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ANK1 ankyrin 1 [ Homo sapiens (human) ]

Gene ID: 286, updated on 3-Jan-2019

Summary

Official Symbol
ANK1provided by HGNC
Official Full Name
ankyrin 1provided by HGNC
Primary source
HGNC:HGNC:492
See related
Ensembl:ENSG00000029534 MIM:612641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANK; SPH1; SPH2
Summary
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
Expression
Biased expression in bone marrow (RPKM 23.4) and heart (RPKM 5.1) See more
Orthologs

Genomic context

See ANK1 in Genome Data Viewer
Location:
8p11.21
Exon count:
49
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (41653225..41896762, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41510744..41754280, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723729 Neighboring gene glycerol-3-phosphate acyltransferase 4 Neighboring gene microRNA 486-1 Neighboring gene microRNA 486-2 Neighboring gene NK6 homeobox 3 Neighboring gene Sharpr-MPRA regulatory regions 1042 and 14104 Neighboring gene uncharacterized LOC105379392 Neighboring gene RNA, 7SL, cytoplasmic 149, pseudogene Neighboring gene lysine acetyltransferase 6A Neighboring gene uncharacterized LOC105379393 Neighboring gene ribosomal protein L17 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Spherocytosis type 1
MedGen: C2674218 OMIM: 182900 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
NHGRI GWA Catalog
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
NHGRI GWA Catalog
Genome-wide association study of lung function decline in adults with and without asthma.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Ankyrin binds to the N-terminal region (residues 132-241) of the CA domain of HIV-1 Gag. Ankyrin decreases expression of Gag in HIV-1-infected SupT1 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • CHL1 interactions, organism-specific biosystem (from REACTOME)
    CHL1 interactions, organism-specific biosystemClose homolog of L1 (CHL1) is a member of the L1 family of cell adhesion molecules expressed by subpopulations of neurons and glia in the central and peripheral nervous system. CHL1 like L1 promotes ...
  • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
    COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Interaction between L1 and Ankyrins, organism-specific biosystem (from REACTOME)
    Interaction between L1 and Ankyrins, organism-specific biosystemAnkyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by t...
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Neurofascin interactions, organism-specific biosystem (from REACTOME)
    Neurofascin interactions, organism-specific biosystemNeurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development. There are a range of different isoforms ident...
  • NrCAM interactions, organism-specific biosystem (from REACTOME)
    NrCAM interactions, organism-specific biosystemThe NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytoskeletal adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeletal adaptor activity TAS
Traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding TAS
Traceable Author Statement
more info
PubMed 
ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
spectrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
spectrin binding NAS
Non-traceable Author Statement
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
maintenance of epithelial cell apical/basal polarity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of organelle organization IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
M band IEA
Inferred from Electronic Annotation
more info
 
Z disc IEA
Inferred from Electronic Annotation
more info
 
axolemma IEA
Inferred from Electronic Annotation
more info
 
axon initial segment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
spectrin-associated cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ankyrin-1
Names
ANK-1
ankyrin 1, erythrocytic
ankyrin-R
erythrocyte ankyrin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012820.2 RefSeqGene

    Range
    5001..248538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000037.3NP_000028.3  ankyrin-1 isoform 3

