U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FIRRE firre intergenic repeating RNA element [ Homo sapiens (human) ]

Gene ID: 286467, updated on 5-Mar-2024

Summary

Official Symbol
FIRREprovided by HGNC
Official Full Name
firre intergenic repeating RNA elementprovided by HGNC
Primary source
HGNC:HGNC:49627
See related
Ensembl:ENSG00000213468 MIM:300999; AllianceGenome:HGNC:49627
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC01200
Summary
This gene produces a long RNA containing a repeating sequence. This RNA interacts with heterogeneous nuclear ribonucleoprotein U and coats chromosomes, where it plays an important role in the maintenance of repressive chromatin. This transcript can also act post-transcriptionally to regulate the stability of mRNAs during the innate immune response. [provided by RefSeq, Dec 2017]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FIRRE in Genome Data Viewer
Location:
Xq26.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (131691525..131830643, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (130015761..130154851, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (130825553..130964671, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AF member 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:130798263-130798901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21000 Neighboring gene heparin binding growth factor pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29949 Neighboring gene Sharpr-MPRA regulatory region 5272 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:130851242-130851768 Neighboring gene MPRA-validated peak7427 silencer Neighboring gene NANOG hESC enhancer GRCh37_chrX:130854476-130855009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29953 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29962 Neighboring gene Sharpr-MPRA regulatory region 13451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29964 Neighboring gene Sharpr-MPRA regulatory region 4069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130937096-130937596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130937597-130938097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29965 Neighboring gene Sharpr-MPRA regulatory region 13107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21002 Neighboring gene MAPK regulated corepressor interacting protein 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130960090-130960590 Neighboring gene PNKD pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:131057048-131058247 Neighboring gene RNA, 5S ribosomal pseudogene 514 Neighboring gene Sharpr-MPRA regulatory region 3545 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:131156878-131157424 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:131157425-131157972 Neighboring gene serine/threonine kinase 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • functional intergenic repeating RNA element

Clone Names

  • FLJ40592

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-DNA tethering activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Barr body IDA
Inferred from Direct Assay
more info
PubMed 
located_in X chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in autosome IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026975.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL008629, AL121572, AL365256
    Related
    ENST00000427391.2
  2. NR_152876.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL008629, AL121572, AL365256
    Related
    ENST00000654978.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    131691525..131830643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    130015761..130154851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)