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RELL2 RELT like 2 [ Homo sapiens (human) ]

Gene ID: 285613, updated on 23-Nov-2021

Summary

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Official Symbol
RELL2provided by HGNC
Official Full Name
RELT like 2provided by HGNC
Primary source
HGNC:HGNC:26902
See related
Ensembl:ENSG00000164620 MIM:611213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5orf16
Expression
Ubiquitous expression in spleen (RPKM 5.1), lymph node (RPKM 4.7) and 24 other tissues See more
Orthologs
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Genomic context

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See RELL2 in Genome Data Viewer
Location:
5q31.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (141636961..141641077)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141016564..141020631)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene diaphanous related formin 1 Neighboring gene RPS27A pseudogene 10 Neighboring gene histone deacetylase 3 Neighboring gene FCH and double SH3 domains 1 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Neighboring gene Sharpr-MPRA regulatory region 9303

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RELT induces cellular death in HEK 293 epithelial cells. Cusick JK, et al. Cell Immunol, 2010. PMID 19969290, Free PMC Article
  2. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. Cusick JK, et al. Biochem Biophys Res Commun, 2006 Feb 10. PMID 16389068
  3. Identification of PLSCR1 as a protein that interacts with RELT family members. Cusick JK, et al. Mol Cell Biochem, 2012 Mar. PMID 22052202
  4. RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1. Moua P, et al. Biochem Biophys Res Commun, 2017 Sep 9. PMID 28688764, Free PMC Article
  5. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. Shamay M, et al. J Virol, 2012 May. PMID 22379092, Free PMC Article

See all (15) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90583

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell-substrate adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
  
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RELT-like protein 2
Names
receptor expressed in lymphoid tissues like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130029.2 → NP_001123501.1  RELT-like protein 2

    See identical proteins and their annotated locations for NP_001123501.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK054889, AK075064, AY358163, BC027919, BC063469
    Consensus CDS
    CCDS4265.1
    UniProtKB/Swiss-Prot
    Q8NC24
    Related
    ENSP00000409443.1, ENST00000444782.5
    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; tumor necrosis factor receptor superfamily member 19

  2. NM_173828.5 → NP_776189.3  RELT-like protein 2

    See identical proteins and their annotated locations for NP_776189.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AK054889, AK075064, AY358163
    Consensus CDS
    CCDS4265.1
    UniProtKB/Swiss-Prot
    Q8NC24
    Related
    ENSP00000297164.3, ENST00000297164.8
    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; tumor necrosis factor receptor superfamily member 19

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    141636961..141641077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537625.3 → XP_011535927.1  RELT-like protein 2 isoform X2

    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; Tumour necrosis factor receptor superfamily member 19

  2. XM_011537624.2 → XP_011535926.1  RELT-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011535926.1

    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; Tumour necrosis factor receptor superfamily member 19

  3. XM_005268414.4 → XP_005268471.1  RELT-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005268471.1

    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; Tumour necrosis factor receptor superfamily member 19

  4. XM_024446029.1 → XP_024301797.1  RELT-like protein 2 isoform X3

    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; tumor necrosis factor receptor superfamily member 19
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NC24.1 GenPept UniProtKB/Swiss-Prot:Q8NC24

Gene LinkOut

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