    A0A5F9ZH58
    Related
    ENSP00000500112.1, ENST00000673453.1
    Conserved Domains (6) summary
    pfam06390
    Location:1560 → 1697
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:932 → 1036
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:198 → 323
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1404 → 1487
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:470 → 521
    Ank_4; Ankyrin repeats (many copies)

  41. NM_001354275.2 → NP_001341204.1  ankyrin-2 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93576.1
    UniProtKB/TrEMBL
    A0A5F9ZHY6
    Related
    ENSP00000500712.1, ENST00000671756.1
    Conserved Domains (6) summary
    pfam06390
    Location:1584 → 1741
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:945 → 1049
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:206 → 331
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1428 → 1511
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:478 → 529
    Ank_4; Ankyrin repeats (many copies)

  42. NM_001354276.2 → NP_001341205.1  ankyrin-2 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93584.1
    UniProtKB/TrEMBL
    A0A5F9ZI53
    Related
    ENSP00000500908.1, ENST00000672731.1
    Conserved Domains (9) summary
    pfam06390
    Location:1576 → 1733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:375 → 660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1420 → 1503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732 → 784
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1262 → 1391
    UPA_2; UPA domain
    cl39094
    Location:532 → 756
    Ank_2; Ankyrin repeats (3 copies)

  43. NM_001354277.2 → NP_001341206.1  ankyrin-2 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93588.1
    UniProtKB/TrEMBL
    A0A5F9ZH34
    Related
    ENSP00000499986.1, ENST00000671893.1
    Conserved Domains (9) summary
    pfam06390
    Location:1510 → 1667
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:871 → 975
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02876
    Location:219 → 559
    PHA02876; ankyrin repeat protein; Provisional
    PHA03095
    Location:8 → 327
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1354 → 1437
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:599 → 630
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:666 → 718
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1196 → 1325
    UPA_2; UPA domain
    cl39094
    Location:466 → 690
    Ank_2; Ankyrin repeats (3 copies)

  44. NM_001354278.2 → NP_001341207.1  ankyrin-2 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Consensus CDS
    CCDS93600.1
    UniProtKB/TrEMBL
    A0A5F9ZH18, H0Y8Y2
    Related
    ENSP00000500007.1, ENST00000673353.1
    Conserved Domains (3) summary
    pfam06390
    Location:814 → 971
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:175 → 279
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:658 → 741
    Death_ank2; Death domain of Ankyrin-2

  45. NM_001354279.2 → NP_001341208.1  ankyrin-2 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Consensus CDS
    CCDS93597.1
    UniProtKB/TrEMBL
    A0A5F9ZH99, B7Z2H4
    Related
    ENSP00000500111.1, ENST00000673231.1
    Conserved Domains (3) summary
    pfam06390
    Location:826 → 983
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:187 → 291
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:670 → 753
    Death_ank2; Death domain of Ankyrin-2

  46. NM_001354280.2 → NP_001341209.1  ankyrin-2 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Consensus CDS
    CCDS93599.1
    UniProtKB/TrEMBL
    A0A5F9ZI16, B7Z2H4
    Related
    ENSP00000500832.1, ENST00000673048.1
    Conserved Domains (3) summary
    pfam06390
    Location:821 → 978
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:175 → 279
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:665 → 748
    Death_ank2; Death domain of Ankyrin-2

  47. NM_001354281.2 → NP_001341210.1  ankyrin-2 isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Consensus CDS
    CCDS87250.1
    UniProtKB/TrEMBL
    B7Z2H4, E9PCH6
    Related
    ENSP00000426944.1, ENST00000509550.5
    Conserved Domains (3) summary
    pfam06390
    Location:814 → 971
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:175 → 279
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:658 → 741
    Death_ank2; Death domain of Ankyrin-2

  48. NM_001354282.2 → NP_001341211.1  ankyrin-2 isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900
    Consensus CDS
    CCDS93598.1
    UniProtKB/TrEMBL
    A0A5F9ZH10, B7Z2H4
    Related
    ENSP00000499979.1, ENST00000672411.1
    Conserved Domains (3) summary
    pfam06390
    Location:826 → 983
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:187 → 291
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:670 → 753
    Death_ank2; Death domain of Ankyrin-2

