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RELL2 RELT like 2 [ Homo sapiens (human) ]

Gene ID: 285613, updated on 9-Jun-2025
Official Symbol
RELL2provided by HGNC
Official Full Name
RELT like 2provided by HGNC
Primary source
HGNC:HGNC:26902
See related
Ensembl:ENSG00000164620 MIM:611213; AllianceGenome:HGNC:26902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5orf16
Summary
Predicted to enable collagen binding activity. Involved in positive regulation of p38MAPK cascade. Predicted to be located in basement membrane and plasma membrane. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in spleen (RPKM 5.1), lymph node (RPKM 4.7) and 24 other tissues See more
Orthologs
mouse all
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See RELL2 in Genome Data Viewer
Location:
5q31.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (141636997..141641064)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (142163003..142167070)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141016564..141020631)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene diaphanous related formin 1 Neighboring gene RPS27A pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23308 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:140998145-140998341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23309 Neighboring gene Sharpr-MPRA regulatory region 64 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23311 Neighboring gene histone deacetylase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141029007-141029585 Neighboring gene FCH and double SH3 domains 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:141037429-141038628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16459 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141053759-141054426 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141054427-141055095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141071853-141072386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141072387-141072920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141080718-141081218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23312 Neighboring gene uncharacterized LOC124901092 Neighboring gene uncharacterized LOC124901093

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Comprehensive Analysis of RELL2 as a Potential Biomarker Associated with Tumor Immune Infiltrating Cells in a Pan-Cancer Analysis. Musha K, et al. Dis Markers, 2022. PMID 35634441, Free PMC Article
  2. RELT induces cellular death in HEK 293 epithelial cells. Cusick JK, et al. Cell Immunol, 2010. PMID 19969290, Free PMC Article
  3. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. Cusick JK, et al. Biochem Biophys Res Commun, 2006 Feb 10. PMID 16389068
  4. Identification of PLSCR1 as a protein that interacts with RELT family members. Cusick JK, et al. Mol Cell Biochem, 2012 Mar. PMID 22052202
  5. RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1. Moua P, et al. Biochem Biophys Res Commun, 2017 Sep 9. PMID 28688764, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comprehensive Analysis of RELL2 as a Potential Biomarker Associated with Tumor Immune Infiltrating Cells in a Pan-Cancer Analysis.
    Title: Comprehensive Analysis of RELL2 as a Potential Biomarker Associated with Tumor Immune Infiltrating Cells in a Pan-Cancer Analysis.
  2. report that overexpression of RELT or its homologues RELL1 and RELL2 in HEK 293 epithelial cells results in cell death with morphological characteristics consistent with the activation of an apoptotic pathway.
    Title: RELT induces cellular death in HEK 293 epithelial cells.
  3. Binds to the TNF receptor family member RELT; homologue of RELT.
    Title: Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ90583

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell-substrate adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
RELT-like protein 2
Names
receptor expressed in lymphoid tissues like 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130029.2 → NP_001123501.1  RELT-like protein 2

    See identical proteins and their annotated locations for NP_001123501.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK054889, AK075064, AY358163, BC027919, BC063469
    Consensus CDS
    CCDS4265.1
    UniProtKB/Swiss-Prot
    D3DQE2, Q6P4E7, Q6UXY2, Q8NC24
    Related
    ENSP00000409443.1, ENST00000444782.5
    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; tumor necrosis factor receptor superfamily member 19

  2. NM_173828.5 → NP_776189.3  RELT-like protein 2

    See identical proteins and their annotated locations for NP_776189.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AK054889, AK075064, AY358163
    Consensus CDS
    CCDS4265.1
    UniProtKB/Swiss-Prot
    D3DQE2, Q6P4E7, Q6UXY2, Q8NC24
    Related
    ENSP00000297164.3, ENST00000297164.8
    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; tumor necrosis factor receptor superfamily member 19

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    141636997..141641064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537625.4 → XP_011535927.1  RELT-like protein 2 isoform X2

    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; Tumour necrosis factor receptor superfamily member 19

  2. XM_011537624.3 → XP_011535926.1  RELT-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011535926.1

    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; Tumour necrosis factor receptor superfamily member 19

  3. XM_005268414.5 → XP_005268471.1  RELT-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005268471.1

    Conserved Domains (1) summary
    pfam12606
    Location:28 → 60
    RELT; Tumour necrosis factor receptor superfamily member 19

  4. XM_047417113.1 → XP_047273069.1  RELT-like protein 2 isoform X3

    UniProtKB/Swiss-Prot
    D3DQE2, Q6P4E7, Q6UXY2, Q8NC24

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    142163003..142167070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352436.1 → XP_054208411.1  RELT-like protein 2 isoform X2

  2. XM_054352434.1 → XP_054208409.1  RELT-like protein 2 isoform X1

  3. XM_054352437.1 → XP_054208412.1  RELT-like protein 2 isoform X3

  4. XM_054352435.1 → XP_054208410.1  RELT-like protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NC24.1 GenPept UniProtKB/Swiss-Prot:Q8NC24

Gene LinkOut

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