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FFAR2 free fatty acid receptor 2 [ Homo sapiens (human) ]

Gene ID: 2867, updated on 22-Aug-2021

Summary

Official Symbol
FFAR2provided by HGNC
Official Full Name
free fatty acid receptor 2provided by HGNC
Primary source
HGNC:HGNC:4501
See related
Ensembl:ENSG00000126262 MIM:603823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FFA2R; GPR43
Summary
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]
Expression
Biased expression in appendix (RPKM 7.9), bone marrow (RPKM 5.6) and 11 other tissues See more
Orthologs
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Genomic context

See FFAR2 in Genome Data Viewer
Location:
19q13.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35448257..35451767)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35939159..35942669)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1531 Neighboring gene uncharacterized LOC101927522 Neighboring gene RNA, 7SL, cytoplasmic 491, pseudogene Neighboring gene keratinocyte differentiation associated protein Neighboring gene dermokine

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface pattern recognition receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in leukocyte chemotaxis involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mucosal immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of acute inflammatory response to non-antigenic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of chemokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytokine production involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of acute inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of peptide hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
free fatty acid receptor 2
Names
G-protein coupled receptor 43
fatty acid receptor 2
free fatty acid activated receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370087.1NP_001357016.1  free fatty acid receptor 2

    Status: REVIEWED

    Source sequence(s)
    AC002511
    Related
    ENSP00000473159.1, ENST00000599180.3
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_005306.3NP_005297.1  free fatty acid receptor 2

    See identical proteins and their annotated locations for NP_005297.1

    Status: REVIEWED

    Source sequence(s)
    AC002511
    Consensus CDS
    CCDS12461.1
    UniProtKB/Swiss-Prot
    O15552
    UniProtKB/TrEMBL
    C6KYL4
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35448257..35451767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026711.1XP_016882200.1  free fatty acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    O15552
    UniProtKB/TrEMBL
    C6KYL4
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
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