U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ATP11C ATPase phospholipid transporting 11C [ Homo sapiens (human) ]

Gene ID: 286410, updated on 10-Oct-2024

Summary

Official Symbol
ATP11Cprovided by HGNC
Official Full Name
ATPase phospholipid transporting 11Cprovided by HGNC
Primary source
HGNC:HGNC:13554
See related
Ensembl:ENSG00000101974 MIM:300516; AllianceGenome:HGNC:13554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPIG; ATPIQ; HACXL
Summary
Enables phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Predicted to be involved in phospholipid translocation; positive regulation of B cell differentiation; and pre-B cell differentiation. Located in endoplasmic reticulum and plasma membrane. Is integral component of plasma membrane. Implicated in X-linked congenital hemolytic anemia. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 9.4), urinary bladder (RPKM 5.9) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ATP11C in Genome Data Viewer
Location:
Xq27.1
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (139726348..139936903, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (138038281..138248842, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (138808507..139015212, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MCF.2 cell line derived transforming sequence Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21035 Neighboring gene Sharpr-MPRA regulatory region 14619 Neighboring gene brain cytoplasmic RNA 1, pseudogene 1 Neighboring gene RNA, U6atac small nuclear 23, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30005 Neighboring gene microRNA 505 Neighboring gene chromosome X open reading frame 66 Neighboring gene uncharacterized LOC728660

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase-coupled intramembrane lipid transporter activity TAS
Traceable Author Statement
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylethanolamine flippase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine flippase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine floppase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aminophospholipid translocation IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid translocation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid translocation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane HDA PubMed 
part_of phospholipid-translocating ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of phospholipid-translocating ATPase complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipid-transporting ATPase IG
Names
ATPase, class VI, type 11C
P4-ATPase flippase complex alpha subunit ATP11C
probable phospholipid-transporting ATPase IG
NP_001010986.2
NP_001340739.2
NP_001340740.2
NP_001340741.2
NP_775965.3
XP_016884938.1
XP_047297972.1
XP_047297973.1
XP_047297974.1
XP_047297975.1
XP_047297976.1
XP_047297977.1
XP_047297978.1
XP_047297979.1
XP_047297980.1
XP_047297981.1
XP_047297982.1
XP_047297983.1
XP_047297984.1
XP_047297985.1
XP_047297986.1
XP_054182860.1
XP_054182861.1
XP_054182862.1
XP_054182863.1
XP_054182864.1
XP_054182865.1
XP_054182866.1
XP_054182867.1
XP_054182868.1
XP_054182869.1
XP_054182870.1
XP_054182871.1
XP_054182872.1
XP_054182873.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016550.3 RefSeqGene

    Range
    8850..215555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001010986.3NP_001010986.2  phospholipid-transporting ATPase IG isoform b

    Status: VALIDATED

    Source sequence(s)
    AL161777, AL356785
    Consensus CDS
    CCDS35410.1
    UniProtKB/TrEMBL
    A0A067XG54
    Related
    ENSP00000355165.2, ENST00000361648.6
    Conserved Domains (2) summary
    cd02073
    Location:45977
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:8651092
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
  2. NM_001353810.2NP_001340739.2  phospholipid-transporting ATPase IG isoform c

    Status: VALIDATED

    Source sequence(s)
    AL161777, AL356785, AL590077
    UniProtKB/TrEMBL
    A0A067XG54
    Related
    ENSP00000359588.1, ENST00000370557.5
    Conserved Domains (2) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:8621089
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
  3. NM_001353811.2NP_001340740.2  phospholipid-transporting ATPase IG isoform d

    Status: VALIDATED

    Source sequence(s)
    AL161777, AL356785, AL590077
    UniProtKB/TrEMBL
    A0A067XG54
    Conserved Domains (2) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:8621089
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
  4. NM_001353812.2NP_001340741.2  phospholipid-transporting ATPase IG isoform e

    Status: VALIDATED

    Source sequence(s)
    AL161777, AL356785, AL590077
    Consensus CDS
    CCDS94677.1
    UniProtKB/TrEMBL
    A0A067XG54, A0A804HIW2
    Related
    ENSP00000507250.1, ENST00000682941.1
    Conserved Domains (2) summary
    cd02073
    Location:42974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:8621089
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
  5. NM_173694.5NP_775965.3  phospholipid-transporting ATPase IG isoform a

