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GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens (human) ]

Gene ID: 2869, updated on 17-Jun-2024

Summary

Official Symbol
GRK5provided by HGNC
Official Full Name
G protein-coupled receptor kinase 5provided by HGNC
Primary source
HGNC:HGNC:4544
See related
Ensembl:ENSG00000198873 MIM:600870; AllianceGenome:HGNC:4544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPRK5; FP2025
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 30.9), spleen (RPKM 17.1) and 23 other tissues See more
Orthologs
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Genomic context

See GRK5 in Genome Data Viewer
Location:
10q26.11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119207571..119459745)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (120102994..120355311)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120967083..121219257)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120901959-120902460 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:120924677-120924863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2869 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120937203-120937847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2870 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120942385-120943130 Neighboring gene sideroflexin 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10037 Neighboring gene Sharpr-MPRA regulatory region 12134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2873 Neighboring gene peroxiredoxin 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120981885-120982396 Neighboring gene RNA, 7SL, cytoplasmic 749, pseudogene Neighboring gene GRK5 intronic transcript 1 Neighboring gene Sharpr-MPRA regulatory region 13114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4108 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121000275-121000776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121001445-121002011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121040606-121041106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121048231-121048730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4114 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:121074255-121075454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121076215-121076848 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121076849-121077482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121077483-121078116 Neighboring gene uncharacterized LOC105378511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121100212-121100805 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121100806-121101398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121108919-121109420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121150987-121151487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:121160908-121162107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121164620-121165120 Neighboring gene microRNA 4681 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121203591-121204381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121210069-121210568 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121211884-121212060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121214023-121214544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121225296-121225796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:121239005-121239584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269325-121269826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269827-121270326 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121274963-121275176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121275942-121276524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4125 Neighboring gene NANOG hESC enhancer GRCh37_chr10:121303486-121303994 Neighboring gene regulator of G protein signaling 10 Neighboring gene uncharacterized LOC105378512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121355707-121356705 Neighboring gene TIA1 cytotoxic granule associated RNA binding protein like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ39780

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables beta-adrenergic receptor kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables beta-adrenergic receptor kinase activity TAS
Traceable Author Statement
more info
 
enables phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding TAS
Traceable Author Statement
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G protein-coupled receptor kinase 5
Names
g protein-coupled receptor kinase GRK5
NP_005299.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005308.3NP_005299.1  G protein-coupled receptor kinase 5

    See identical proteins and their annotated locations for NP_005299.1

    Status: REVIEWED

    Source sequence(s)
    AL355273, AL355861, BC018116, BC064506, BQ184611, CN290123, L15388
    Consensus CDS
    CCDS7612.1
    UniProtKB/Swiss-Prot
    D3DRD0, P34947, Q5T059
    UniProtKB/TrEMBL
    B2R7K0
    Related
    ENSP00000376609.2, ENST00000392870.3
    Conserved Domains (3) summary
    cd08752
    Location:53175
    RGS_GRK5; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05632
    Location:183495
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    119207571..119459745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    120102994..120355311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)