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TRAV12-2 T cell receptor alpha variable 12-2 [ Homo sapiens (human) ]

Gene ID: 28673, updated on 13-May-2022

Summary

Official Symbol
TRAV12-2provided by HGNC
Official Full Name
T cell receptor alpha variable 12-2provided by HGNC
Primary source
HGNC:HGNC:12106
See related
Ensembl:ENSG00000211789 IMGT/GENE-DB:TRAV12-2; AllianceGenome:HGNC:12106
Gene type
other
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAV122; TCRAV2S1; TCRAV12S2
Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

See TRAV12-2 in Genome Data Viewer
Location:
14q11.2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21887959..21888502)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (16085593..16086136)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (22356139..22356682)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha locus Neighboring gene T cell receptor alpha variable 8-3 Neighboring gene T cell receptor alpha variable 13-1 Neighboring gene T cell receptor alpha variable 8-4 Neighboring gene T cell receptor alpha variable 8-5 (pseudogene)

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of T cell receptor complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001332.3 

    Range
    266056..266599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    21887959..21888502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    16085593..16086136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)