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TRAV29DV5 T cell receptor alpha variable 29/delta variable 5 [ Homo sapiens (human) ]

Gene ID: 28653, updated on 23-Nov-2021

Summary

Official Symbol
TRAV29DV5provided by HGNC
Official Full Name
T cell receptor alpha variable 29/delta variable 5provided by HGNC
Primary source
HGNC:HGNC:12127
See related
Ensembl:ENSG00000211810 IMGT/GENE-DB:TRAV29/DV5
Gene type
other
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCRA; hADV29S1; TCRAV21S1; TRAV29/DV5
Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

See TRAV29DV5 in Genome Data Viewer
Location:
14q11.2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (22163349..22163870)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (22631245..22631766)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha locus Neighboring gene T cell receptor alpha variable 27 Neighboring gene T cell receptor alpha variable 28 (pseudogene) Neighboring gene T cell receptor alpha variable 30 Neighboring gene T cell receptor alpha variable 31 (pseudogene)

Genomic regions, transcripts, and products

General gene information

Other Names

  • T cell receptor alpha/delta variable 29/DV5
  • T-cell receptor alpha chain V region CTL-L17

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide antigen binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of T cell receptor complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001332.3 

    Range
    541446..541967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    22163349..22163870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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