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FAM200B family with sequence similarity 200 member B [ Homo sapiens (human) ]

Gene ID: 285550, updated on 5-Aug-2022

Summary

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Official Symbol
FAM200Bprovided by HGNC
Official Full Name
family with sequence similarity 200 member Bprovided by HGNC
Primary source
HGNC:HGNC:27740
See related
Ensembl:ENSG00000237765 AllianceGenome:HGNC:27740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf53
Expression
Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 5.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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See FAM200B in Genome Data Viewer
Location:
4p15.32
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (15636791..15690447)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (15663986..15672602)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15683450..15692070)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene uncharacterized LOC124900672 Neighboring gene uncharacterized LOC124900671 Neighboring gene F-box and leucine rich repeat protein 5 Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene prefoldin subunit 1 pseudogene Neighboring gene ribosomal protein L10a pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
  3. TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. Banks CA, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609421, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (8) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 200, member B (FAM200B; LOC285550) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
protein FAM200B
Names
Putative protein FAM200B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145191.2 → NP_001138663.1  protein FAM200B

    See identical proteins and their annotated locations for NP_001138663.1

    Status: VALIDATED

    Source sequence(s)
    AC114744, BC035074, BQ004196
    Consensus CDS
    CCDS47028.1
    UniProtKB/Swiss-Prot
    P0CF97
    Related
    ENSP00000393017.2, ENST00000422728.3
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    15636791..15690447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047450112.1 → XP_047306068.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  2. XM_047450110.1 → XP_047306066.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  3. XM_047450107.1 → XP_047306063.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  4. XM_047450106.1 → XP_047306062.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  5. XM_047450117.1 → XP_047306073.1  protein FAM200B isoform X2

  6. XM_024454005.2 → XP_024309773.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  7. XM_024454006.2 → XP_024309774.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  8. XM_024454011.2 → XP_024309779.1  protein FAM200B isoform X2

  9. XM_047450104.1 → XP_047306060.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  10. XM_024454010.2 → XP_024309778.1  protein FAM200B isoform X2

  11. XM_024454001.2 → XP_024309769.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  12. XM_024454003.2 → XP_024309771.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  13. XM_024454009.2 → XP_024309777.1  protein FAM200B isoform X2

  14. XM_047450103.1 → XP_047306059.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  15. XM_047450114.1 → XP_047306070.1  protein FAM200B isoform X2

  16. XM_047450108.1 → XP_047306064.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  17. XM_047450109.1 → XP_047306065.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  18. XM_047450113.1 → XP_047306069.1  protein FAM200B isoform X2

  19. XM_017008048.2 → XP_016863537.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  20. XM_047450115.1 → XP_047306071.1  protein FAM200B isoform X2

  21. XM_024453999.2 → XP_024309767.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  22. XM_024454000.2 → XP_024309768.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  23. XM_024454008.2 → XP_024309776.1  protein FAM200B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    15663986..15672602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CF97.1 GenPept UniProtKB/Swiss-Prot:P0CF97

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