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CD40 CD40 molecule [ Bos taurus (domestic cattle) ]

Gene ID: 286849, updated on 5-Sep-2025
Official Symbol
CD40provided by VGNC
Official Full Name
CD40 moleculeprovided by VGNC
Primary source
VGNC:VGNC:27033
See related
BGD:BT10477; EnsemblRapid:ENSBTAG00070020482
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
TNFRSF5
Orthologs
human mouse all
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See CD40 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (74842418..74853117)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 5 Neighboring gene uncharacterized LOC101904790 Neighboring gene small nucleolar RNA SNORD35 Neighboring gene transfer RNA glycine (anticodon UCC)

Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Cloning, expression and biological function of the bovine CD40 homologue: role in B-lymphocyte growth and differentiation in cattle. Hirano A, et al. Immunology, 1997 Feb. PMID 9135560, Free PMC Article
  2. Clinical disease upregulates expression of CD40 and CD40 ligand on peripheral blood mononuclear cells from cattle naturally infected with Mycobacterium avium subsp. paratuberculosis. Khalifeh MS, et al. Clin Vaccine Immunol, 2013 Aug. PMID 23761659, Free PMC Article
  3. Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages. Sommer S, et al. Vet Immunol Immunopathol, 2009 Mar 15. PMID 19022505
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrated greater CD40 and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.
    Title: Clinical disease upregulates expression of CD40 and CD40 ligand on peripheral blood mononuclear cells from cattle naturally infected with Mycobacterium avium subsp. paratuberculosis.
  2. study investigated the hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis-infected macrophages
    Title: Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages.
Submit: New GeneRIF Correction

Homology

Clone Names

  • MGC157138

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables antigen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in CD40 signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in TRIF-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to protozoan IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response-regulating cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to type II interferon IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of CD40 receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tumor necrosis factor receptor superfamily member 5
Names
B-cell surface antigen CD40
CD40 molecule, TNF receptor superfamily member 5
CD40L receptor
tumor necrosis factor receptor superfamily, member 5

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105611.2 → NP_001099081.1  tumor necrosis factor receptor superfamily member 5 precursor

    See identical proteins and their annotated locations for NP_001099081.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134765
    UniProtKB/Swiss-Prot
    A7YWS9, Q28203
    UniProtKB/TrEMBL
    A0AAF6Z8L4
    Conserved Domains (1) summary
    cd13407
    Location:26 → 186
    TNFRSF5; Tumor necrosis factor receptor superfamily member 5 (TNFRSF5), also known as CD40

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    74842418..74853117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015474118.3 → XP_015329604.2  tumor necrosis factor receptor superfamily member 5 isoform X2

    UniProtKB/TrEMBL
    A0AAA9SP45
    Related
    ENSBTAP00070027698.1, ENSBTAT00070046231.1
    Conserved Domains (1) summary
    cd13407
    Location:22 → 182
    TNFRSF5; Tumor necrosis factor receptor superfamily member 5 (TNFRSF5), also known as CD40

  2. XM_005214504.5 → XP_005214561.2  tumor necrosis factor receptor superfamily member 5 isoform X1

    UniProtKB/TrEMBL
    A0AAF6Z8L4
    Conserved Domains (1) summary
    cd13407
    Location:26 → 186
    TNFRSF5; Tumor necrosis factor receptor superfamily member 5 (TNFRSF5), also known as CD40
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28203.3 GenPept UniProtKB/Swiss-Prot:Q28203

Gene LinkOut

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