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CAGE1 cancer antigen 1 [ Homo sapiens (human) ]

Gene ID: 285782, updated on 1-Mar-2024

Summary

Official Symbol
CAGE1provided by HGNC
Official Full Name
cancer antigen 1provided by HGNC
Primary source
HGNC:HGNC:21622
See related
Ensembl:ENSG00000164304 MIM:608304; AllianceGenome:HGNC:21622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT3; CT95; CTAG3; bA69L16.7
Expression
Restricted expression toward testis (RPKM 5.0) See more
Orthologs
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Genomic context

See CAGE1 in Genome Data Viewer
Location:
6p24.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (7326659..7389742, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (7195720..7258781, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (7326892..7389975, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16885 Neighboring gene Sharpr-MPRA regulatory region 12169 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:7119221-7119796 Neighboring gene NANOG hESC enhancer GRCh37_chr6:7124594-7125112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:7140608-7141135 Neighboring gene ras responsive element binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:7145752-7146422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23938 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:7151030-7151195 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:7156680-7157346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:7160729-7161690 Neighboring gene VISTA enhancer hs2061 Neighboring gene Sharpr-MPRA regulatory region 4659 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:7169201-7169702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:7169703-7170202 Neighboring gene skeletal muscle cis-regulatory module in RREB1 intron Neighboring gene Sharpr-MPRA regulatory region 2698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23941 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:7258615-7259114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:7261311-7262102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:7262103-7262894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:7267569-7268070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:7273665-7274166 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_94357 Neighboring gene MPRA-validated peak5642 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:7312596-7313464 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:7313465-7314331 Neighboring gene signal sequence receptor subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16890 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:7342644-7342806 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:7346982-7347886 Neighboring gene ACCSL pseudogene 1 Neighboring gene ribosomal protein S3 pseudogene 4 Neighboring gene MPRA-validated peak5644 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23948 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:7389927-7390713 Neighboring gene NANOG hESC enhancer GRCh37_chr6:7413126-7413896 Neighboring gene RIO kinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:7425815-7426316 Neighboring gene uncharacterized LOC102724234

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
cancer-associated gene 1 protein
Names
cancer/testis antigen 3
cancer/testis antigen 95
cancer/testis antigen gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170692.2NP_001164163.1  cancer-associated gene 1 protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL139095
    Consensus CDS
    CCDS54965.1
    UniProtKB/TrEMBL
    E7EUJ7
    Related
    ENSP00000425493.1, ENST00000502583.6
    Conserved Domains (4) summary
    COG0419
    Location:307839
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam15066
    Location:30517
    CAGE1; Cancer-associated gene protein 1 family
    cd16269
    Location:512521
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:350541
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001170693.2NP_001164164.1  cancer-associated gene 1 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region and uses an alternate exon in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) lacks an internal segment and has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF414185, AK097760, AL139095, BC026194
    Consensus CDS
    CCDS54964.1
    UniProtKB/Swiss-Prot
    D6RCT9, Q5TAM0, Q86TM4, Q8N7R5, Q8TC20
    Related
    ENSP00000338107.4, ENST00000338150.8
    Conserved Domains (3) summary
    pfam15066
    Location:30517
    CAGE1; Cancer-associated gene protein 1 family
    cd16269
    Location:512521
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:350541
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_205864.3NP_995586.1  cancer-associated gene 1 protein isoform 3

    See identical proteins and their annotated locations for NP_995586.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF414185, AL139095, BC033545
    Consensus CDS
    CCDS47367.1
    UniProtKB/Swiss-Prot
    D6RCT9, Q5TAM0, Q86TM4, Q8N7R5, Q8TC20
    Related
    ENSP00000296742.7, ENST00000296742.11
    Conserved Domains (3) summary
    pfam15066
    Location:2381
    CAGE1; Cancer-associated gene protein 1 family
    cd16269
    Location:376385
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:214405
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    7326659..7389742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    7195720..7258781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175745.3: Suppressed sequence

    Description
    NM_175745.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.