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Akr1b8 aldo-keto reductase family 1, member B8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286921, updated on 12-Jan-2022

Summary

Official Symbol
Akr1b8provided by RGD
Official Full Name
aldo-keto reductase family 1, member B8provided by RGD
Primary source
RGD:708475
See related
Ensembl:ENSRNOG00000027433
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alditol:NADP+ 1-oxidoreductase activity and estradiol 17-beta-dehydrogenase activity. Predicted to be active in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Adrenal (RPKM 5569.0) and Kidney (RPKM 242.2) See more
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Genomic context

See Akr1b8 in Genome Data Viewer
Location:
4q22
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (62997241..63009815)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (61772064..61784637)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein LOC689277 Neighboring gene aldo-keto reductase family 1 member B Neighboring gene aldo-keto reductase family 1 member B10 Neighboring gene myosin light polypeptide 6-like Neighboring gene aldo-keto reductase family 1, member B7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

  • Homologs of the Akr1b8 gene: The Akr1b8 gene is conserved in human, chimpanzee, Rhesus monkey, cow, mouse, chicken, fruit fly, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, and rice.
  • Orthologs

Clone Names

  • MGC91427

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aldose reductase-related protein 2
Names
aldose reductase-like protein
NP_775159.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173136.1NP_775159.1  aldose reductase-related protein 2

    See identical proteins and their annotated locations for NP_775159.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ277957
    UniProtKB/TrEMBL
    Q91W30
    Related
    ENSRNOP00000068585.2, ENSRNOT00000078996.2
    Conserved Domains (2) summary
    COG0656
    Location:1297
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16289
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    62997241..63009815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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