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IGSF10 immunoglobulin superfamily member 10 [ Homo sapiens (human) ]

Gene ID: 285313, updated on 8-Jul-2021

Summary

Official Symbol
IGSF10provided by HGNC
Official Full Name
immunoglobulin superfamily member 10provided by HGNC
Primary source
HGNC:HGNC:26384
See related
Ensembl:ENSG00000152580 MIM:617351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMF608
Expression
Broad expression in gall bladder (RPKM 9.0), ovary (RPKM 8.9) and 19 other tissues See more
Orthologs
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Genomic context

See IGSF10 in Genome Data Viewer
Location:
3q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (151435051..151619926, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151153991..151257104, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene purinergic receptor P2Y13 Neighboring gene purinergic receptor P2Y12 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 6 Neighboring gene microRNA 5186 Neighboring gene uncharacterized LOC105374157 Neighboring gene long intergenic non-protein coding RNA 2066

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25972

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
immunoglobulin superfamily member 10
Names
calvaria mechanical force protein 608

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178145.3NP_001171616.2  immunoglobulin superfamily member 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC024886
    Related
    ENST00000495443.1
    Conserved Domains (3) summary
    pfam13927
    Location:410489
    Ig_3; Immunoglobulin domain
    cd00096
    Location:420424
    Ig; putative Ig strand A' [structural motif]
    cl11960
    Location:120203
    Ig; Immunoglobulin domain
  2. NM_001178146.3NP_001171617.1  immunoglobulin superfamily member 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC024886
    UniProtKB/Swiss-Prot
    Q6WRI0
    Related
    ENST00000493841.1
    Conserved Domains (3) summary
    pfam13927
    Location:410489
    Ig_3; Immunoglobulin domain
    cd00096
    Location:420424
    Ig; putative Ig strand A' [structural motif]
    cl11960
    Location:120203
    Ig; Immunoglobulin domain
  3. NM_001385060.1NP_001371989.1  immunoglobulin superfamily member 10 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC024886, AC117454
    Conserved Domains (10) summary
    TIGR00864
    Location:192317
    PCC; polycystin cation channel protein
    smart00013
    Location:2860
    LRRNT; Leucine rich repeat N-terminal domain
    smart00409
    Location:582662
    IG; Immunoglobulin
    sd00033
    Location:3958
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:12931667
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:81141
    LRR_8; Leucine rich repeat
    pfam13927
    Location:24312510
    Ig_3; Immunoglobulin domain
    cd00096
    Location:24412445
    Ig; putative Ig strand A' [structural motif]
    cd21340
    Location:76220
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl11960
    Location:17441837
    Ig; Immunoglobulin domain
  4. NM_001385061.1NP_001371990.1  immunoglobulin superfamily member 10 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC024886, AC117454
    Conserved Domains (10) summary
    TIGR00864
    Location:192317
    PCC; polycystin cation channel protein
    smart00013
    Location:2860
    LRRNT; Leucine rich repeat N-terminal domain
    smart00409
    Location:582662
    IG; Immunoglobulin
    sd00033
    Location:3958
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:12931667
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:81141
    LRR_8; Leucine rich repeat
    pfam13927
    Location:24312510
    Ig_3; Immunoglobulin domain
    cd00096
    Location:24412445
    Ig; putative Ig strand A' [structural motif]
    cd21340
    Location:76220
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl11960
    Location:17441837
    Ig; Immunoglobulin domain
  5. NM_001385062.1NP_001371991.1  immunoglobulin superfamily member 10 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC024886, AC117454
    Conserved Domains (10) summary
    TIGR00864
    Location:192317
    PCC; polycystin cation channel protein
    smart00013
    Location:2860
    LRRNT; Leucine rich repeat N-terminal domain
    smart00409
    Location:582662
    IG; Immunoglobulin
    sd00033
    Location:3958
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:12931667
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:81141
    LRR_8; Leucine rich repeat
    pfam13927
    Location:24312510
    Ig_3; Immunoglobulin domain
    cd00096
    Location:24412445
    Ig; putative Ig strand A' [structural motif]
    cd21340
    Location:76220
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl11960
    Location:17441837
    Ig; Immunoglobulin domain
  6. NM_001385063.1NP_001371992.1  immunoglobulin superfamily member 10 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC024886, AC117454
    Conserved Domains (10) summary
    TIGR00864
    Location:192317
    PCC; polycystin cation channel protein
    smart00013
    Location:2860
    LRRNT; Leucine rich repeat N-terminal domain
    smart00409
    Location:582662
    IG; Immunoglobulin
    sd00033
    Location:3958
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:12931667
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:81141
    LRR_8; Leucine rich repeat
    pfam13927
    Location:24312510
    Ig_3; Immunoglobulin domain
    cd00096
    Location:24412445
    Ig; putative Ig strand A' [structural motif]
    cd21340
    Location:76220
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl11960
    Location:17441837
    Ig; Immunoglobulin domain
  7. NM_178822.5NP_849144.2  immunoglobulin superfamily member 10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_849144.2

    Status: VALIDATED

    Source sequence(s)
    AC024886
    Consensus CDS
    CCDS3160.1
    UniProtKB/Swiss-Prot
    Q6WRI0
    Related
    ENSP00000282466.3, ENST00000282466.4
    Conserved Domains (10) summary
    TIGR00864
    Location:192317
    PCC; polycystin cation channel protein
    smart00013
    Location:2860
    LRRNT; Leucine rich repeat N-terminal domain
    smart00409
    Location:582662
    IG; Immunoglobulin
    sd00033
    Location:3958
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:12931667
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:81141
    LRR_8; Leucine rich repeat
    pfam13927
    Location:24312510
    Ig_3; Immunoglobulin domain
    cd00096
    Location:24412445
    Ig; putative Ig strand A' [structural motif]
    cd21340
    Location:76220
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl11960
    Location:17441837
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    151435051..151619926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512709.2XP_011511011.1  immunoglobulin superfamily member 10 isoform X2

    See identical proteins and their annotated locations for XP_011511011.1

    UniProtKB/Swiss-Prot
    Q6WRI0
    Conserved Domains (10) summary
    TIGR00864
    Location:192317
    PCC; polycystin cation channel protein
    smart00013
    Location:2860
    LRRNT; Leucine rich repeat N-terminal domain
    smart00409
    Location:582662
    IG; Immunoglobulin
    sd00033
    Location:3958
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05109
    Location:12931667
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13855
    Location:81141
    LRR_8; Leucine rich repeat
    pfam13927
    Location:24312510
    Ig_3; Immunoglobulin domain
    cd00096
    Location:24412445
    Ig; putative Ig strand A' [structural motif]
    cd21340
    Location:76220
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl11960
    Location:17441837
    Ig; Immunoglobulin domain
  2. XM_011512708.2XP_011511010.1  immunoglobulin superfamily member 10 isoform X1

    Conserved Domains (8) summary
    smart00408
    Location:22282292
    IGc2; Immunoglobulin C-2 Type
    smart00082
    Location:291309
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:24172500
    IG; Immunoglobulin
    smart00410
    Location:654734
    IG_like; Immunoglobulin like
    pfam07679
    Location:22132296
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:111130
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:153213
    LRR_8; Leucine rich repeat
    cl11960
    Location:17401812
    Ig; Immunoglobulin domain
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