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TREML4 triggering receptor expressed on myeloid cells like 4 [ Homo sapiens (human) ]

Gene ID: 285852, updated on 13-Nov-2022

Summary

Official Symbol
TREML4provided by HGNC
Official Full Name
triggering receptor expressed on myeloid cells like 4provided by HGNC
Primary source
HGNC:HGNC:30807
See related
Ensembl:ENSG00000188056 MIM:614664; AllianceGenome:HGNC:30807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLT4; TLT-4
Summary
Predicted to enable signaling receptor activity. Involved in positive regulation of toll-like receptor 7 signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface. Predicted to colocalize with endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TREML4 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41228349..41238882)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41057643..41068182)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41196087..41206620)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells like 3, pseudogene Neighboring gene uncharacterized LOC105375055 Neighboring gene RNA, 5S ribosomal pseudogene 207 Neighboring gene triggering receptor expressed on myeloid cells like 5, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC126829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
trem-like transcript 4 protein
Names
TREM like transcript 4
triggering receptor expressed on myeloid cells-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198153.3NP_937796.1  trem-like transcript 4 protein precursor

    See identical proteins and their annotated locations for NP_937796.1

    Status: VALIDATED

    Source sequence(s)
    AL391903, AY358271
    Consensus CDS
    CCDS34446.1
    UniProtKB/Swiss-Prot
    B7ZL92, Q6UXN2
    Related
    ENSP00000342570.2, ENST00000341495.7
    Conserved Domains (2) summary
    cd05716
    Location:27121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25129
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    41228349..41238882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    41057643..41068182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)