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TUSC1 tumor suppressor candidate 1 [ Homo sapiens (human) ]

Gene ID: 286319, updated on 31-Oct-2022

Summary

Official Symbol
TUSC1provided by HGNC
Official Full Name
tumor suppressor candidate 1provided by HGNC
Primary source
HGNC:HGNC:31010
See related
Ensembl:ENSG00000198680 MIM:610529; AllianceGenome:HGNC:31010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG9; TSG-9; CCDC89B
Summary
This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See TUSC1 in Genome Data Viewer
Location:
9p21.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (25676969..25678444, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (25687486..25688961, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (25676967..25678442, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375996 Neighboring gene uncharacterized LOC105375997 Neighboring gene long intergenic non-protein coding RNA 1241 Neighboring gene Sharpr-MPRA regulatory region 6427

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
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EBI GWAS Catalog
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EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
EBI GWAS Catalog
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131751

General protein information

Preferred Names
tumor suppressor candidate gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012031.1 RefSeqGene

    Range
    5415..6890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004125.3NP_001004125.2  tumor suppressor candidate gene 1 protein

    Status: REVIEWED

    Source sequence(s)
    AL590322
    Consensus CDS
    CCDS34999.2
    Related
    ENSP00000350716.4, ENST00000358022.6
    Conserved Domains (1) summary
    cl19252
    Location:61115
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    25676969..25678444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    25687486..25688961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)