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PRRT3 proline rich transmembrane protein 3 [ Homo sapiens (human) ]

Gene ID: 285368, updated on 11-Jun-2021

Summary

Official Symbol
PRRT3provided by HGNC
Official Full Name
proline rich transmembrane protein 3provided by HGNC
Primary source
HGNC:HGNC:26591
See related
Ensembl:ENSG00000163704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 3.4), prostate (RPKM 1.2) and 21 other tissues See more
Orthologs
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Genomic context

See PRRT3 in Genome Data Viewer
Location:
3p25.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9945542..9952408, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9987226..9994092, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 882, pseudogene Neighboring gene interleukin 17 receptor C Neighboring gene cysteine rich with EGF like domains 1 Neighboring gene 3p25 PRRT3 Alu-mediated recombination region Neighboring gene PRRT3 antisense RNA 1 Neighboring gene ER membrane protein complex subunit 3 Neighboring gene EMC3 antisense RNA 1 Neighboring gene FANCD2 pseudogene 1 Neighboring gene CYCS pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PRRT3 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33674, MGC33990, MGC105134

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proline-rich transmembrane protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318871.2NP_001305800.1  proline-rich transmembrane protein 3 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, lacks a portion of the 3' coding region and its 3' terminal exon extends past a known splice site, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC018809, AY358158, BM544786
    Consensus CDS
    CCDS82732.1
    UniProtKB/Swiss-Prot
    Q5FWE3
    Related
    ENSP00000404512.2, ENST00000411976.2
    Conserved Domains (1) summary
    PHA03247
    Location:31392
    PHA03247; large tegument protein UL36; Provisional
  2. NM_207351.5NP_997234.3  proline-rich transmembrane protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_997234.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC018809, AK090993, BC040508, BC089447, BM544786
    Consensus CDS
    CCDS43049.1
    UniProtKB/Swiss-Prot
    Q5FWE3
    Related
    ENSP00000392511.1, ENST00000412055.6
    Conserved Domains (1) summary
    PHA03247
    Location:84468
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. NR_134900.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC018809, BC089447, BM544786

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    9945542..9952408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533628.2XP_011531930.1  proline-rich transmembrane protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011531930.1

    UniProtKB/Swiss-Prot
    Q5FWE3
    Conserved Domains (1) summary
    PHA03247
    Location:84468
    PHA03247; large tegument protein UL36; Provisional
  2. XM_011533629.2XP_011531931.1  proline-rich transmembrane protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011531931.1

    UniProtKB/Swiss-Prot
    Q5FWE3
    Conserved Domains (1) summary
    PHA03247
    Location:84468
    PHA03247; large tegument protein UL36; Provisional
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