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C3orf33 chromosome 3 open reading frame 33 [ Homo sapiens (human) ]

Gene ID: 285315, updated on 22-Sep-2022

Summary

Official Symbol
C3orf33provided by HGNC
Official Full Name
chromosome 3 open reading frame 33provided by HGNC
Primary source
HGNC:HGNC:26434
See related
Ensembl:ENSG00000174928 MIM:619654; AllianceGenome:HGNC:26434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AC3-33
Summary
Involved in negative regulation of ERK1 and ERK2 cascade and regulation of DNA-binding transcription factor activity. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.9), adrenal (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See C3orf33 in Genome Data Viewer
Location:
3q25.31
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (155762617..155806278, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (158536490..158580161, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (155480406..155524067, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phospholipase C eta 1 Neighboring gene ribosomal protein L6 pseudogene 7 Neighboring gene ribosomal protein L7a pseudogene 24 Neighboring gene solute carrier family 33 member 1 Neighboring gene uncharacterized LOC105374174

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein C3orf33
Names
AP-1 activity suppressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308229.2NP_001295158.1  protein C3orf33 isoform 1

    See identical proteins and their annotated locations for NP_001295158.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC104472, AF115515, DA275323
    Consensus CDS
    CCDS77843.1
    UniProtKB/Swiss-Prot
    Q6P1S2, Q96NB5
    Related
    ENSP00000342512.2, ENST00000340171.7
  2. NM_173657.3NP_775928.1  protein C3orf33 isoform 2

    See identical proteins and their annotated locations for NP_775928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC104472, AK055701, DA275323
    Consensus CDS
    CCDS54659.1
    UniProtKB/Swiss-Prot
    Q6P1S2
    Related
    ENSP00000445446.1, ENST00000534941.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    155762617..155806278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512710.3XP_011511012.1  protein C3orf33 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    158536490..158580161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)