    Status: VALIDATED

    Source sequence(s)
    AL161777, AL356785
    Consensus CDS
    CCDS14668.1
    UniProtKB/Swiss-Prot
    Q5JT69, Q5JT70, Q5JT71, Q5JT72, Q5JT73, Q6ZND5, Q6ZU50, Q6ZUP7, Q70IJ9, Q70IK0, Q8NB49, Q8WX24
    UniProtKB/TrEMBL
    A0A067XG54
    Related
    ENSP00000332756.3, ENST00000327569.7
    Conserved Domains (2) summary
    cd02073
    Location:45977
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:8651092
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    139726348..139936903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442018.1XP_047297974.1  phospholipid-transporting ATPase IG isoform X3

  2. XM_047442024.1XP_047297980.1  phospholipid-transporting ATPase IG isoform X7

  3. XM_047442028.1XP_047297984.1  phospholipid-transporting ATPase IG isoform X11

  4. XM_047442027.1XP_047297983.1  phospholipid-transporting ATPase IG isoform X10

  5. XM_047442016.1XP_047297972.1  phospholipid-transporting ATPase IG isoform X1

  6. XM_047442021.1XP_047297977.1  phospholipid-transporting ATPase IG isoform X4

    UniProtKB/TrEMBL
    A0A804HIW2
  7. XM_017029449.2XP_016884938.1  phospholipid-transporting ATPase IG isoform X12

    Conserved Domains (4) summary
    pfam13246
    Location:203307
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:597824
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl14615
    Location:333409
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl21460
    Location:546575
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  8. XM_047442020.1XP_047297976.1  phospholipid-transporting ATPase IG isoform X4

    UniProtKB/TrEMBL
    A0A804HIW2
  9. XM_047442029.1XP_047297985.1  phospholipid-transporting ATPase IG isoform X12

  10. XM_047442019.1XP_047297975.1  phospholipid-transporting ATPase IG isoform X4

    UniProtKB/TrEMBL
    A0A804HIW2
  11. XM_047442026.1XP_047297982.1  phospholipid-transporting ATPase IG isoform X9

    UniProtKB/TrEMBL
    H7C0E8
    Related
    ENSP00000394573.2, ENST00000422228.2
  12. XM_047442023.1XP_047297979.1  phospholipid-transporting ATPase IG isoform X6

  13. XM_047442025.1XP_047297981.1  phospholipid-transporting ATPase IG isoform X8

  14. XM_047442017.1XP_047297973.1  phospholipid-transporting ATPase IG isoform X2

  15. XM_047442022.1XP_047297978.1  phospholipid-transporting ATPase IG isoform X5

  16. XM_047442030.1XP_047297986.1  phospholipid-transporting ATPase IG isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    138038281..138248842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326887.1XP_054182862.1  phospholipid-transporting ATPase IG isoform X3

  2. XM_054326892.1XP_054182867.1  phospholipid-transporting ATPase IG isoform X7

  3. XM_054326896.1XP_054182871.1  phospholipid-transporting ATPase IG isoform X11

  4. XM_054326891.1XP_054182866.1  phospholipid-transporting ATPase IG isoform X7

  5. XM_054326895.1XP_054182870.1  phospholipid-transporting ATPase IG isoform X10

  6. XM_054326885.1XP_054182860.1  phospholipid-transporting ATPase IG isoform X1

  7. XM_054326889.1XP_054182864.1  phospholipid-transporting ATPase IG isoform X4

  8. XM_054326897.1XP_054182872.1  phospholipid-transporting ATPase IG isoform X12

  9. XM_054326888.1XP_054182863.1  phospholipid-transporting ATPase IG isoform X4

  10. XM_054326894.1XP_054182869.1  phospholipid-transporting ATPase IG isoform X9

  11. XM_054326890.1XP_054182865.1  phospholipid-transporting ATPase IG isoform X6

  12. XM_054326893.1XP_054182868.1  phospholipid-transporting ATPase IG isoform X8

  13. XM_054326886.1XP_054182861.1  phospholipid-transporting ATPase IG isoform X2

  14. XM_054326898.1XP_054182873.1  phospholipid-transporting ATPase IG isoform X13