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TCAF2 TRPM8 channel associated factor 2 [ Homo sapiens (human) ]

Gene ID: 285966, updated on 3-Mar-2026
Official Symbol
TCAF2provided by HGNC
Official Full Name
TRPM8 channel associated factor 2provided by HGNC
Primary source
HGNC:HGNC:26878
See related
Ensembl:ENSG00000170379 MIM:616252; AllianceGenome:HGNC:26878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GATD9; GATD9B; FAM115C; FAM139A
Summary
Enables transmembrane transporter binding activity. Involved in negative regulation of anion channel activity; positive regulation of cell migration; and positive regulation of protein targeting to membrane. Located in cell junction and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in esophagus (RPKM 2.3), placenta (RPKM 2.1) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See TCAF2 in Genome Data Viewer
Location:
7q35
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143620974..143730410)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144980488..145010763)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143318067..143427503)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 162, pseudogene Neighboring gene uncharacterized LOC101928466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143300039-143300538 Neighboring gene TRPM8 channel associated factor 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18725 Neighboring gene MPRA-validated peak6807 silencer Neighboring gene TRPM8 channel associated factor 2C Neighboring gene RNA, U6 small nuclear 267, pseudogene Neighboring gene CTAGE family member 6

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. TCAF2 drives glioma cellular migratory/invasion properties through STAT3 signaling. Yun D, et al. Mol Cell Biochem, 2024 Jul. PMID 38019450, Free PMC Article
  2. TCAF2 is associated with the immune microenvironment, promotes pathogenesis, and impairs prognosis in glioma. Li Y, et al. Gene, 2023 Oct 20. PMID 37506986
  3. TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold-Sensing TRPM8 Channel. Li X, et al. Adv Sci (Weinh), 2023 Oct. PMID 37635201, Free PMC Article
  4. Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans. Hsieh P, et al. Nat Commun, 2021 Aug 25. PMID 34433829, Free PMC Article
  5. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. Gkika D, et al. J Cell Biol, 2015 Jan 5. PMID 25559186, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TCAF2 drives glioma cellular migratory/invasion properties through STAT3 signaling.
    Title: TCAF2 drives glioma cellular migratory/invasion properties through STAT3 signaling.
  2. TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold-Sensing TRPM8 Channel.
    Title: TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold-Sensing TRPM8 Channel.
  3. TCAF2 is associated with the immune microenvironment, promotes pathogenesis, and impairs prognosis in glioma.
    Title: TCAF2 is associated with the immune microenvironment, promotes pathogenesis, and impairs prognosis in glioma.
  4. Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans.
    Title: Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans.
  5. Report novel TRP channel-associated factors that modulate TRPM8 activity.
    Title: TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ40722, FLJ78808, MGC142090

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of anion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
TRPM8 channel-associated factor 2
Names
TRP channel-associated factor 2
family with sequence similarity 115, member C
family with sequence similarity 139, member A
protein FAM115C
NP_001352356.1

Length

  • 259

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130026.3 → NP_001123498.2  TRPM8 channel-associated factor 2 isoform B

    See identical proteins and their annotated locations for NP_001123498.2

    Status: VALIDATED

    Source sequence(s)
    AC106862, AK296318, CN479606, DC402602
    Consensus CDS
    CCDS47735.2
    UniProtKB/TrEMBL
    A0AAG2UWM7
    Related
    ENSP00000441099.2, ENST00000425618.3
    Conserved Domains (1) summary
    pfam13402
    Location:440 → 785
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like

  2. NM_001363538.2 → NP_001350467.1  TRPM8 channel-associated factor 2 isoform C

    Status: VALIDATED

    Source sequence(s)
    AC073264, AC106862
    Consensus CDS
    CCDS87559.1
    UniProtKB/Swiss-Prot
    A6NFQ2, B4DK02, Q14D25, Q17RQ4, Q8IWQ0, Q8NF84
    UniProtKB/TrEMBL
    A0AAG2UWC6
    Related
    ENSP00000506869.1, ENST00000684770.1
    Conserved Domains (1) summary
    pfam13402
    Location:520 → 889
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like

