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Taok1 TAO kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286993, updated on 5-Sep-2021

Summary

Official Symbol
Taok1provided by RGD
Official Full Name
TAO kinase 1provided by RGD
Primary source
RGD:708455
See related
Ensembl:ENSRNOG00000015692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
protein kinase; involved in regulation of the p38-containing stress-responsive MAP kinase pathway [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 423.5), Adrenal (RPKM 405.0) and 9 other tissues See more
Orthologs
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Genomic context

See Taok1 in Genome Data Viewer
Location:
10q24
Exon count:
24
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62373076..62465295, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62542870..62630341)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene tumor protein p53 inducible protein 13 Neighboring gene abhydrolase domain containing 15 Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial-like Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables alpha-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin V binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress-activated MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase TAO1
Names
thousand and one amino acid protein 1
XP_038941256.1
XP_038941257.1
XP_038941258.1
XP_038941259.1
XP_038941260.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173327.2NP_775449.2  serine/threonine-protein kinase TAO1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000220
    Related
    ENSRNOP00000021368.6, ENSRNOT00000021368.6
    Conserved Domains (2) summary
    COG0419
    Location:442877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    62373076..62465295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085330.1XP_038941258.1  serine/threonine-protein kinase TAO1 isoform X1

    Conserved Domains (2) summary
    COG0419
    Location:442877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
  2. XM_039085328.1XP_038941256.1  serine/threonine-protein kinase TAO1 isoform X1

    Conserved Domains (2) summary
    COG0419
    Location:442877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
  3. XM_039085331.1XP_038941259.1  serine/threonine-protein kinase TAO1 isoform X1

    Conserved Domains (2) summary
    COG0419
    Location:442877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
  4. XM_039085329.1XP_038941257.1  serine/threonine-protein kinase TAO1 isoform X1

    Conserved Domains (2) summary
    COG0419
    Location:442877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
  5. XM_039085332.1XP_038941260.1  serine/threonine-protein kinase TAO1 isoform X1

    Conserved Domains (2) summary
    COG0419
    Location:442877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
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