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FFAR2 free fatty acid receptor 2 [ Homo sapiens (human) ]

Gene ID: 2867, updated on 19-Jun-2019

Summary

Official Symbol
FFAR2provided by HGNC
Official Full Name
free fatty acid receptor 2provided by HGNC
Primary source
HGNC:HGNC:4501
See related
Ensembl:ENSG00000126262 MIM:603823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FFA2R; GPR43
Summary
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]
Expression
Biased expression in appendix (RPKM 7.9), bone marrow (RPKM 5.6) and 11 other tissues See more
Orthologs

Genomic context

See FFAR2 in Genome Data Viewer
Location:
19q13.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35448257..35451767)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35939185..35942669)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1531 Neighboring gene uncharacterized LOC101927522 Neighboring gene RNA, 7SL, cytoplasmic 491, pseudogene Neighboring gene keratinocyte differentiation associated protein Neighboring gene dermokine

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Free fatty acid receptors, organism-specific biosystem (from REACTOME)
    Free fatty acid receptors, organism-specific biosystemFatty acids are the ligands for a small family of G-protein-coupled receptors, the Free Fatty Acid receptors, and an unrelated receptor GPR120. Free fatty acid receptor 1 (FFAR1/GPR40) is activated b...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell surface pattern recognition receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte chemotaxis involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
mucosal immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of acute inflammatory response to non-antigenic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chemokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokine production involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-8 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of acute inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of peptide hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
free fatty acid receptor 2
Names
G-protein coupled receptor 43
fatty acid receptor 2
free fatty acid activated receptor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370087.1NP_001357016.1  free fatty acid receptor 2

    Status: REVIEWED

    Source sequence(s)
    AC002511
  2. NM_005306.3NP_005297.1  free fatty acid receptor 2

    See identical proteins and their annotated locations for NP_005297.1

    Status: REVIEWED

    Source sequence(s)
    AC002511
    Consensus CDS
    CCDS12461.1
    UniProtKB/Swiss-Prot
    O15552
    UniProtKB/TrEMBL
    C6KYL4
    Related
    ENSP00000246549.2, ENST00000246549.2
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35448257..35451767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026711.1XP_016882200.1  free fatty acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    O15552
    UniProtKB/TrEMBL
    C6KYL4
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
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