Format

Send to:

Choose Destination

PPP1R42 protein phosphatase 1 regulatory subunit 42 [ Homo sapiens (human) ]

Gene ID: 286187, updated on 1-Jun-2020

Summary

Official Symbol
PPP1R42provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 42provided by HGNC
Primary source
HGNC:HGNC:33732
See related
Ensembl:ENSG00000178125 MIM:617720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dtr; TLLR; TLRR; LRRC67
Summary
The protein encoded by this gene can interact with gamma-tubulin and PP1 phosphatase, a regulator of centrosome separation. The encoded protein is a positive regulator of PP1 phosphatase and thus plays a role in the control of centrosome integrity. [provided by RefSeq, Feb 2017]
Expression
Restricted expression toward testis (RPKM 6.0) See more
Orthologs

Genomic context

See PPP1R42 in Genome Data Viewer
Location:
8q13.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (66964103..67028554, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67876280..67940804, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene small nucleolar RNA host gene 6 Neighboring gene transcription factor 24 Neighboring gene pre-mRNA processing factor 3 pseudogene Neighboring gene uncharacterized LOC105375885 Neighboring gene COP9 signalosome subunit 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein phosphatase 1, regulatory subunit 42 (PPP1R42) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Potential readthrough

Included gene: COPS5

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
dynein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
regulation of phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
manchette ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule organizing center ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 42
Names
leucine rich repeat containing 67
leucine-rich repeat-containing protein 67
testis leucine-rich repeat

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013626.4NP_001013648.1  protein phosphatase 1 regulatory subunit 42 isoform 1

    See identical proteins and their annotated locations for NP_001013648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC110998, BC055413, BU678298
    Consensus CDS
    CCDS34902.1
    UniProtKB/Swiss-Prot
    Q7Z4L9
    Related
    ENSP00000315035.5, ENST00000324682.5
    Conserved Domains (3) summary
    COG4886
    Location:28162
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:3151
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:72114
    LRR_4; Leucine Rich repeats (2 copies)
  2. NM_001348563.1NP_001335492.1  protein phosphatase 1 regulatory subunit 42 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC055413, BX104552
    UniProtKB/Swiss-Prot
    Q7Z4L9
    Related
    ENST00000520633.1
  3. NM_001364910.1NP_001351839.1  protein phosphatase 1 regulatory subunit 42 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC110998
    Related
    ENSP00000429721.1, ENST00000522909.5
    Conserved Domains (2) summary
    sd00033
    Location:3151
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:1104
    LRR_9; Leucine-rich repeat
  4. NM_001364911.2NP_001351840.1  protein phosphatase 1 regulatory subunit 42 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC110998
    Conserved Domains (1) summary
    pfam14580
    Location:61154
    LRR_9; Leucine-rich repeat
  5. NM_001364912.2NP_001351841.1  protein phosphatase 1 regulatory subunit 42 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC110998
    Conserved Domains (2) summary
    sd00033
    Location:3151
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:1104
    LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    66964103..67028554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center