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ZNF852 zinc finger protein 852 [ Homo sapiens (human) ]

Gene ID: 285346, updated on 5-Mar-2024

Summary

Official Symbol
ZNF852provided by HGNC
Official Full Name
zinc finger protein 852provided by HGNC
Primary source
HGNC:HGNC:27713
See related
Ensembl:ENSG00000178917 AllianceGenome:HGNC:27713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in prostate (RPKM 1.1), spleen (RPKM 1.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF852 in Genome Data Viewer
Location:
3p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44491766..44510617, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44507580..44526413, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44533258..44552109, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 694 Neighboring gene zinc finger protein 445 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:44482886-44483092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14264 Neighboring gene uncharacterized LOC101928529 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44551492-44552268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44552269-44553045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19766 Neighboring gene zinc finger protein 852 pseudogene Neighboring gene EI24 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger protein 852
Names
putative zinc finger protein 852

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287349.3NP_001274278.1  zinc finger protein 852 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the same splice pattern as variant 1, but represents an alternate allele. This transcript lacks two nucleotides compared to GRCh38 to represent the variation reported by the rs36046723 SNP. The encoded isoform (3) has a frameshifted C-terminus, compared to isoform 1.
    Source sequence(s)
    AC099669, AK296954
    UniProtKB/Swiss-Prot
    Q6ZMS4
  2. NM_001423469.1NP_001410398.1  zinc finger protein 852 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the allele encoded by the reference genome (GRCh38) and encodes isoform 1.
    Source sequence(s)
    AC099669
    UniProtKB/Swiss-Prot
    B4DLD7, Q6ZMS4
    Related
    ENSP00000389841.2, ENST00000436261.6
  3. NM_001423470.1NP_001410399.1  zinc finger protein 852 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the allele encoded by the reference genome (GRCh38) and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is one amino acid longer than isoform 1.
    Source sequence(s)
    AC099669
  4. NM_001423484.1NP_001410413.1  zinc finger protein 852 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the same splice pattern as variant 2, but represents an alternate allele. This transcript lacks two nucleotides compared to GRCh38 to represent the variation reported by the rs36046723 SNP. The encoded isoform (4) has a frameshifted C-terminus, compared to isoform 2.
    Source sequence(s)
    AC099669, AK296954

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44491766..44510617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    17120..35971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44507580..44526413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)