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RNF175 ring finger protein 175 [ Homo sapiens (human) ]

Gene ID: 285533, updated on 22-Sep-2022

Summary

Official Symbol
RNF175provided by HGNC
Official Full Name
ring finger protein 175provided by HGNC
Primary source
HGNC:HGNC:27735
See related
Ensembl:ENSG00000145428 AllianceGenome:HGNC:27735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in appendix (RPKM 5.6), brain (RPKM 2.9) and 18 other tissues See more
Orthologs
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Genomic context

See RNF175 in Genome Data Viewer
Location:
4q31.3
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153710160..153760024, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (157034616..157084499, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154631312..154681176, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane 131 like Neighboring gene uncharacterized LOC105377498 Neighboring gene toll like receptor 2 pseudogene Neighboring gene WD repeat domain 45 pseudogene 1 Neighboring gene uncharacterized LOC105377499 Neighboring gene toll like receptor 2 Neighboring gene Sharpr-MPRA regulatory region 15425 Neighboring gene Sharpr-MPRA regulatory region 5783 Neighboring gene secreted frizzled related protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34190

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016386.2 RefSeqGene

    Range
    5000..54864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173662.4NP_775933.2  RING finger protein 175

    Status: VALIDATED

    Source sequence(s)
    AC020703, AC106865
    Consensus CDS
    CCDS47149.1
    UniProtKB/Swiss-Prot
    Q8NB61
    Related
    ENSP00000340979.4, ENST00000347063.9
    Conserved Domains (1) summary
    cd16475
    Location:225279
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    153710160..153760024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008047.2XP_016863536.1  RING finger protein 175 isoform X7

  2. XM_005262939.4XP_005262996.1  RING finger protein 175 isoform X5

    See identical proteins and their annotated locations for XP_005262996.1

    Conserved Domains (1) summary
    pfam13639
    Location:145197
    zf-RING_2; Ring finger domain
  3. XM_005262938.4XP_005262995.1  RING finger protein 175 isoform X2

    Conserved Domains (1) summary
    COG4776
    Location:217287
    Rnb; Exoribonuclease II [Transcription]
  4. XM_011531879.3XP_011530181.1  RING finger protein 175 isoform X1

    Conserved Domains (1) summary
    pfam13639
    Location:193245
    zf-RING_2; Ring finger domain
  5. XM_047450102.1XP_047306058.1  RING finger protein 175 isoform X3

  6. XM_005262940.5XP_005262997.1  RING finger protein 175 isoform X6

    Conserved Domains (1) summary
    pfam13639
    Location:144196
    zf-RING_2; Ring finger domain
  7. XM_011531882.3XP_011530184.1  RING finger protein 175 isoform X4

    Conserved Domains (1) summary
    cl17238
    Location:225255
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    157034616..157084499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)