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FAM133A family with sequence similarity 133 member A [ Homo sapiens (human) ]

Gene ID: 286499, updated on 25-Nov-2025
Official Symbol
FAM133Aprovided by HGNC
Official Full Name
family with sequence similarity 133 member Aprovided by HGNC
Primary source
HGNC:HGNC:26748
See related
Ensembl:ENSG00000179083 AllianceGenome:HGNC:26748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT115
Expression
Biased expression in testis (RPKM 2.8), brain (RPKM 1.0) and 2 other tissues See more
Orthologs
all
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See FAM133A in Genome Data Viewer
Location:
Xq21.32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (93673681..93712265)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (92118892..92157407)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (92929205..92967264)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:92840114-92841313 Neighboring gene ribosomal protein L7 pseudogene 55 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:92882347-92882848 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:92891704-92892690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:92892691-92893676 Neighboring gene nucleosome assembly protein 1 like 3 Neighboring gene USP37 pseudogene 1 Neighboring gene RNA, U6 small nuclear 332, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Sakai H, et al. Clin Transl Med, 2021 Jun. PMID 34185411, Free PMC Article
  2. Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Huber FM, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533407, Free PMC Article
  3. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
  4. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
  5. A protein interaction landscape of breast cancer. Kim M, et al. Science, 2021 Oct. PMID 34591612, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
protein FAM133A
Names
cancer/testis antigen 115

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016400.1 RefSeqGene

    Range
    5194..43253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001171109.2 → NP_001164580.1  protein FAM133A

    See identical proteins and their annotated locations for NP_001164580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL009173, DA414074
    Consensus CDS
    CCDS14466.1
    UniProtKB/Swiss-Prot
    Q8N9E0
    Related
    ENSP00000507109.1, ENST00000683942.1

  2. NM_001171110.2 → NP_001164581.1  protein FAM133A

    See identical proteins and their annotated locations for NP_001164581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL009173, DA188870
    Consensus CDS
    CCDS14466.1
    UniProtKB/Swiss-Prot
    Q8N9E0

  3. NM_001171111.2 → NP_001164582.1  protein FAM133A

    See identical proteins and their annotated locations for NP_001164582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL009173, DB084469
    Consensus CDS
    CCDS14466.1
    UniProtKB/Swiss-Prot
    Q8N9E0
    Related
    ENSP00000318974.4, ENST00000322139.4

  4. NM_173698.3 → NP_775969.1  protein FAM133A

    See identical proteins and their annotated locations for NP_775969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL009173, DA297338
    Consensus CDS
    CCDS14466.1
    UniProtKB/Swiss-Prot
    Q8N9E0
    Related
    ENSP00000362169.1, ENST00000332647.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    93673681..93712265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530926.4 → XP_011529228.1  protein FAM133A isoform X1

    See identical proteins and their annotated locations for XP_011529228.1

    UniProtKB/Swiss-Prot
    Q8N9E0
    Related
    ENSP00000606676.1, ENST00000936617.1

  2. XM_011530927.3 → XP_011529229.1  protein FAM133A isoform X1

    See identical proteins and their annotated locations for XP_011529229.1

    UniProtKB/Swiss-Prot
    Q8N9E0

  3. XM_011530929.2 → XP_011529231.1  protein FAM133A isoform X1

    See identical proteins and their annotated locations for XP_011529231.1

    UniProtKB/Swiss-Prot
    Q8N9E0

  4. XM_017029454.2 → XP_016884943.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  5. XM_017029455.2 → XP_016884944.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  6. XM_011530928.2 → XP_011529230.1  protein FAM133A isoform X1

    See identical proteins and their annotated locations for XP_011529230.1

    UniProtKB/Swiss-Prot
    Q8N9E0
    Related
    ENSP00000606677.1, ENST00000936618.1

  7. XM_011530925.3 → XP_011529227.1  protein FAM133A isoform X1

    See identical proteins and their annotated locations for XP_011529227.1

    UniProtKB/Swiss-Prot
    Q8N9E0
    Related
    ENSP00000537463.1, ENST00000867404.1

  8. XM_017029456.2 → XP_016884945.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  9. XM_006724641.4 → XP_006724704.1  protein FAM133A isoform X1

    See identical proteins and their annotated locations for XP_006724704.1

    UniProtKB/Swiss-Prot
    Q8N9E0

  10. XM_011530931.3 → XP_011529233.1  protein FAM133A isoform X1

    See identical proteins and their annotated locations for XP_011529233.1

    UniProtKB/Swiss-Prot
    Q8N9E0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    92118892..92157407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326903.1 → XP_054182878.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  2. XM_054326902.1 → XP_054182877.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  3. XM_054326910.1 → XP_054182885.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  4. XM_054326909.1 → XP_054182884.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  5. XM_054326906.1 → XP_054182881.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  6. XM_054326908.1 → XP_054182883.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  7. XM_054326904.1 → XP_054182879.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  8. XM_054326907.1 → XP_054182882.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  9. XM_054326905.1 → XP_054182880.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0

  10. XM_054326911.1 → XP_054182886.1  protein FAM133A isoform X1

    UniProtKB/Swiss-Prot
    Q8N9E0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N9E0.1 GenPept UniProtKB/Swiss-Prot:Q8N9E0

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