  49. NM_001386142.1 → NP_001373071.1  ankyrin-2 isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000500245.1, ENST00000673298.1
    Conserved Domains (15) summary
    pfam06390
    Location:3645 → 3802
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:932 → 1036
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PTZ00449
    Location:1592 → 2036
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03095
    Location:375 → 660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK14949
    Location:3071 → 3317
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd08804
    Location:3489 → 3572
    Death_ank2; Death domain of Ankyrin-2
    TIGR00600
    Location:2906 → 3440
    rad2; DNA excision repair protein (rad2)
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732 → 784
    Ank_4; Ankyrin repeats (many copies)
    pfam15402
    Location:2368 → 2509
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam17809
    Location:1257 → 1386
    UPA_2; UPA domain
    NF033804
    Location:1718 → 1902
    Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
    NF033838
    Location:1424 → 1797
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
    cl39094
    Location:532 → 756
    Ank_2; Ankyrin repeats (3 copies)

  50. NM_001386143.1 → NP_001373072.1  ankyrin-2 isoform 51

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93572.1
    UniProtKB/TrEMBL
    A0A5F9ZGZ1
    Related
    ENSP00000499928.1, ENST00000671793.1
    Conserved Domains (8) summary
    pfam06390
    Location:1617 → 1754
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:945 → 1082
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:383 → 668
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1461 → 1544
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:740 → 792
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1303 → 1432
    UPA_2; UPA domain
    cl39094
    Location:540 → 764
    Ank_2; Ankyrin repeats (3 copies)

  51. NM_001386144.1 → NP_001373073.1  ankyrin-2 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    UniProtKB/TrEMBL
    A0A994J7V8
    Conserved Domains (8) summary
    pfam06390
    Location:1653 → 1790
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:981 → 1118
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:419 → 704
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1497 → 1580
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445 → 476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:776 → 828
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1339 → 1468
    UPA_2; UPA domain
    cl39094
    Location:576 → 800
    Ank_2; Ankyrin repeats (3 copies)

  52. NM_001386146.1 → NP_001373075.1  ankyrin-2 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:1565 → 1702
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:375 → 660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1409 → 1492
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732 → 784
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1262 → 1391
    UPA_2; UPA domain
    cl39094
    Location:532 → 756
    Ank_2; Ankyrin repeats (3 copies)

  53. NM_001386147.1 → NP_001373076.1  ankyrin-2 isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093617, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:1580 → 1737
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:952 → 1056
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:390 → 675
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:23 → 156
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1424 → 1507
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:416 → 447
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:747 → 799
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1277 → 1406
    UPA_2; UPA domain
    cl39094
    Location:547 → 771
    Ank_2; Ankyrin repeats (3 copies)

  54. NM_001386148.2 → NP_001373077.1  ankyrin-2 isoform 55

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900, AC106864
    Conserved Domains (8) summary
    pfam06390
    Location:1633 → 1790
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:961 → 1098
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:400 → 685
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1477 → 1560
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:426 → 457
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:757 → 809
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1319 → 1448
    UPA_2; UPA domain
    cl39094
    Location:557 → 781
    Ank_2; Ankyrin repeats (3 copies)

  55. NM_001386149.1 → NP_001373078.1  ankyrin-2 isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:1565 → 1722
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:375 → 660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1409 → 1492
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732 → 784
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1262 → 1391
    UPA_2; UPA domain
    cl39094
    Location:532 → 756
    Ank_2; Ankyrin repeats (3 copies)

  56. NM_001386150.1 → NP_001373079.1  ankyrin-2 isoform 57

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:1565 → 1702
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:375 → 660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1409 → 1492
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732 → 784
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1262 → 1391
    UPA_2; UPA domain
    cl39094
    Location:532 → 756
    Ank_2; Ankyrin repeats (3 copies)

  57. NM_001386151.1 → NP_001373080.1  ankyrin-2 isoform 58

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:1543 → 1680
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:904 → 1008
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    COG0666
    Location:6 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1387 → 1470
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:699 → 751
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1229 → 1358
    UPA_2; UPA domain
    pfam12796
    Location:373 → 464
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:448 → 723
    Ank_2; Ankyrin repeats (3 copies)

  58. NM_001386152.1 → NP_001373081.1  ankyrin-2 isoform 59

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    UniProtKB/TrEMBL
    A0A994J7V8
    Conserved Domains (8) summary
    pfam06390
    Location:1657 → 1804
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:985 → 1122
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:419 → 704
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1501 → 1584
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:445 → 476
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:776 → 828
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1343 → 1472
    UPA_2; UPA domain
    cl39094
    Location:576 → 800
    Ank_2; Ankyrin repeats (3 copies)

