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SCAI suppressor of cancer cell invasion [ Homo sapiens (human) ]

Gene ID: 286205, updated on 28-Nov-2021

Summary

Official Symbol
SCAIprovided by HGNC
Official Full Name
suppressor of cancer cell invasionprovided by HGNC
Primary source
HGNC:HGNC:26709
See related
Ensembl:ENSG00000173611 MIM:619222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET40; C9orf126
Summary
This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in brain (RPKM 4.6), lung (RPKM 2.0) and 24 other tissues See more
Orthologs
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Genomic context

See SCAI in Genome Data Viewer
Location:
9q33.3
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (124942608..125143528, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127704887..127905807, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene golgin A1 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene frataxin pseudogene 2 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 2 Neighboring gene protein phosphatase 6 catalytic subunit Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11758, FLJ36664, MGC120525, MGC120526, MGC120528

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein SCAI
Names
suppressor of cancer cell invasion protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016620.1 RefSeqGene

    Range
    5032..205952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144877.3NP_001138349.1  protein SCAI isoform 2

    See identical proteins and their annotated locations for NP_001138349.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL451125, BC104031, BM873972, DB048788
    Consensus CDS
    CCDS48017.1
    UniProtKB/Swiss-Prot
    Q8N9R8
    Related
    ENSP00000336756.6, ENST00000336505.11
    Conserved Domains (1) summary
    pfam12070
    Location:64557
    SCAI; Protein SCAI
  2. NM_173690.5NP_775961.2  protein SCAI isoform 1

    See identical proteins and their annotated locations for NP_775961.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL451125, BC104030, BM873972, DB048788
    Consensus CDS
    CCDS43877.1
    UniProtKB/Swiss-Prot
    Q8N9R8
    Related
    ENSP00000362650.4, ENST00000373549.8
    Conserved Domains (1) summary
    pfam12070
    Location:87580
    SCAI; Protein SCAI

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    124942608..125143528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_929767.1 RNA Sequence

  2. XR_929768.1 RNA Sequence

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