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CNPY1 canopy FGF signaling regulator 1 [ Homo sapiens (human) ]

Gene ID: 285888, updated on 26-Oct-2022

Summary

Official Symbol
CNPY1provided by HGNC
Official Full Name
canopy FGF signaling regulator 1provided by HGNC
Primary source
HGNC:HGNC:27786
See related
Ensembl:ENSG00000146910 MIM:612493; AllianceGenome:HGNC:27786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Cnpy1 is expressed in the midbrain-hindbrain (MHB) boundary in zebrafish, binds FGFR1 (MIM 136350), and plays a role in FGF signaling (Hirate and Okamoto, 2006 [PubMed 16488878]).[supplied by OMIM, Dec 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CNPY1 in Genome Data Viewer
Location:
7q36.3
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (155501129..155546559, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (156681736..156727153, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (155293824..155339254, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1418 Neighboring gene engrailed homeobox 2 Neighboring gene Sharpr-MPRA regulatory region 10004 Neighboring gene RBM33 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC125606

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein canopy homolog 1
Names
canopy 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103176.2NP_001096646.1  protein canopy homolog 1 isoform b

    See identical proteins and their annotated locations for NP_001096646.1

    Status: VALIDATED

    Source sequence(s)
    AC008060, AC009403
    Consensus CDS
    CCDS43684.1
    UniProtKB/Swiss-Prot
    A6NGX3, Q3B7I2
    Related
    ENSP00000317439.5, ENST00000321736.5
    Conserved Domains (1) summary
    pfam11938
    Location:177
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  2. NM_001369814.1NP_001356743.1  protein canopy homolog 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC008060, AC009403
    Consensus CDS
    CCDS43684.1
    UniProtKB/Swiss-Prot
    A6NGX3
    Conserved Domains (1) summary
    pfam11938
    Location:177
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  3. NM_001369815.1NP_001356744.1  protein canopy homolog 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC008060
    Consensus CDS
    CCDS43684.1
    UniProtKB/Swiss-Prot
    A6NGX3
    Conserved Domains (1) summary
    pfam11938
    Location:177
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  4. NM_001369816.1NP_001356745.1  protein canopy homolog 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC008060
    Consensus CDS
    CCDS43684.1
    UniProtKB/Swiss-Prot
    A6NGX3
    Conserved Domains (1) summary
    pfam11938
    Location:177
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  5. NM_001369818.2NP_001356747.2  protein canopy homolog 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC008060
    Consensus CDS
    CCDS43684.1
    UniProtKB/Swiss-Prot
    A6NGX3
    Conserved Domains (1) summary
    pfam11938
    Location:177
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  6. NM_001369820.1NP_001356749.1  protein canopy homolog 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC008060
    Consensus CDS
    CCDS43684.1
    UniProtKB/Swiss-Prot
    A6NGX3
    Conserved Domains (1) summary
    pfam11938
    Location:177
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  7. NM_001369821.1NP_001356750.1  protein canopy homolog 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC008060
    Consensus CDS
    CCDS43684.1
    UniProtKB/Swiss-Prot
    A6NGX3
    Conserved Domains (1) summary
    pfam11938
    Location:177
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  8. NM_001393663.1NP_001380592.1  protein canopy homolog 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) encodes the longer isoform (a).
    Source sequence(s)
    AC008060, AC009403
    Consensus CDS
    CCDS94241.1
    UniProtKB/TrEMBL
    A0A1B0GUD4
    Related
    ENSP00000490477.3, ENST00000636446.2

RNA

  1. NR_163157.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060, AC009403
  2. NR_163158.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060, AC009403
  3. NR_163159.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060
  4. NR_163160.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060
    Related
    ENST00000682997.2
  5. NR_163161.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060
  6. NR_163162.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060
  7. NR_163163.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060
  8. NR_163164.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060
  9. NR_163165.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060
  10. NR_163166.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060
  11. NR_163167.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008060

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    155501129..155546559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    156681736..156727153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001369813.1: Suppressed sequence

    Description
    NM_001369813.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.