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TPRG1 tumor protein p63 regulated 1 [ Homo sapiens (human) ]

Gene ID: 285386, updated on 25-Jan-2022

Summary

Official Symbol
TPRG1provided by HGNC
Official Full Name
tumor protein p63 regulated 1provided by HGNC
Primary source
HGNC:HGNC:24759
See related
Ensembl:ENSG00000188001 AllianceGenome:HGNC:24759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM79B
Summary
Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in esophagus (RPKM 2.6), skin (RPKM 1.9) and 7 other tissues See more
Orthologs
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Genomic context

See TPRG1 in Genome Data Viewer
Location:
3q28
Exon count:
26
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (189000779..189325304)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (188889760..189043093)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986168 Neighboring gene Sharpr-MPRA regulatory region 8956 Neighboring gene uncharacterized LOC107986167 Neighboring gene enolase-phosphatase 1 pseudogene Neighboring gene TPRG1 antisense RNA 2 Neighboring gene uncharacterized LOC105374270 Neighboring gene uncharacterized LOC107986169

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41238, FLJ43694, MGC126599, MGC126601

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tumor protein p63-regulated gene 1 protein
Names
family with sequence similarity 79, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198485.4NP_940887.1  tumor protein p63-regulated gene 1 protein

    See identical proteins and their annotated locations for NP_940887.1

    Status: VALIDATED

    Source sequence(s)
    AC104669, AC112909, AK125682, BC101550, CR737485
    Consensus CDS
    CCDS3292.1
    UniProtKB/Swiss-Prot
    Q6ZUI0
    Related
    ENSP00000341031.3, ENST00000345063.8
    Conserved Domains (1) summary
    pfam12456
    Location:70170
    hSac2; Inositol phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    189000779..189325304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006261.2XP_016861750.1  tumor protein p63-regulated gene 1 protein isoform X3

    UniProtKB/Swiss-Prot
    Q6ZUI0
    Related
    ENSP00000412547.1, ENST00000433971.5
    Conserved Domains (1) summary
    pfam12456
    Location:70170
    hSac2; Inositol phosphatase
  2. XM_024453479.1XP_024309247.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  3. XM_024453478.1XP_024309246.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  4. XM_017006257.1XP_016861746.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  5. XM_024453473.1XP_024309241.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  6. XM_024453477.1XP_024309245.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  7. XM_024453475.1XP_024309243.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  8. XM_024453480.1XP_024309248.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  9. XM_024453474.1XP_024309242.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  10. XM_024453476.1XP_024309244.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  11. XM_024453481.1XP_024309249.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  12. XM_024453482.1XP_024309250.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  13. XM_017006258.1XP_016861747.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  14. XM_024453483.1XP_024309251.1  tumor protein p63-regulated gene 1 protein isoform X3

    Conserved Domains (1) summary
    pfam12456
    Location:70170
    hSac2; Inositol phosphatase
  15. XM_017006260.1XP_016861749.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  16. XM_017006259.1XP_016861748.1  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  17. XM_011512732.2XP_011511034.2  tumor protein p63-regulated gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam12456
    Location:70190
    hSac2; Inositol phosphatase
  18. XM_005247382.5XP_005247439.1  tumor protein p63-regulated gene 1 protein isoform X2

    Conserved Domains (1) summary
    pfam12456
    Location:78178
    hSac2; Inositol phosphatase
  19. XM_011512735.3XP_011511037.1  tumor protein p63-regulated gene 1 protein isoform X5

    Conserved Domains (1) summary
    pfam12456
    Location:78108
    hSac2; Inositol phosphatase
  20. XM_011512734.3XP_011511036.1  tumor protein p63-regulated gene 1 protein isoform X4

    Conserved Domains (1) summary
    pfam12456
    Location:78178
    hSac2; Inositol phosphatase
  21. XM_005247388.4XP_005247445.1  tumor protein p63-regulated gene 1 protein isoform X8

    Conserved Domains (1) summary
    pfam12456
    Location:78109
    hSac2; Inositol phosphatase
  22. XM_011512736.3XP_011511038.1  tumor protein p63-regulated gene 1 protein isoform X7

    Conserved Domains (1) summary
    pfam12456
    Location:78109
    hSac2; Inositol phosphatase
  23. XM_017006262.1XP_016861751.1  tumor protein p63-regulated gene 1 protein isoform X6

  24. XM_017006263.1XP_016861752.1  tumor protein p63-regulated gene 1 protein isoform X6

RNA

  1. XR_001740120.2 RNA Sequence

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