  3. NM_001365427.2 → NP_001352356.1  TRPM8 channel-associated factor 2 isoform D

    Status: VALIDATED

    Source sequence(s)
    AC073264, AK315909
    UniProtKB/TrEMBL
    B7Z9E4

  4. NM_001365428.1 → NP_001352357.1  TRPM8 channel-associated factor 2 isoform E

    Status: VALIDATED

    Source sequence(s)
    AK098041, AL832734, BC113530
    Consensus CDS
    CCDS94223.1
    UniProtKB/TrEMBL
    A0AAG2UY34, H0YC74, Q8N1I1
    Related
    ENSP00000431079.2, ENST00000518791.6
    Conserved Domains (1) summary
    pfam13402
    Location:239 → 554
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like

  5. NM_001365429.2 → NP_001352358.2  TRPM8 channel-associated factor 2 isoform A

    Status: VALIDATED

    Source sequence(s)
    AC073264, AC106862
    UniProtKB/TrEMBL
    A0AAG2UWF1
    Related
    ENSP00000412724.2, ENST00000444908.7

  6. NM_001438662.2 → NP_001425591.2  TRPM8 channel-associated factor 2 isoform C

    Status: VALIDATED

    Source sequence(s)
    AC073264, AC106862
    UniProtKB/Swiss-Prot
    A6NFQ2, B4DK02, Q14D25, Q17RQ4, Q8IWQ0, Q8NF84
    UniProtKB/TrEMBL
    A0AAG2UWC6
    Related
    ENSP00000404265.2, ENST00000441159.7

  7. NM_001438663.2 → NP_001425592.2  TRPM8 channel-associated factor 2 isoform C

    Status: VALIDATED

    Source sequence(s)
    AC073264, AC106862
    UniProtKB/Swiss-Prot
    A6NFQ2, B4DK02, Q14D25, Q17RQ4, Q8IWQ0, Q8NF84
    UniProtKB/TrEMBL
    A0AAG2UWC6

  8. NM_001438664.1 → NP_001425593.1  TRPM8 channel-associated factor 2 isoform G

    Status: VALIDATED

    Source sequence(s)
    AC073264, AC106862
    UniProtKB/TrEMBL
    A0A1B0GVM2

  9. NM_001438665.1 → NP_001425594.1  TRPM8 channel-associated factor 2 isoform G

    Status: VALIDATED

    Source sequence(s)
    AC073264, AC106862
    UniProtKB/TrEMBL
    A0A1B0GVM2

  10. NM_001438666.1 → NP_001425595.1  TRPM8 channel-associated factor 2 isoform H

    Status: VALIDATED

    Source sequence(s)
    AC073264, AC106862
    UniProtKB/TrEMBL
    A0A1B0GVM2

  11. NM_173678.3 → NP_775949.2  TRPM8 channel-associated factor 2 isoform A

    See identical proteins and their annotated locations for NP_775949.2

    Status: VALIDATED

    Source sequence(s)
    AC106862, AL832734, BC113530
    Consensus CDS
    CCDS34769.1
    UniProtKB/TrEMBL
    A0AAG2UWF1
    Related
    ENSP00000495809.1, ENST00000643242.1
    Conserved Domains (1) summary
    pfam13402
    Location:520 → 835
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    143620974..143730410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420219.1 → XP_047276175.1  TRPM8 channel-associated factor 2 isoform X3

  2. XM_047420218.1 → XP_047276174.1  TRPM8 channel-associated factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GVM2

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654714.1 Reference GRCh38.p14 PATCHES

    Range
    244454..274729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    144980488..145010763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001130025.1: Suppressed sequence

    Description
    NM_001130025.1: This RefSeq has been removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NFQ2.2 GenPept UniProtKB/Swiss-Prot:A6NFQ2

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