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TRIM59 tripartite motif containing 59 [ Homo sapiens (human) ]

Gene ID: 286827, updated on 21-Dec-2025
Official Symbol
TRIM59provided by HGNC
Official Full Name
tripartite motif containing 59provided by HGNC
Primary source
HGNC:HGNC:30834
See related
Ensembl:ENSG00000213186 MIM:616148; AllianceGenome:HGNC:30834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRF1; TSBF1; IFT80L; RNF104; TRIM57
Summary
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in testis (RPKM 4.6), lymph node (RPKM 4.6) and 21 other tissues See more
Orthologs
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See TRIM59 in Genome Data Viewer
Location:
3q25.33
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (160435503..160449786, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (163210117..163224400, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (160153291..160167574, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TRIM59-IFT80 readthrough (NMD candidate) Neighboring gene microRNA 16-2 Neighboring gene microRNA 15b Neighboring gene structural maintenance of chromosomes 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:160149190-160150389 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:160166710-160167230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20758 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:160167750-160168269 Neighboring gene beta-1,3-glucuronyltransferase 3 pseudogene 1 Neighboring gene RNA, U7 small nuclear 136 pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells' killing. Feng X, et al. Invest New Drugs, 2022 Dec. PMID 36306030
  2. Tripartite Motif-Containing Protein 59 (TRIM59) Promotes Epithelial Ovarian Cancer Progression via the Focal Adhesion Kinase(FAK)/AKT/Matrix Metalloproteinase (MMP) Pathway. Zhang P, et al. Med Sci Monit, 2019 May 7. PMID 31062766, Free PMC Article
  3. TRIM59 predicts poor prognosis and promotes pancreatic cancer progression via the PI3K/AKT/mTOR-glycolysis signaling axis. Li R, et al. J Cell Biochem, 2020 Feb. PMID 31693252
  4. Knockdown of tripartite motif 59 (TRIM59) inhibits proliferation in cholangiocarcinoma via the PI3K/AKT/mTOR signalling pathway. Shen H, et al. Gene, 2019 May 25. PMID 30822475
  5. Effects of TRIM59 on RAW264.7 macrophage gene expression and function. Jin Z, et al. Immunobiology, 2021 Jul. PMID 34252840

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of TRIM59 in regulating PPM1A in the pathogenesis of silicosis and the intervention effect of tanshinone IIA.
    Title: Role of TRIM59 in regulating PPM1A in the pathogenesis of silicosis and the intervention effect of tanshinone IIA.
  2. TRIM59 suppresses the brain ischaemia/reperfusion injury and pyroptosis of microglial through mediating the ubiquitination of NLRP3.
    Title: TRIM59 suppresses the brain ischaemia/reperfusion injury and pyroptosis of microglial through mediating the ubiquitination of NLRP3.
  3. A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification.
    Title: A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification.
  4. SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53.
    Title: SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53.
  5. TRIM59 is suppressed by androgen receptor and acts to promote lineage plasticity and treatment-induced neuroendocrine differentiation in prostate cancer.
    Title: TRIM59 is suppressed by androgen receptor and acts to promote lineage plasticity and treatment-induced neuroendocrine differentiation in prostate cancer.
  6. TRIM59 promotes steatosis and ferroptosis in non-alcoholic fatty liver disease via enhancing GPX4 ubiquitination.
    Title: TRIM59 promotes steatosis and ferroptosis in non-alcoholic fatty liver disease via enhancing GPX4 ubiquitination.
  7. TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells' killing.
    Title: TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells' killing.
  8. Regulations of LINC0196/miR-584-5p/miR-34a-5p/TRIM59 on Progression of Pediatric Neuroblastoma.
    Title: Regulations of LINC0196/miR-584-5p/miR-34a-5p/TRIM59 on Progression of Pediatric Neuroblastoma.
  9. The role of Tripartite motif containing 59 (TRIM59) in the proliferation and prognosis of intrahepatic cholangiocarcinoma.
    Title: The role of Tripartite motif containing 59 (TRIM59) in the proliferation and prognosis of intrahepatic cholangiocarcinoma.
  10. Evaluation of tripartite motif 59 and its diagnostic utility in benign bowel diseases and colorectal cancer.
    Title: Evaluation of tripartite motif 59 and its diagnostic utility in benign bowel diseases and colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough TRIM59-IFT80

Readthrough gene: TRIM59-IFT80, Included gene: IFT80

Homology

Clone Names

  • MGC26631, MGC129860, MGC129861

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in host-mediated suppression of symbiont invasion IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
NOT part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
tripartite motif-containing protein 59
Names
RING finger protein 104
tripartite motif-containing 57
tumor suppressor TSBF-1
tumor suppressor TSBF1
NP_775107.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173084.3 → NP_775107.1  tripartite motif-containing protein 59

    See identical proteins and their annotated locations for NP_775107.1

    Status: VALIDATED

    Source sequence(s)
    AC024221, AI215011, AY159379, BC109260
    Consensus CDS
    CCDS3190.1
    UniProtKB/Swiss-Prot
    A8K5G9, D3DNL9, Q8IWR1
    Related
    ENSP00000311219.4, ENST00000309784.9
    Conserved Domains (2) summary
    pfam00643
    Location:96 → 134
    zf-B_box; B-box zinc finger
    cd16763
    Location:5 → 60
    RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    160435503..160449786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    163210117..163224400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWR1.1 GenPept UniProtKB/Swiss-Prot:Q8IWR1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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