Format

Send to:

Choose Destination

LIN9 lin-9 DREAM MuvB core complex component [ Homo sapiens (human) ]

Gene ID: 286826, updated on 4-Oct-2020

Summary

Official Symbol
LIN9provided by HGNC
Official Full Name
lin-9 DREAM MuvB core complex componentprovided by HGNC
Primary source
HGNC:HGNC:30830
See related
Ensembl:ENSG00000183814 MIM:609375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGS; BARA; TGS1; TGS2; Lin-9; BARPsv
Summary
This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Broad expression in testis (RPKM 3.7), heart (RPKM 2.8) and 24 other tissues See more
Orthologs

Genomic context

See LIN9 in Genome Data Viewer
Location:
1q42.12
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (226231149..226310082, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226418850..226497789, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927247 Neighboring gene ribosomal protein L34 pseudogene 7 Neighboring gene Mix paired-like homeobox Neighboring gene Y-box binding protein 1 pseudogene 9 Neighboring gene signal peptidase complex subunit 3-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
reproduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcriptional repressor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein lin-9 homolog
Names
TUDOR gene similar protein
beta subunit-associated regulator of apoptosis
lin-9 homolog
pRB-associated protein
rb related pathway actor
type I interferon receptor beta chain-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270409.1NP_001257338.1  protein lin-9 homolog isoform 2

    See identical proteins and their annotated locations for NP_001257338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AF190323, AL359742, BC045625, BX284931
    UniProtKB/Swiss-Prot
    Q5TKA1
    Related
    ENSP00000418121.1, ENST00000460719.5
    Conserved Domains (1) summary
    pfam06584
    Location:108212
    DIRP; DIRP
  2. NM_001270410.2NP_001257339.1  protein lin-9 homolog isoform 3

    See identical proteins and their annotated locations for NP_001257339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF190323, AL359742, BC065302, BX284931
    UniProtKB/Swiss-Prot
    Q5TKA1
    UniProtKB/TrEMBL
    Q6P142
    Conserved Domains (1) summary
    pfam06584
    Location:75179
    DIRP; DIRP
  3. NM_001366237.1NP_001353166.1  protein lin-9 homolog isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:143247
    DIRP
  4. NM_001366238.1NP_001353167.1  protein lin-9 homolog isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:142246
    DIRP
  5. NM_001366239.1NP_001353168.1  protein lin-9 homolog isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:143247
    DIRP; DIRP
  6. NM_001366240.1NP_001353169.1  protein lin-9 homolog isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:34138
    DIRP
  7. NM_001366241.1NP_001353170.1  protein lin-9 homolog isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:75179
    DIRP; DIRP
  8. NM_001366245.2NP_001353174.1  protein lin-9 homolog isoform 8

    Status: REVIEWED

    Source sequence(s)
    AF190324, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:127231
    DIRP; DIRP
  9. NM_173083.3NP_775106.2  protein lin-9 homolog isoform 1

    See identical proteins and their annotated locations for NP_775106.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AF190323, AL359742, BC045625
    Consensus CDS
    CCDS1553.1
    UniProtKB/Swiss-Prot
    Q5TKA1
    Related
    ENSP00000329102.5, ENST00000328205.9
    Conserved Domains (1) summary
    pfam06584
    Location:143247
    DIRP; DIRP

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    226231149..226310082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001084.1XP_016856573.1  protein lin-9 homolog isoform X3

  2. XM_024446565.1XP_024302333.1  protein lin-9 homolog isoform X2

    Related
    ENSP00000355773.1, ENST00000366808.5
    Conserved Domains (1) summary
    pfam06584
    Location:200304
    DIRP
  3. XM_006711767.4XP_006711830.1  protein lin-9 homolog isoform X6

    See identical proteins and their annotated locations for XP_006711830.1

    Conserved Domains (1) summary
    pfam06584
    Location:75179
    DIRP; DIRP
  4. XM_011544173.2XP_011542475.1  protein lin-9 homolog isoform X5

    Conserved Domains (1) summary
    pfam06584
    Location:277381
    DIRP; DIRP
Support Center