Format

Send to:

Choose Destination

GPR33 G protein-coupled receptor 33 [ Homo sapiens (human) ]

Gene ID: 2856, updated on 11-Jun-2021

Summary

Official Symbol
GPR33provided by HGNC
Official Full Name
G protein-coupled receptor 33provided by HGNC
Primary source
HGNC:HGNC:4489
See related
Ensembl:ENSG00000214943 MIM:610118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GPR33 in Genome Data Viewer
Location:
14q12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (31482875..31488039, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31952081..31957245, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HEATR5A divergent transcript Neighboring gene uncharacterized LOC105370438 Neighboring gene D-aminoacyl-tRNA deacylase 2 Neighboring gene ribosomal protein L9 pseudogene 4 Neighboring gene NUBPL divergent transcript Neighboring gene nucleotide binding protein like Neighboring gene RNA, U6 small nuclear 602, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 33
Names
G protein-coupled receptor 33 pseudogene

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197184.3NP_001184113.2  probable G-protein coupled receptor 33

    See identical proteins and their annotated locations for NP_001184113.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the protein coding transcript, encoding Arg (CGA, aa 140) at the polymorphic site instead of the premature translation termination codon (TGA).
    Source sequence(s)
    AL163973, GQ981322, KF459682
    Consensus CDS
    CCDS73628.1
    UniProtKB/Swiss-Prot
    Q49SQ1
    UniProtKB/TrEMBL
    D8VER1
    Related
    ENSP00000421557.1, ENST00000399285.5
    Conserved Domains (1) summary
    pfam00001
    Location:47265
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. NR_036675.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) represents the predominant non-functional allele. It contains a translation termination codon (TGA) at the polymorphic site, resulting in a truncated open reading frame (ORF), compared to the full-length ORF in variant 1, coding.
    Source sequence(s)
    AL163973, GQ981321

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    31482875..31488039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_001132.2: Suppressed sequence

    Description
    NG_001132.2: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Support Center