  59. NM_001386153.1 → NP_001373082.1  ankyrin-2 isoform 60

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:1565 → 1722
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:375 → 660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1409 → 1492
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732 → 784
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1262 → 1391
    UPA_2; UPA domain
    cl39094
    Location:532 → 756
    Ank_2; Ankyrin repeats (3 copies)

  60. NM_001386154.1 → NP_001373083.1  ankyrin-2 isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:1560 → 1717
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:932 → 1036
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:375 → 660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1404 → 1487
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732 → 784
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1257 → 1386
    UPA_2; UPA domain
    cl39094
    Location:532 → 756
    Ank_2; Ankyrin repeats (3 copies)

  61. NM_001386156.1 → NP_001373085.1  ankyrin-2 isoform 62

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93580.1
    UniProtKB/TrEMBL
    A0A5F9ZH03
    Related
    ENSP00000499943.1, ENST00000672684.1
    Conserved Domains (8) summary
    pfam06390
    Location:1551 → 1708
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:912 → 1016
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08804
    Location:1395 → 1478
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:707 → 759
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1237 → 1366
    UPA_2; UPA domain
    pfam12796
    Location:381 → 472
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:456 → 731
    Ank_2; Ankyrin repeats (3 copies)

  62. NM_001386157.1 → NP_001373086.1  ankyrin-2 isoform 63

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Related
    ENSP00000499967.1, ENST00000672986.1
    Conserved Domains (9) summary
    pfam06390
    Location:1510 → 1667
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:871 → 975
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02876
    Location:219 → 559
    PHA02876; ankyrin repeat protein; Provisional
    PHA03095
    Location:8 → 327
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1354 → 1437
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:599 → 630
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:666 → 718
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1196 → 1325
    UPA_2; UPA domain
    cl39094
    Location:466 → 690
    Ank_2; Ankyrin repeats (3 copies)

  63. NM_001386158.1 → NP_001373087.1  ankyrin-2 isoform 64

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:1477 → 1634
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:838 → 942
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:114 → 432
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1321 → 1404
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:566 → 597
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:633 → 685
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1163 → 1292
    UPA_2; UPA domain
    pfam12796
    Location:47 → 134
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:382 → 657
    Ank_2; Ankyrin repeats (3 copies)

  64. NM_001386160.1 → NP_001373089.1  ankyrin-2 isoform 71

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093617, AC093900
    Conserved Domains (9) summary
    pfam06390
    Location:1586 → 1743
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:947 → 1051
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:390 → 675
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:23 → 156
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1430 → 1513
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:416 → 447
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:747 → 799
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1272 → 1401
    UPA_2; UPA domain
    cl39094
    Location:547 → 771
    Ank_2; Ankyrin repeats (3 copies)

  65. NM_001386161.1 → NP_001373090.1  ankyrin-2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Conserved Domains (8) summary
    pfam06390
    Location:1616 → 1773
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:944 → 1081
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:383 → 668
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1460 → 1543
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:409 → 440
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:740 → 792
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1302 → 1431
    UPA_2; UPA domain
    cl39094
    Location:540 → 764
    Ank_2; Ankyrin repeats (3 copies)

  66. NM_001386162.1 → NP_001373091.1  ankyrin-2 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC017007, AC093900
    Consensus CDS
    CCDS93584.1
    UniProtKB/TrEMBL
    A0A5F9ZI53
    Conserved Domains (9) summary
    pfam06390
    Location:1576 → 1733
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:937 → 1041
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:375 → 660
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:6 → 141
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1420 → 1503
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:401 → 432
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:732 → 784
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1262 → 1391
    UPA_2; UPA domain
    cl39094
    Location:532 → 756
    Ank_2; Ankyrin repeats (3 copies)

  67. NM_001386166.1 → NP_001373095.1  ankyrin-2 isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC093900
    Related
    ENST00000683972.1
    Conserved Domains (5) summary
    PTZ00121
    Location:333 → 960
    PTZ00121; MAEBL; Provisional
    PHA03307
    Location:478 → 757
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK14949
    Location:1949 → 2195
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd08804
    Location:2367 → 2450
    Death_ank2; Death domain of Ankyrin-2
    pfam17809
    Location:124 → 253
    UPA_2; UPA domain

  68. NM_001386167.1 → NP_001373096.1  ankyrin-2 isoform 66

    Status: REVIEWED

    Source sequence(s)
    AC093900
    UniProtKB/TrEMBL
    B7Z678
    Conserved Domains (3) summary
    pfam06390
    Location:438 → 552
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd08804
    Location:282 → 365
    Death_ank2; Death domain of Ankyrin-2
    pfam17809
    Location:124 → 253
    UPA_2; UPA domain

