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GPR35 G protein-coupled receptor 35 [ Homo sapiens (human) ]

Gene ID: 2859, updated on 22-Sep-2022

Summary

Official Symbol
GPR35provided by HGNC
Official Full Name
G protein-coupled receptor 35provided by HGNC
Primary source
HGNC:HGNC:4492
See related
Ensembl:ENSG00000178623 MIM:602646; AllianceGenome:HGNC:4492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables C-X-C chemokine receptor activity. Involved in several processes, including chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum (RPKM 17.7), small intestine (RPKM 16.7) and 7 other tissues See more
Orthologs
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Genomic context

See GPR35 in Genome Data Viewer
Location:
2q37.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240605430..240633159)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241099521..241129422)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241544847..241572576)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5965 Neighboring gene CAPN10 divergent transcript Neighboring gene calpain 10 Neighboring gene Sharpr-MPRA regulatory region 3769 Neighboring gene uncharacterized LOC124908016 Neighboring gene galactose-3-O-sulfotransferase 1 pseudogene Neighboring gene aquaporin 12B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CAPN10

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-X-C chemokine receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G-protein coupled receptor 35
Names
KYNA receptor
kynurenic acid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195381.3NP_001182310.1  G-protein coupled receptor 35 isoform b

    See identical proteins and their annotated locations for NP_001182310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Variants 2-4 all encode the same isoform (b).
    Source sequence(s)
    AC124862
    Consensus CDS
    CCDS56174.1
    UniProtKB/Swiss-Prot
    Q9HC97
    Conserved Domains (1) summary
    cd15164
    Location:74318
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001195382.3NP_001182311.1  G-protein coupled receptor 35 isoform b

    See identical proteins and their annotated locations for NP_001182311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Variants 2-4 all encode the same isoform (b).
    Source sequence(s)
    AC124862
    Consensus CDS
    CCDS56174.1
    UniProtKB/Swiss-Prot
    Q9HC97
    UniProtKB/TrEMBL
    A8K2J1
    Related
    ENSP00000411788.2, ENST00000430267.2
    Conserved Domains (1) summary
    cd15164
    Location:74318
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001394730.1NP_001381659.1  G-protein coupled receptor 35 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124862
    Conserved Domains (1) summary
    cd15164
    Location:74318
    7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_005301.5NP_005292.2  G-protein coupled receptor 35 isoform a

    See identical proteins and their annotated locations for NP_005292.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a, also known as GPR35a).
    Source sequence(s)
    AC124862
    Consensus CDS
    CCDS2541.1
    UniProtKB/Swiss-Prot
    Q86UH4, Q9HC97
    UniProtKB/TrEMBL
    A8K2J1, B2RA17
    Related
    ENSP00000384263.1, ENST00000407714.2
    Conserved Domains (1) summary
    pfam00001
    Location:43276
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    240605430..240633159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    241099521..241129422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)