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Mx2 MX dynamin like GTPase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286918, updated on 7-Apr-2025

Summary

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Official Symbol
Mx2provided by RGD
Official Full Name
MX dynamin like GTPase 2provided by RGD
Primary source
RGD:628821
See related
EnsemblRapid:ENSRNOG00000001963 AllianceGenome:RGD:628821
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mx3
Summary
Predicted to enable GTP binding activity; GTPase activity; and microtubule binding activity. Involved in response to virus. Located in cytoplasm. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Spleen (RPKM 127.4), Lung (RPKM 94.9) and 8 other tissues See more
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Genomic context

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See Mx2 in Genome Data Viewer
Location:
11q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50375101..50399373)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (36905698..36936308)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38035306..38066185)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene MX dynamin like GTPase 1 Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene uncharacterized LOC134480979 Neighboring gene transmembrane serine protease 2 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Antiviral determinants of rat Mx GTPases map to the carboxy-terminal half. Johannes L, et al. J Virol, 1997 Dec. PMID 9371647, Free PMC Article
  2. Activity of rat Mx proteins against a rhabdovirus. Meier E, et al. J Virol, 1990 Dec. PMID 2173790, Free PMC Article
  3. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Rennie ML, et al. Structure, 2014 Oct 7. PMID 25295396
  4. In vitro inhibition of the replication of classical swine fever virus by porcine Mx1 protein. He DN, et al. Antiviral Res, 2014 Apr. PMID 24500530
  5. Inhibition of Dugbe nairovirus replication by human MxA protein. Bridgen A, et al. Virus Res, 2004 Jan. PMID 14687945

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
    Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to type I interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intracellular transport of viral material ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
involved_in response to type I interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon-induced GTP-binding protein Mx2
Names
interferon-induced GTP-binding protein Mx3
myxovirus (influenza virus) resistance 2
myxovirus (influenza virus) resistance 3
myxovirus resistance protein 2
myxovirus resistance protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134350.2 → NP_599177.2  interferon-induced GTP-binding protein Mx2

    See identical proteins and their annotated locations for NP_599177.2

    Status: PROVISIONAL

    Source sequence(s)
    BC099808
    UniProtKB/TrEMBL
    A0A0G2KA85, A0A0G2KAR4, A6IQG6, Q499Q3
    Related
    ENSRNOP00000075302.3, ENSRNOT00000083067.3
    Conserved Domains (3) summary
    cd08771
    Location:66 → 338
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:258 → 544
    Dynamin_M; Dynamin central region
    pfam02212
    Location:569 → 657
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    50375101..50399373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088055.2 → XP_038943983.1  interferon-induced GTP-binding protein Mx2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KA85, A0A0G2KAR4, A6IQG6, Q499Q3
    Conserved Domains (3) summary
    cd08771
    Location:66 → 338
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:258 → 544
    Dynamin_M; Dynamin central region
    pfam02212
    Location:569 → 657
    GED; Dynamin GTPase effector domain

  2. XM_063270316.1 → XP_063126386.1  interferon-induced GTP-binding protein Mx2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KA85, A0A0G2KAR4, A6IQG6, Q499Q3
    Related
    ENSRNOP00000075496.1, ENSRNOT00000087603.3

  3. XM_063270317.1 → XP_063126387.1  interferon-induced GTP-binding protein Mx2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KA85, A0A0G2KAR4, A6IQG6, Q499Q3

  4. XM_063270318.1 → XP_063126388.1  interferon-induced GTP-binding protein Mx2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KA85, A0A0G2KAR4, A6IQG6, Q499Q3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18589.1 GenPept UniProtKB/Swiss-Prot:P18589
P18590.1 GenPept UniProtKB/Swiss-Prot:P18590

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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