  69. NM_001386174.1 → NP_001373103.1  ankyrin-2 isoform 67

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093617, AC093900
    Consensus CDS
    CCDS93596.1
    UniProtKB/TrEMBL
    H0Y933
    Related
    ENSP00000422888.2, ENST00000506344.6
    Conserved Domains (14) summary
    pfam06390
    Location:3770 → 3884
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:1013 → 1150
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PTZ00449
    Location:1717 → 2161
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03095
    Location:421 → 706
    PHA03095; ankyrin-like protein; Provisional
    PRK14949
    Location:3196 → 3442
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd08804
    Location:3614 → 3697
    Death_ank2; Death domain of Ankyrin-2
    TIGR00600
    Location:3031 → 3565
    rad2; DNA excision repair protein (rad2)
    sd00045
    Location:447 → 478
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:778 → 830
    Ank_4; Ankyrin repeats (many copies)
    pfam15402
    Location:2493 → 2634
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam17809
    Location:1371 → 1500
    UPA_2; UPA domain
    NF033804
    Location:1843 → 2027
    Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
    NF033838
    Location:1549 → 1922
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
    cl39094
    Location:578 → 802
    Ank_2; Ankyrin repeats (3 copies)

  70. NM_001386175.1 → NP_001373104.1  ankyrin-2 isoform 68

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093617, AC093900
    Conserved Domains (15) summary
    pfam06390
    Location:3762 → 3876
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:1005 → 1142
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PTZ00449
    Location:1709 → 2153
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03095
    Location:413 → 698
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:37 → 179
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    PRK14949
    Location:3188 → 3434
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd08804
    Location:3606 → 3689
    Death_ank2; Death domain of Ankyrin-2
    TIGR00600
    Location:3023 → 3557
    rad2; DNA excision repair protein (rad2)
    sd00045
    Location:439 → 470
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:770 → 822
    Ank_4; Ankyrin repeats (many copies)
    pfam15402
    Location:2485 → 2626
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam17809
    Location:1363 → 1492
    UPA_2; UPA domain
    NF033804
    Location:1835 → 2019
    Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
    NF033838
    Location:1541 → 1914
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
    cl39094
    Location:570 → 794
    Ank_2; Ankyrin repeats (3 copies)

  71. NM_001386186.2 → NP_001373115.1  ankyrin-2 isoform 69

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900, AC106864
    Conserved Domains (8) summary
    pfam06390
    Location:1633 → 1790
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:961 → 1098
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:400 → 685
    PHA03095; ankyrin-like protein; Provisional
    cd08804
    Location:1477 → 1560
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:426 → 457
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:757 → 809
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1319 → 1448
    UPA_2; UPA domain
    cl39094
    Location:557 → 781
    Ank_2; Ankyrin repeats (3 copies)

  72. NM_001386187.2 → NP_001373116.1  ankyrin-2 isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093900, AC106864
    Conserved Domains (9) summary
    pfam06390
    Location:1593 → 1750
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:954 → 1058
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA03095
    Location:392 → 677
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:25 → 158
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08804
    Location:1437 → 1520
    Death_ank2; Death domain of Ankyrin-2
    sd00045
    Location:418 → 449
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:749 → 801
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1279 → 1408
    UPA_2; UPA domain
    cl39094
    Location:549 → 773
    Ank_2; Ankyrin repeats (3 copies)

  73. NM_020977.5 → NP_066187.2  ankyrin-2 isoform 2

    See identical proteins and their annotated locations for NP_066187.2

    Status: REVIEWED

    Source sequence(s)
    AC004057, AC093879, AC093900
    Consensus CDS
    CCDS43261.1
    UniProtKB/Swiss-Prot
    Q01484
    Related
    ENSP00000378044.3, ENST00000394537.7
    Conserved Domains (8) summary
    pfam06390
    Location:1638 → 1795
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00218
    Location:966 → 1103
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:529 → 554
    ANK; ankyrin repeats
    cd00204
    Location:227 → 352
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08804
    Location:1482 → 1565
    Death_ank2; Death domain of Ankyrin-2
    pfam12796
    Location:237 → 328
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:37 → 84
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:430 → 461
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    112705622..113383736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    116013980..116692458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001386173.1: Suppressed sequence

    Description
    NM_001386173.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01484.4 GenPept UniProtKB/Swiss-Prot:Q01484

Gene LinkOut

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