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Flnb filamin, beta [ Mus musculus (house mouse) ]

Gene ID: 286940, updated on 23-Jun-2021

Summary

Official Symbol
Flnbprovided by MGI
Official Full Name
filamin, betaprovided by MGI
Primary source
MGI:MGI:2446089
See related
Ensembl:ENSMUSG00000025278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fln-b; AL024016
Expression
Ubiquitous expression in colon adult (RPKM 35.6), placenta adult (RPKM 32.0) and 28 other tissues See more
Orthologs
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Genomic context

See Flnb in Genome Data Viewer
Location:
14; 14 A1
Exon count:
46
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14518185..14651852, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (7817921..7951588)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (8650471..8784102)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 1-like 3 Neighboring gene predicted gene 45521 Neighboring gene predicted gene 8396 Neighboring gene predicted gene 10044

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
filamin-B
Names
ABP-280-like protein
actin binding protein 278
actin-binding-like protein
beta-filamin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081427.1NP_001074896.1  filamin-B isoform a

    See identical proteins and their annotated locations for NP_001074896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). This gene lacks full-length transcript support, and therefore the exon combination of this variant is inferred based on tiled partial transcripts and full-length orthologous alignments, e.g., human AF043045.1.
    Source sequence(s)
    AA272439, AC140322, AK050046, BG076906, BP753071, BP753829, BP765788, BU055777, BU703688, BY101832, CA749811, CB290081, CD546916, CD549389, CD555839, CF165547, CF166040, CF536812, CF898917, CJ112968, CN534523, CV558093, DV653022, DV653075
    Consensus CDS
    CCDS70540.1
    UniProtKB/Swiss-Prot
    Q80X90
    Related
    ENSMUSP00000052020.9, ENSMUST00000052678.9
    Conserved Domains (4) summary
    smart00557
    Location:14211514
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:14181508
    Filamin; Filamin/ABP280 repeat
    cl23780
    Location:17181791
    PepSY_TM; PepSY-associated TM region
  2. NM_134080.1NP_598841.1  filamin-B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. This gene lacks full-length transcript support, and therefore the exon combination of this variant is inferred based on tiled partial transcripts and full-length orthologous alignments, e.g., human AB191258.1.
    Source sequence(s)
    AC140322, AK050046, BG076906, BM949278, BM950536, BP753072, BP765788, BU055777, BU703688, BY101832, CA537344, CB194973, CB290081, CD546916, CD549389, CD555839, CF165547, CF166040, CF172628, CF551577, CF736029, CJ112968, CN534523, CV558093
    Conserved Domains (3) summary
    smart00557
    Location:14211514
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:14181508
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    14518185..14651852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518050.2XP_006518113.1  filamin-B isoform X1

    See identical proteins and their annotated locations for XP_006518113.1

    Conserved Domains (2) summary
    smart00557
    Location:14211514
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5069
    Location:14240
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
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