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Dlgap4 DLG associated protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286930, updated on 5-Sep-2025
Official Symbol
Dlgap4provided by RGD
Official Full Name
DLG associated protein 4provided by RGD
Primary source
RGD:708350
See related
Ensembl:ENSRNOG00000020225 AllianceGenome:RGD:708350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dap4; DAP-4; SAPAP4
Summary
Enables protein domain specific binding activity. Predicted to be involved in modification of postsynaptic structure; modulation of chemical synaptic transmission; and regulation of synapse maturation. Located in dendrite and neuronal cell body. Orthologous to human DLGAP4 (DLG associated protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 89.3), Lung (RPKM 58.8) and 9 other tissues See more
Orthologs
human mouse all
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See Dlgap4 in Genome Data Viewer
Location:
3q42
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (165584271..165731868)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145124189..145271791)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152752091..152846118)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101766 Neighboring gene uncharacterized LOC134486192 Neighboring gene uncharacterized LOC103691945 Neighboring gene uncharacterized LOC102551821 Neighboring gene myosin light chain 9

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA. Kindler S, et al. Brain Res Mol Brain Res, 2004 Jul 5. PMID 15207911
  2. Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse. Welch JM, et al. J Comp Neurol, 2004 Apr 19. PMID 15024750
  3. nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP). Kawabe H, et al. J Biol Chem, 1999 Oct 22. PMID 10521485
  4. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. Takeuchi M, et al. J Biol Chem, 1997 May 2. PMID 9115257
  5. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in modification of postsynaptic structure ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
disks large-associated protein 4
Names
PSD-95/SAP90-associated protein-4
PSD-95/SAP90-binding protein 4
SAP90/PSD-95-associated protein 4
SAPAP-4
discs, large homolog-associated protein 4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429777.1 → NP_001416706.1  disks large-associated protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P97839
    UniProtKB/TrEMBL
    A0A8I6ACV4

  2. NM_001429778.1 → NP_001416707.1  disks large-associated protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001429779.1 → NP_001416708.1  disks large-associated protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_001429780.1 → NP_001416709.1  disks large-associated protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  5. NM_001429781.1 → NP_001416710.1  disks large-associated protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  6. NM_173145.3 → NP_775168.2  disks large-associated protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P97839
    UniProtKB/TrEMBL
    A6KIB5, G3V927
    Related
    ENSRNOP00000034166.2, ENSRNOT00000037177.4
    Conserved Domains (1) summary
    pfam03359
    Location:660 → 992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    165584271..165731868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283180.1 → XP_063139250.1  disks large-associated protein 4 isoform X3

  2. XM_063283179.1 → XP_063139249.1  disks large-associated protein 4 isoform X2

  3. XM_039104402.2 → XP_038960330.1  disks large-associated protein 4 isoform X1

    Related
    ENSRNOP00000090954.2, ENSRNOT00000100071.2
    Conserved Domains (1) summary
    pfam03359
    Location:647 → 989
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  4. XM_039104406.2 → XP_038960334.1  disks large-associated protein 4 isoform X7

    Conserved Domains (1) summary
    pfam03359
    Location:17 → 298
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  5. XM_039104408.2 → XP_038960336.1  disks large-associated protein 4 isoform X8

    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  6. XM_063283181.1 → XP_063139251.1  disks large-associated protein 4 isoform X6

  7. XM_039104405.2 → XP_038960333.1  disks large-associated protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A541
    Related
    ENSRNOP00000086332.1, ENSRNOT00000116081.2
    Conserved Domains (1) summary
    pfam03359
    Location:121 → 453
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  8. XM_039104404.2 → XP_038960332.1  disks large-associated protein 4 isoform X4

    Conserved Domains (1) summary
    pfam03359
    Location:130 → 462
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  9. XM_039104407.1 → XP_038960335.1  disks large-associated protein 4 isoform X7

    Conserved Domains (1) summary
    pfam03359
    Location:17 → 298
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  10. XM_039104410.2 → XP_038960338.1  disks large-associated protein 4 isoform X8

    Conserved Domains (1) summary
    pfam03359
    Location:1 → 285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97839.1 GenPept UniProtKB/Swiss-Prot:P97839

Gene LinkOut

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