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NKAIN3 sodium/potassium transporting ATPase interacting 3 [ Homo sapiens (human) ]

Gene ID: 286183, updated on 25-Jan-2022

Summary

Official Symbol
NKAIN3provided by HGNC
Official Full Name
sodium/potassium transporting ATPase interacting 3provided by HGNC
Primary source
HGNC:HGNC:26829
See related
Ensembl:ENSG00000185942 MIM:612872; AllianceGenome:HGNC:26829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM77D; UG0898H09; NKAIN3-IT1
Summary
NKAIN3 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NKAIN3 in Genome Data Viewer
Location:
8q12.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (62248854..62999652)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (63161413..63912211)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene asparaginyl-tRNA synthetase 1 pseudogene 2 Neighboring gene serine/threonine-protein kinase PLK1-like Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene SRSF protein kinase 2 pseudogene Neighboring gene X-ray repair cross complementing 6 pseudogene 4 Neighboring gene SRSF protein kinase 2 pseudogene Neighboring gene uncharacterized LOC107986946 Neighboring gene gamma-glutamyl hydrolase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genetic variants associated with disordered eating.
EBI GWAS Catalog
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
EBI GWAS Catalog
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39198, FLJ39630, FLJ45346

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3
Names
NKAIN3 intronic transcript
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3
Na+/K+ transporting ATPase interacting 3
family with sequence similarity 77, member D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304533.3NP_001291462.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 precursor

    See identical proteins and their annotated locations for NP_001291462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AC018861, AC023095, AC087358, AC090577, AC091554, AC120042
    Related
    ENSP00000501908.1, ENST00000623646.3
    Conserved Domains (1) summary
    pfam05640
    Location:10198
    NKAIN; Na,K-Atpase Interacting protein

RNA

  1. NR_130764.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and contains two alternate exons at the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023095, AC120042, AK096949
    Related
    ENST00000523211.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    62248854..62999652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013359.1XP_016868848.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X1

    Related
    ENSP00000501734.1, ENST00000519049.6
  2. XM_017013360.1XP_016868849.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X4

    Conserved Domains (1) summary
    pfam05640
    Location:10177
    NKAIN; Na,K-Atpase Interacting protein
  3. XM_011517511.2XP_011515813.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X2

    Related
    ENSP00000502179.1, ENST00000675749.1
    Conserved Domains (1) summary
    pfam05640
    Location:10177
    NKAIN; Na,K-Atpase Interacting protein
  4. XM_011517512.2XP_011515814.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X3

    Related
    ENSP00000501789.1, ENST00000674732.1
    Conserved Domains (1) summary
    pfam05640
    Location:10157
    NKAIN; Na,K-Atpase Interacting protein
  5. XM_017013361.2XP_016868850.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039769.2: Suppressed sequence

    Description
    NM_001039769.2: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
  2. NM_173688.2: Suppressed sequence

    Description
    NM_173688.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NR_027378.1: Suppressed sequence

    Description
    NR_027378.1: This RefSeq was removed because currently there is insufficient support for the transcript.
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