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FAM200B family with sequence similarity 200 member B [ Homo sapiens (human) ]

Gene ID: 285550, updated on 9-Sep-2025
Official Symbol
FAM200Bprovided by HGNC
Official Full Name
family with sequence similarity 200 member Bprovided by HGNC
Primary source
HGNC:HGNC:27740
See related
Ensembl:ENSG00000237765 AllianceGenome:HGNC:27740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf53
Expression
Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 5.5) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See FAM200B in Genome Data Viewer
Location:
4p15.32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (15636791..15690447)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (15618958..15672602)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15683450..15692070)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene uncharacterized LOC124900672 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:15545311-15545892 Neighboring gene CC2D2A antisense RNA 1 Neighboring gene F-box and leucine rich repeat protein 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:15637196-15637392 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:15648787-15649012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15297 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:15656873-15657050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21343 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:15696758-15697354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15300 Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene ribosomal protein L10a pseudogene 7 Neighboring gene PFDN1 pseudogene 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Identification of SARS-CoV-2 PLpro and 3CLpro human proteome substrates using substrate phage display coupled with protein network analysis. Zhao K, et al. J Biol Chem, 2023 Jun. PMID 37201587, Free PMC Article
  2. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
  4. TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. Banks CA, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609421, Free PMC Article
  5. EndoMAP.v1 charts the structural landscape of human early endosome complexes. Gonzalez-Lozano MA, et al. Nature, 2025 Jul. PMID 40437099, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 200, member B (FAM200B; LOC285550) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
protein FAM200B
Names
Putative protein FAM200B

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145191.2 → NP_001138663.1  protein FAM200B

    See identical proteins and their annotated locations for NP_001138663.1

    Status: VALIDATED

    Source sequence(s)
    AC114744, BC035074, BQ004196
    Consensus CDS
    CCDS47028.1
    UniProtKB/Swiss-Prot
    P0CF97
    Related
    ENSP00000393017.2, ENST00000422728.3
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    15636791..15690447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047450112.1 → XP_047306068.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  2. XM_047450110.1 → XP_047306066.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  3. XM_047450107.1 → XP_047306063.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Related
    ENSP00000596205.1, ENST00000926146.1

  4. XM_047450106.1 → XP_047306062.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Related
    ENSP00000529567.1, ENST00000859508.1

  5. XM_047450117.1 → XP_047306073.1  protein FAM200B isoform X2

  6. XM_024454005.2 → XP_024309773.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  7. XM_024454006.2 → XP_024309774.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  8. XM_024454011.2 → XP_024309779.1  protein FAM200B isoform X2

  9. XM_047450104.1 → XP_047306060.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  10. XM_024454010.2 → XP_024309778.1  protein FAM200B isoform X2

  11. XM_024454001.2 → XP_024309769.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  12. XM_024454003.2 → XP_024309771.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  13. XM_024454009.2 → XP_024309777.1  protein FAM200B isoform X2

  14. XM_047450103.1 → XP_047306059.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  15. XM_047450114.1 → XP_047306070.1  protein FAM200B isoform X2

  16. XM_047450108.1 → XP_047306064.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  17. XM_047450109.1 → XP_047306065.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97

  18. XM_047450113.1 → XP_047306069.1  protein FAM200B isoform X2

  19. XM_017008048.2 → XP_016863537.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  20. XM_047450115.1 → XP_047306071.1  protein FAM200B isoform X2

  21. XM_024453999.2 → XP_024309767.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  22. XM_024454000.2 → XP_024309768.1  protein FAM200B isoform X1

    UniProtKB/Swiss-Prot
    P0CF97
    Conserved Domains (1) summary
    pfam14291
    Location:184 → 304
    DUF4371; Domain of unknown function (DUF4371)

  23. XM_024454008.2 → XP_024309776.1  protein FAM200B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    15618958..15672602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349774.1 → XP_054205749.1  protein FAM200B isoform X1

  2. XM_054349773.1 → XP_054205748.1  protein FAM200B isoform X1

  3. XM_054349763.1 → XP_054205738.1  protein FAM200B isoform X1

  4. XM_054349780.1 → XP_054205755.1  protein FAM200B isoform X2

  5. XM_054349771.1 → XP_054205746.1  protein FAM200B isoform X1

  6. XM_054349772.1 → XP_054205747.1  protein FAM200B isoform X1

  7. XM_054349779.1 → XP_054205754.1  protein FAM200B isoform X2

  8. XM_054349762.1 → XP_054205737.1  protein FAM200B isoform X1

  9. XM_054349781.1 → XP_054205756.1  protein FAM200B isoform X2

  10. XM_054349769.1 → XP_054205744.1  protein FAM200B isoform X1

  11. XM_054349770.1 → XP_054205745.1  protein FAM200B isoform X1

  12. XM_054349778.1 → XP_054205753.1  protein FAM200B isoform X2

  13. XM_054349766.1 → XP_054205741.1  protein FAM200B isoform X1

  14. XM_054349765.1 → XP_054205740.1  protein FAM200B isoform X1

  15. XM_054349784.1 → XP_054205759.1  protein FAM200B isoform X2

  16. XM_054349775.1 → XP_054205750.1  protein FAM200B isoform X1

  17. XM_054349776.1 → XP_054205751.1  protein FAM200B isoform X1

  18. XM_054349783.1 → XP_054205758.1  protein FAM200B isoform X2

  19. XM_054349764.1 → XP_054205739.1  protein FAM200B isoform X1

  20. XM_054349782.1 → XP_054205757.1  protein FAM200B isoform X2

  21. XM_054349767.1 → XP_054205742.1  protein FAM200B isoform X1

  22. XM_054349768.1 → XP_054205743.1  protein FAM200B isoform X1

  23. XM_054349777.1 → XP_054205752.1  protein FAM200B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CF97.1 GenPept UniProtKB/Swiss-Prot:P0CF97

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