Format

Send to:

Choose Destination

GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens (human) ]

Gene ID: 2869, updated on 22-Aug-2020

Summary

Official Symbol
GRK5provided by HGNC
Official Full Name
G protein-coupled receptor kinase 5provided by HGNC
Primary source
HGNC:HGNC:4544
See related
Ensembl:ENSG00000198873 MIM:600870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPRK5; FP2025
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 30.9), spleen (RPKM 17.1) and 23 other tissues See more
Orthologs

Genomic context

See GRK5 in Genome Data Viewer
Location:
10q26.11
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (119207571..119459745)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120967197..121215131)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene sideroflexin 4 Neighboring gene peroxiredoxin 3 Neighboring gene RNA, 7SL, cytoplasmic 749, pseudogene Neighboring gene GRK5 intronic transcript 1 Neighboring gene Sharpr-MPRA regulatory region 9266 Neighboring gene uncharacterized LOC105378511 Neighboring gene microRNA 4681 Neighboring gene regulator of G protein signaling 10 Neighboring gene uncharacterized LOC105378512 Neighboring gene TIA1 cytotoxic granule associated RNA binding protein like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39780

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
beta-adrenergic receptor kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
beta-adrenergic receptor kinase activity TAS
Traceable Author Statement
more info
 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
tachykinin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G protein-coupled receptor kinase 5
Names
g protein-coupled receptor kinase GRK5
NP_005299.1
XP_005269764.1
XP_005269765.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005308.3NP_005299.1  G protein-coupled receptor kinase 5

    See identical proteins and their annotated locations for NP_005299.1

    Status: REVIEWED

    Source sequence(s)
    AL355273, AL355861, BC018116, BC064506, BQ184611, CN290123, L15388
    Consensus CDS
    CCDS7612.1
    UniProtKB/Swiss-Prot
    P34947
    Related
    ENSP00000376609.2, ENST00000392870.3
    Conserved Domains (3) summary
    cd08752
    Location:53175
    RGS_GRK5; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05632
    Location:183495
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    119207571..119459745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269707.2XP_005269764.1  G protein-coupled receptor kinase 5 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:186418
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:53175
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:183465
    PKc_like; Protein Kinases, catalytic domain
  2. XM_005269708.1XP_005269765.1  G protein-coupled receptor kinase 5 isoform X2

    Conserved Domains (3) summary
    cd08752
    Location:21143
    RGS_GRK5; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)
    smart00220
    Location:154416
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05632
    Location:151463
    STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
Support Center