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LIN9 lin-9 DREAM MuvB core complex component [ Homo sapiens (human) ]

Gene ID: 286826, updated on 4-Dec-2022

Summary

Official Symbol
LIN9provided by HGNC
Official Full Name
lin-9 DREAM MuvB core complex componentprovided by HGNC
Primary source
HGNC:HGNC:30830
See related
Ensembl:ENSG00000183814 MIM:609375; AllianceGenome:HGNC:30830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGS; BARA; TGS1; TGS2; Lin-9; BARPsv
Summary
This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Broad expression in testis (RPKM 3.7), heart (RPKM 2.8) and 24 other tissues See more
Orthologs
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Genomic context

See LIN9 in Genome Data Viewer
Location:
1q42.12
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (226231149..226309767, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (225419172..225497821, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226418850..226497468, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904528 Neighboring gene Sharpr-MPRA regulatory region 4175 Neighboring gene Mix paired-like homeobox Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA U13 Neighboring gene Y-box binding protein 1 pseudogene 9

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in reproduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of transcription repressor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein lin-9 homolog
Names
TUDOR gene similar protein
beta subunit-associated regulator of apoptosis
lin-9 homolog
pRB-associated protein
rb related pathway actor
type I interferon receptor beta chain-associated protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270409.1NP_001257338.1  protein lin-9 homolog isoform 2

    See identical proteins and their annotated locations for NP_001257338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AF190323, AL359742, BC045625, BX284931
    UniProtKB/Swiss-Prot
    Q5TKA1
    Related
    ENSP00000418121.1, ENST00000460719.5
    Conserved Domains (1) summary
    pfam06584
    Location:108212
    DIRP; DIRP
  2. NM_001270410.2NP_001257339.1  protein lin-9 homolog isoform 3

    See identical proteins and their annotated locations for NP_001257339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF190323, AL359742, BC065302, BX284931
    Consensus CDS
    CCDS91164.1
    UniProtKB/Swiss-Prot
    Q5TKA1
    UniProtKB/TrEMBL
    H0Y322, Q6P142
    Related
    ENSP00000355773.2, ENST00000366808.6
    Conserved Domains (1) summary
    pfam06584
    Location:75179
    DIRP; DIRP
  3. NM_001366237.1NP_001353166.1  protein lin-9 homolog isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:143247
    DIRP
  4. NM_001366238.1NP_001353167.1  protein lin-9 homolog isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:142246
    DIRP
  5. NM_001366239.1NP_001353168.1  protein lin-9 homolog isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:143247
    DIRP; DIRP
  6. NM_001366240.1NP_001353169.1  protein lin-9 homolog isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Conserved Domains (1) summary
    pfam06584
    Location:34138
    DIRP
  7. NM_001366241.1NP_001353170.1  protein lin-9 homolog isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359742, BX284931
    Consensus CDS
    CCDS91164.1
    UniProtKB/TrEMBL
    H0Y322
    Conserved Domains (1) summary
    pfam06584
    Location:75179
    DIRP; DIRP
  8. NM_001366245.2NP_001353174.1  protein lin-9 homolog isoform 8

    Status: REVIEWED

    Source sequence(s)
    AF190324, BX284931
    Consensus CDS
    CCDS91165.1
    UniProtKB/Swiss-Prot
    Q7Z3J1
    Related
    ENSP00000505590.1, ENST00000681046.1
    Conserved Domains (1) summary
    pfam06584
    Location:127231
    DIRP; DIRP
  9. NM_173083.3NP_775106.2  protein lin-9 homolog isoform 1

    See identical proteins and their annotated locations for NP_775106.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AF190323, AL359742, BC045625
    Consensus CDS
    CCDS1553.1
    UniProtKB/Swiss-Prot
    Q5TKA1
    Related
    ENSP00000329102.5, ENST00000328205.9
    Conserved Domains (1) summary
    pfam06584
    Location:143247
    DIRP; DIRP

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    226231149..226309767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001084.2XP_016856573.2  protein lin-9 homolog isoform X3

  2. XM_047418546.1XP_047274502.1  protein lin-9 homolog isoform X2

  3. XM_024446565.2XP_024302333.2  protein lin-9 homolog isoform X1

  4. XM_047418553.1XP_047274509.1  protein lin-9 homolog isoform X6

  5. XM_006711767.5XP_006711830.1  protein lin-9 homolog isoform X5

    See identical proteins and their annotated locations for XP_006711830.1

    UniProtKB/TrEMBL
    H0Y322
    Conserved Domains (1) summary
    pfam06584
    Location:75179
    DIRP; DIRP
  6. XM_047418556.1XP_047274512.1  protein lin-9 homolog isoform X7

  7. XM_011544173.3XP_011542475.2  protein lin-9 homolog isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    225419172..225497821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)