Format

Send to:

Choose Destination

TUSC1 tumor suppressor candidate 1 [ Homo sapiens (human) ]

Gene ID: 286319, updated on 23-Nov-2021

Summary

Official Symbol
TUSC1provided by HGNC
Official Full Name
tumor suppressor candidate 1provided by HGNC
Primary source
HGNC:HGNC:31010
See related
Ensembl:ENSG00000198680 MIM:610529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG9; TSG-9; CCDC89B
Summary
This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TUSC1 in Genome Data Viewer
Location:
9p21.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (25676969..25678444, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (25676967..25678442, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375996 Neighboring gene uncharacterized LOC105375997 Neighboring gene long intergenic non-protein coding RNA 1241 Neighboring gene family with sequence similarity 71 member B pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of sleep habits and insomnia.
GeneReviews: Not available
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Genome-wide association study identifies candidate genes for male fertility traits in humans.
GeneReviews: Not available
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
GeneReviews: Not available
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
GeneReviews: Not available
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131751

General protein information

Preferred Names
tumor suppressor candidate gene 1 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012031.1 RefSeqGene

    Range
    5001..7470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004125.3NP_001004125.2  tumor suppressor candidate gene 1 protein

    Status: REVIEWED

    Source sequence(s)
    AL590322
    Consensus CDS
    CCDS34999.1
    Related
    ENSP00000350716.4, ENST00000358022.6
    Conserved Domains (1) summary
    cl19252
    Location:61115
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    25676969..25678444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center