    See identical proteins and their annotated locations for NP_000028.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate segment in the 3' coding region, which includes a stop codon, compared to variant 1. The resulting isoform (3) has a distinct and one aa shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AB209418, AC113133, M28880, N63745, X16609
    Consensus CDS
    CCDS6121.1
    UniProtKB/Swiss-Prot
    P16157
    Related
    ENSP00000289734.7, ENST00000289734.12
    Conserved Domains (10) summary
    smart00218
    Location:9111015
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:601630
    ANK; ankyrin repeats
    COG0666
    Location:341554
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:365490
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14011484
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:337367
    Ank; Ankyrin repeat
    pfam12796
    Location:639730
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1465
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:720774
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:403434
    ANK; ANK repeat [structural motif]
  2. NM_001142445.1NP_001135917.1  ankyrin-1 isoform 10 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks multiple 5' exons, but has an alternate 5' exon which includes an AUG start codon, compared to variant 1. The resulting isoform (10) has a much shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC113133, BC014467, N63745
    Consensus CDS
    CCDS55227.1
    UniProtKB/Swiss-Prot
    P16157
    Related
    ENSP00000430368.1, ENST00000522543.5
  3. NM_001142446.1NP_001135918.1  ankyrin-1 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate upstream 5' exon, which includes an AUG start codon, and has an additional exon in the middle region, but lacks a segment in the 3' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (9) is the longest, which has a distinct N-terminus and an internal additional segment as well as lacks a segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AB209418, AC027702, AC113133, N63745, X16609
    Consensus CDS
    CCDS47849.1
    UniProtKB/Swiss-Prot
    P16157
    Related
    ENSP00000265709.8, ENST00000265709.13
    Conserved Domains (10) summary
    smart00218
    Location:9521056
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:634663
    ANK; ankyrin repeats
    COG0666
    Location:374587
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:398523
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14421525
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:370400
    Ank; Ankyrin repeat
    pfam12796
    Location:672763
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4798
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:753807
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:436467
    ANK; ANK repeat [structural motif]
  4. NM_020475.2NP_065208.2  ankyrin-1 isoform 4

    See identical proteins and their annotated locations for NP_065208.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting isoform (4) is therefore shorter than isoform 1.
    Source sequence(s)
    AA404587, AB209418, AC113133, M28880, N63745, X16609
    UniProtKB/Swiss-Prot
    P16157
    Conserved Domains (10) summary
    smart00218
    Location:9111015
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:601630
    ANK; ankyrin repeats
    COG0666
    Location:341554
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:365490
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14011484
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:337367
    Ank; Ankyrin repeat
    pfam12796
    Location:639730
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1465
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:720774
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:403434
    ANK; ANK repeat [structural motif]
  5. NM_020476.2NP_065209.2  ankyrin-1 isoform 1

    See identical proteins and their annotated locations for NP_065209.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1, also referred to as isoform 2.1.
    Source sequence(s)
    AB209418, AC113133, M28880, N63745, X16609
    Consensus CDS
    CCDS6119.1
    UniProtKB/Swiss-Prot
    P16157
    Related
    ENSP00000339620.4, ENST00000347528.8
    Conserved Domains (10) summary
    smart00218
    Location:9111015
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:601630
    ANK; ankyrin repeats
    COG0666
    Location:341554
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:365490
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14011484
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:337367
    Ank; Ankyrin repeat
    pfam12796
    Location:639730
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1465
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:720774
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:403434
    ANK; ANK repeat [structural motif]
  6. NM_020477.2NP_065210.2  ankyrin-1 isoform 2

    See identical proteins and their annotated locations for NP_065210.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment near to the 3' coding region, compared to variant 1. The resulting isoform (2, also referred to as isoform 2.2) is therefore shorter than isoform 1.
    Source sequence(s)
    AB209418, AC113133, AK126647, M28880, N63745, X16609
    UniProtKB/Swiss-Prot
    P16157
    UniProtKB/TrEMBL
    B3KX39
    Conserved Domains (10) summary
    smart00218
    Location:9111015
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:601630
    ANK; ankyrin repeats
    COG0666
    Location:341554
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:365490
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14011484
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:337367
    Ank; Ankyrin repeat
    pfam12796
    Location:639730
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1465
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:720774
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:403434
    ANK; ANK repeat [structural motif]
  7. NM_020478.4NP_065211.2  ankyrin-1 isoform 5 precursor

