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ZNF852 zinc finger protein 852 [ Homo sapiens (human) ]

Gene ID: 285346, updated on 3-May-2025
Official Symbol
ZNF852provided by HGNC
Official Full Name
zinc finger protein 852provided by HGNC
Primary source
HGNC:HGNC:27713
See related
Ensembl:ENSG00000178917 AllianceGenome:HGNC:27713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, May 2025]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in prostate (RPKM 1.1), spleen (RPKM 1.0) and 25 other tissues See more
Orthologs
all
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See ZNF852 in Genome Data Viewer
Location:
3p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44491766..44510617, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44507580..44526413, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44533258..44552109, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 694 Neighboring gene zinc finger protein 445 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:44482886-44483092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14264 Neighboring gene uncharacterized LOC101928529 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44551492-44552268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44552269-44553045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19766 Neighboring gene zinc finger protein 852 pseudogene Neighboring gene EI24 pseudogene 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self-renewal of gastric cancer cells. Ke C, et al. Cell Biol Int, 2022 Apr. PMID 34957631
  2. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
  3. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self-renewal of gastric cancer cells.
    Title: Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self-renewal of gastric cancer cells.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 852
Names
putative zinc finger protein 852

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287349.3 → NP_001274278.1  zinc finger protein 852 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the same splice pattern as variant 1, but represents an alternate allele. This transcript lacks two nucleotides compared to GRCh38 to represent the variation reported by the rs36046723 SNP. The encoded isoform (3) has a frameshifted C-terminus, compared to isoform 1.
    Source sequence(s)
    AC099669, AK296954
    UniProtKB/Swiss-Prot
    Q6ZMS4

  2. NM_001423469.1 → NP_001410398.1  zinc finger protein 852 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the allele encoded by the reference genome (GRCh38) and encodes isoform 1.
    Source sequence(s)
    AC099669
    UniProtKB/Swiss-Prot
    B4DLD7, Q6ZMS4
    Related
    ENSP00000389841.2, ENST00000436261.7

  3. NM_001423470.1 → NP_001410399.1  zinc finger protein 852 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the allele encoded by the reference genome (GRCh38) and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is one amino acid longer than isoform 1.
    Source sequence(s)
    AC099669
    Related
    ENSP00000520482.1, ENST00000715584.1

  4. NM_001423484.1 → NP_001410413.1  zinc finger protein 852 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the same splice pattern as variant 2, but represents an alternate allele. This transcript lacks two nucleotides compared to GRCh38 to represent the variation reported by the rs36046723 SNP. The encoded isoform (4) has a frameshifted C-terminus, compared to isoform 2.
    Source sequence(s)
    AC099669, AK296954
    UniProtKB/TrEMBL
    A0AAQ5BIJ6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44491766..44510617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    17120..35971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44507580..44526413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZMS4.4 GenPept UniProtKB/Swiss-Prot:Q6ZMS4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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