Format

Send to:

Choose Destination

TRIM59 tripartite motif containing 59 [ Homo sapiens (human) ]

Gene ID: 286827, updated on 17-Jun-2019

Summary

Official Symbol
TRIM59provided by HGNC
Official Full Name
tripartite motif containing 59provided by HGNC
Primary source
HGNC:HGNC:30834
See related
Ensembl:ENSG00000213186 MIM:616148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRF1; TSBF1; IFT80L; RNF104; TRIM57
Expression
Broad expression in testis (RPKM 4.6), lymph node (RPKM 4.6) and 21 other tissues See more
Orthologs

Genomic context

See TRIM59 in Genome Data Viewer
Location:
3q25.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (160435503..160449786, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (160153291..160167626, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TRIM59-IFT80 protein Neighboring gene microRNA 16-2 Neighboring gene microRNA 15b Neighboring gene structural maintenance of chromosomes 4 Neighboring gene beta-1,3-glucuronyltransferase 3 pseudogene 1 Neighboring gene RNA, U7 small nuclear 136 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TRIM59-IFT80

Readthrough gene: TRIM59-IFT80, Included gene: IFT80

Homology

Clone Names

  • MGC26631, MGC129860, MGC129861

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
NOT intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tripartite motif-containing protein 59
Names
RING finger protein 104
tripartite motif-containing 57
tumor suppressor TSBF-1
tumor suppressor TSBF1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173084.3NP_775107.1  tripartite motif-containing protein 59

    See identical proteins and their annotated locations for NP_775107.1

    Status: VALIDATED

    Source sequence(s)
    AC024221, AI215011, AY159379, BC109260
    Consensus CDS
    CCDS3190.1
    UniProtKB/Swiss-Prot
    Q8IWR1
    Related
    ENSP00000311219.4, ENST00000309784.9
    Conserved Domains (2) summary
    pfam00643
    Location:96134
    zf-B_box; B-box zinc finger
    cd16763
    Location:560
    RING-HC_TRIM59_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 59 (TRIM59) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    160435503..160449786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center