    See identical proteins and their annotated locations for NP_065211.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks multiple 5' exons, but has an alternate 5' exon, which includes an AUG start codon, and it also has an alternate segment in the 3' coding region, which includes a stop codon, compared to variant 1. The resulting isoform (5, also referred to as Ank 1.5 and sAnk1) has a much shorter and distinct N-terminus and also has a distinct C-terminus, compared to isoform 1. This small isoform binds to the C-terminus of obscurin, a giant protein surrounding the contractile apparatus in striated muscle, and the binding may be essential for the proper alignment of the network sarcoplasmic reticulum.
    Source sequence(s)
    AC113133, AK223578, BC014467, N63745
    Consensus CDS
    CCDS6122.1
    UniProtKB/Swiss-Prot
    P16157
    Related
    ENSP00000319123.8, ENST00000314214.12
  8. NM_020480.4NP_065213.2  ankyrin-1 isoform 7 precursor

    See identical proteins and their annotated locations for NP_065213.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks multiple 5' exons and an in-frame coding exon in the 3' region, but has an alternate 5' exon which includes an AUG start codon, compared to variant 1. The resulting isoform (7) has a much shorter and distinct N-terminus, and lacks a segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC113133, BC014467, BC117121, N63745
    Consensus CDS
    CCDS6120.1
    UniProtKB/Swiss-Prot
    P16157
    Related
    ENSP00000297744.5, ENST00000348036.8

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    41653225..41896762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273476.4XP_005273533.1  ankyrin-1 isoform X12

    Conserved Domains (10) summary
    smart00218
    Location:9521056
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:634663
    ANK; ankyrin repeats
    COG0666
    Location:374587
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:398523
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14421525
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:370400
    Ank; Ankyrin repeat
    pfam12796
    Location:672763
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4798
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:753807
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:436467
    ANK; ANK repeat [structural motif]
  2. XM_017013324.1XP_016868813.1  ankyrin-1 isoform X11

  3. XM_017013329.1XP_016868818.1  ankyrin-1 isoform X22

  4. XM_011544505.2XP_011542807.1  ankyrin-1 isoform X24

    Conserved Domains (10) summary
    smart00218
    Location:9441048
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:634663
    ANK; ankyrin repeats
    COG0666
    Location:374587
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:398523
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14341517
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:370400
    Ank; Ankyrin repeat
    pfam12796
    Location:672763
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4798
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:753807
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:436467
    ANK; ANK repeat [structural motif]
  5. XM_011544504.2XP_011542806.1  ankyrin-1 isoform X23

    Conserved Domains (10) summary
    smart00218
    Location:9441048
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:634663
    ANK; ankyrin repeats
    COG0666
    Location:374587
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:398523
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14341517
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:370400
    Ank; Ankyrin repeat
    pfam12796
    Location:672763
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4798
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:753807
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:436467
    ANK; ANK repeat [structural motif]
  6. XM_011544502.2XP_011542804.1  ankyrin-1 isoform X18

    Conserved Domains (10) summary
    smart00218
    Location:9441048
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:634663
    ANK; ankyrin repeats
    COG0666
    Location:374587
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:398523
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14341517
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:370400
    Ank; Ankyrin repeat
    pfam12796
    Location:672763
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4798
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:753807
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:436467
    ANK; ANK repeat [structural motif]
  7. XM_011544501.2XP_011542803.1  ankyrin-1 isoform X14

    Conserved Domains (10) summary
    smart00218
    Location:9441048
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:634663
    ANK; ankyrin repeats
    COG0666
    Location:374587
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:398523
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14341517
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:370400
    Ank; Ankyrin repeat
    pfam12796
    Location:672763
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4798
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:753807
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:436467
    ANK; ANK repeat [structural motif]
  8. XM_011544500.2XP_011542802.1  ankyrin-1 isoform X13

    Conserved Domains (10) summary
    smart00218
    Location:9441048
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:634663
    ANK; ankyrin repeats
    COG0666
    Location:374587
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:398523
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14341517
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:370400
    Ank; Ankyrin repeat
    pfam12796
    Location:672763
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4798
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:753807
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:436467
    ANK; ANK repeat [structural motif]
  9. XM_017013322.1XP_016868811.1  ankyrin-1 isoform X9

