Format

Send to:

Choose Destination

CEP57L1 centrosomal protein 57 like 1 [ Homo sapiens (human) ]

Gene ID: 285753, updated on 24-Nov-2020

Summary

Official Symbol
CEP57L1provided by HGNC
Official Full Name
centrosomal protein 57 like 1provided by HGNC
Primary source
HGNC:HGNC:21561
See related
Ensembl:ENSG00000183137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
cep57R; C6orf182; bA487F23.2
Expression
Ubiquitous expression in testis (RPKM 2.6), brain (RPKM 1.5) and 25 other tissues See more
Orthologs

Genomic context

See CEP57L1 in Genome Data Viewer
Location:
6q21
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (109095163..109174418)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (109416329..109485115)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 2 Neighboring gene ARMC2 antisense RNA 1 Neighboring gene sestrin 1 Neighboring gene RNA, U6 small nuclear 653, pseudogene Neighboring gene coiled-coil domain containing 162, pseudogene Neighboring gene patched domain containing 3 pseudogene 3 Neighboring gene RNY3 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC21731, MGC70837

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
centrosomal protein CEP57L1
Names
centrosomal protein 57kDa-like 1
centrosomal protein 57kDa-like protein 1
centrosomal protein of 57 kDa-related protein
cep57-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083535.3NP_001077004.1  centrosomal protein CEP57L1 isoform 1

    See identical proteins and their annotated locations for NP_001077004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (1).
    Source sequence(s)
    AL355305
    Consensus CDS
    CCDS5071.1
    UniProtKB/Swiss-Prot
    Q8IYX8
    Conserved Domains (2) summary
    pfam06657
    Location:311384
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  2. NM_001271852.3NP_001258781.1  centrosomal protein CEP57L1 isoform 1

    See identical proteins and their annotated locations for NP_001258781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (1).
    Source sequence(s)
    AL355305
    Consensus CDS
    CCDS5071.1
    UniProtKB/Swiss-Prot
    Q8IYX8
    Related
    ENSP00000427844.1, ENST00000517392.5
    Conserved Domains (2) summary
    pfam06657
    Location:311384
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  3. NM_001271853.3NP_001258782.1  centrosomal protein CEP57L1 isoform 2

    See identical proteins and their annotated locations for NP_001258782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL355305
    Consensus CDS
    CCDS64491.1
    UniProtKB/Swiss-Prot
    Q8IYX8
    Related
    ENSP00000357964.2, ENST00000368968.6
    Conserved Domains (2) summary
    pfam06657
    Location:311384
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  4. NM_001350652.2NP_001337581.1  centrosomal protein CEP57L1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, 3, and 6, encodes isoform 1.
    Source sequence(s)
    AL355305
    Consensus CDS
    CCDS5071.1
    Conserved Domains (2) summary
    pfam06657
    Location:311384
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  5. NM_001350653.2NP_001337582.1  centrosomal protein CEP57L1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, 3, and 5, encodes isoform 1.
    Source sequence(s)
    AL355305
    Consensus CDS
    CCDS5071.1
    Conserved Domains (2) summary
    pfam06657
    Location:311384
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  6. NM_001350654.2NP_001337583.1  centrosomal protein CEP57L1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 8, 9, 10, and 11, encodes isoform 3.
    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:328401
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  7. NM_001350655.2NP_001337584.1  centrosomal protein CEP57L1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 7, 9, 10, and 11, encodes isoform 3.
    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:328401
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  8. NM_001350656.2NP_001337585.1  centrosomal protein CEP57L1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 7, 8, 10, and 11, encodes isoform 3.
    Source sequence(s)
    AL355305
    Consensus CDS
    CCDS87427.1
    Related
    ENSP00000357966.2, ENST00000368970.6
    Conserved Domains (2) summary
    pfam06657
    Location:328401
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  9. NM_001350657.2NP_001337586.1  centrosomal protein CEP57L1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 7, 8, 9, and 11, encodes isoform 3.
    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:328401
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  10. NM_001350658.2NP_001337587.1  centrosomal protein CEP57L1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) represents the longest transcript and encodes the longest isoform (3). Variants 7-11 all encode the same isoform (3).
    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:328401
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  11. NM_001350659.2NP_001337588.1  centrosomal protein CEP57L1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:312385
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54215
    Cep57_CLD; Centrosome localization domain of Cep57
  12. NM_001350660.2NP_001337589.1  centrosomal protein CEP57L1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 14, encodes isoform 5.
    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:190263
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:193
    Cep57_CLD; Centrosome localization domain of Cep57
  13. NM_001350661.2NP_001337590.1  centrosomal protein CEP57L1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variant 13, encodes isoform 5.
    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:190263
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:193
    Cep57_CLD; Centrosome localization domain of Cep57
  14. NM_001350662.2NP_001337591.1  centrosomal protein CEP57L1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 16 and 17, encodes isoform 6.
    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:173246
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:193
    Cep57_CLD; Centrosome localization domain of Cep57
  15. NM_001350663.2NP_001337592.1  centrosomal protein CEP57L1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 15 and 17, encodes isoform 6.
    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:173246
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:193
    Cep57_CLD; Centrosome localization domain of Cep57
  16. NM_001350664.2NP_001337593.1  centrosomal protein CEP57L1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 15 and 16, encodes isoform 6.
    Source sequence(s)
    AL355305
    Conserved Domains (2) summary
    pfam06657
    Location:173246
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:193
    Cep57_CLD; Centrosome localization domain of Cep57
  17. NM_001350665.2NP_001337594.1  centrosomal protein CEP57L1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL355305
    Consensus CDS
    CCDS87428.1
    Related
    ENSP00000383936.2, ENST00000407272.5
    Conserved Domains (1) summary
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57
  18. NM_001350666.2NP_001337595.1  centrosomal protein CEP57L1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL355305
    Consensus CDS
    CCDS87429.1
    Related
    ENSP00000430558.1, ENST00000521277.5
    Conserved Domains (1) summary
    pfam14073
    Location:54215
    Cep57_CLD; Centrosome localization domain of Cep57
  19. NM_173830.5NP_776191.1  centrosomal protein CEP57L1 isoform 1

    See identical proteins and their annotated locations for NP_776191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (1).
    Source sequence(s)
    AL355305
    Consensus CDS
    CCDS5071.1
    UniProtKB/Swiss-Prot
    Q8IYX8
    Related
    ENSP00000352841.3, ENST00000359793.7
    Conserved Domains (2) summary
    pfam06657
    Location:311384
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:54231
    Cep57_CLD; Centrosome localization domain of Cep57

RNA

  1. NR_146888.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355305
  2. NR_146889.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355305

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    109095163..109174418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center