  10. XM_017013320.2XP_016868809.1  ankyrin-1 isoform X6

  11. XM_011544496.3XP_011542798.1  ankyrin-1 isoform X7

    Conserved Domains (9) summary
    smart00218
    Location:9841088
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:666695
    ANK; ankyrin repeats
    COG0666
    Location:406619
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:430555
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14741557
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:402432
    Ank; Ankyrin repeat
    pfam12796
    Location:704795
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:785839
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:468499
    ANK; ANK repeat [structural motif]
  12. XM_017013319.2XP_016868808.1  ankyrin-1 isoform X3

  13. XM_017013327.2XP_016868816.1  ankyrin-1 isoform X19

  14. XM_011544494.3XP_011542796.1  ankyrin-1 isoform X4

    Conserved Domains (9) summary
    smart00218
    Location:9841088
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:666695
    ANK; ankyrin repeats
    COG0666
    Location:406619
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:430555
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14741557
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:402432
    Ank; Ankyrin repeat
    pfam12796
    Location:704795
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:785839
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:468499
    ANK; ANK repeat [structural motif]
  15. XM_011544490.3XP_011542792.1  ankyrin-1 isoform X1

    Conserved Domains (9) summary
    smart00218
    Location:9841088
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:666695
    ANK; ankyrin repeats
    COG0666
    Location:406619
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:430555
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14741557
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:402432
    Ank; Ankyrin repeat
    pfam12796
    Location:704795
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:785839
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:468499
    ANK; ANK repeat [structural motif]
  16. XM_017013328.2XP_016868817.1  ankyrin-1 isoform X20

  17. XM_011544495.3XP_011542797.1  ankyrin-1 isoform X5

    Conserved Domains (9) summary
    smart00218
    Location:9841088
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:666695
    ANK; ankyrin repeats
    COG0666
    Location:406619
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:430555
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14741557
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:402432
    Ank; Ankyrin repeat
    pfam12796
    Location:704795
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:785839
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:468499
    ANK; ANK repeat [structural motif]
  18. XM_011544491.3XP_011542793.1  ankyrin-1 isoform X2

    Conserved Domains (9) summary
    smart00218
    Location:9841088
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:666695
    ANK; ankyrin repeats
    COG0666
    Location:406619
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:430555
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14741557
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:402432
    Ank; Ankyrin repeat
    pfam12796
    Location:704795
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:785839
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:468499
    ANK; ANK repeat [structural motif]
  19. XM_011544503.3XP_011542805.1  ankyrin-1 isoform X21

    Conserved Domains (9) summary
    smart00218
    Location:9841088
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00248
    Location:666695
    ANK; ankyrin repeats
    COG0666
    Location:406619
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:430555
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14741557
    Death_ank1; Death domain of Ankyrin-1
    pfam00023
    Location:402432
    Ank; Ankyrin repeat
    pfam12796
    Location:704795
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:785839
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:468499
    ANK; ANK repeat [structural motif]
  20. XM_024447128.1XP_024302896.1  ankyrin-1 isoform X16

    Conserved Domains (5) summary
    smart00218
    Location:9191023
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:365490
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08805
    Location:14091492
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:403434
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:305358
    Ank_4; Ankyrin repeats (many copies)
  21. XM_017013323.1XP_016868812.1  ankyrin-1 isoform X10

  22. XM_017013321.1XP_016868810.1  ankyrin-1 isoform X8

  23. XM_017013325.1XP_016868814.1  ankyrin-1 isoform X15

  24. XM_017013326.1XP_016868815.1  ankyrin-1 isoform X17

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020479.2: Suppressed sequence

    Description
    NM_020479.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_020481.2: Suppressed sequence

    Description
    NM_020481.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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